Abstract：
:Granuloma modulation induced by antigen is an attractive model for vaccination studies of experimental schistosomiasis to test the effect of anti-pathology vaccine. We describe here an immunization procedure with culture derived macrophages-pulsed PIII, a known anionic antigen purified from S. mansoni adult worm, involved in the inhibition of granulomatous response to eggs. For our studies, peritoneal or spleen macrophages cultured over 15 days were loaded with PIII. Both macrophage sub-populations were capable to efficiently take up and subsequently present PIII to lymphocytes as evidenced by immunofluorescence assay. The vaccination of mice with intravenous injection of PIII-loaded macrophages potently induced antigen-specific immune response to S. mansoni antigens as determined by cell proliferation assay. This immunization procedure of mice caused significant decrease in hepatic granuloma formation and in vitro granuloma reaction to S. mansoni antigens coupled to polyacrylamide beads (PB-SEA, PB-SWAP or PB-PIII). Assessment of in vitro granuloma supernatant of spleen cells from PIII-loaded macrophages vaccinated mice revealed significant amounts of Th1-cytokines IFN-gamma and IL-2 compared to control cells. Collectively, our results indicate that culture derived-macrophages provided a valuable research tool to investigate aspects of immune response that promote modulation of granulomatous hypersensitivity to S. mansoni eggs in mice.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Gustavson S,Zouain CS,Alves JB,Leite MF,Goes AMdoi
10.1016/s1383-5769(02)00031-4subject
Has Abstractpub_date
2002-09-01 00:00:00pages
259-69issue
3eissn
1383-5769issn
1873-0329pii
S1383576902000314journal_volume
51pub_type
杂志文章abstract：:Hemoplasmosis caused by Mycoplasma spp. have been associated with major economic losses in the global dairy production. Hemoplasma studies in the Philippines are limited despite its potential impact. This study mainly aimed to detect the presence of hemoplasma species in dairy water buffaloes and cattle and know their...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.02.004
更新日期：2019-06-01 00:00:00
abstract：:The phospholipid metabolism of Plasmodium falciparum-infected erythrocytes has been shown to be an effective pharmacological target for novel chemotherapy. Thirty-seven monoquaternary ammonium derivatives analogous to choline were screened for their potential antiprotozoal activity against P. falciparum and Leishmania...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.09.006
更新日期：2008-06-01 00:00:00
abstract：:Brazilian sardine is emerging as a promising species in Aquaculture. This study describes for the first time a case of parasitic infestation by Amyloodinium in Brazilian sardines Sardinella brasiliensis obtained from natural spawning in captivity. The sardines kept in nurseries were naturally parasitized by the amylod...
journal_title：Parasitology international
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doi：10.1016/j.parint.2020.102091
更新日期：2020-06-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.08.006
更新日期：2015-02-01 00:00:00
abstract：:Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multipl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.002
更新日期：2009-12-01 00:00:00
abstract：:Septin4 (Sept4) belongs to Septin family and may be involved in apoptosis, vesicle trafficking and other cell processes. In this study, we attempted to investigate the effect of Sept4 in hepatic fibrosis induced by Schistosoma japonicum. ICR mice infected with S. japonicum for 12weeks were treated with PBS, Ad-ctr and...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.07.002
更新日期：2015-12-01 00:00:00
abstract：:The outcome of Plasmodium yoelii 17XL (P.y17XL)-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, depends largely on the establishment of effective Th1 and Th2 responses and a successful switch between Th1 and Th2 responses, as well as appropriate functioning of CD4(+)CD25(+)Foxp3(+)regulatory T ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.05.005
更新日期：2010-09-01 00:00:00
abstract：:Due to the increasing development of anthelmintic resistance in nematodes worldwide, it is important to search for anthelmintic compounds with new modes of action and also to investigate the possibility to combine compounds with possible synergistic effects. There might also be the chance to take advantage of the fact...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.05.006
更新日期：2013-12-01 00:00:00
abstract：:Haintestinum amplum n. g., n. sp. is described from the scrawled cowfish, Acanthostracion quadricornis, collected in the Eastern Gulf of Mexico off Florida, USA. The new species is relatively large and shares characters of the Apocreadiidae and Megaperidae but conforms to the diagnosis of neither. It belongs in a new ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.11.007
更新日期：2014-04-01 00:00:00
abstract：:Toxoplasma gondii and Neospora caninum are two closely related protozoan parasites which can cause abortion and significant economic losses in sheep and goats. However, it is yet to know whether black-bone sheep and goats are infected with T. gondii and N. caninum in China. In the present investigation, the seropreval...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.102041
更新日期：2020-04-01 00:00:00
abstract：:Chromosome analyses were performed on three races (alpha, beta, gamma) of Neotricula aperta which were previously reported to show variation in the chromosome number and pairing in meiosis. We used an air-drying method, which was more reliable for chromosome preparations from fresh animal tissues than a squash method....
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00053-2
更新日期：2000-12-01 00:00:00
abstract：:Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternative...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.06.005
更新日期：2015-10-01 00:00:00
abstract：:Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K272R, Y268C...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.09.011
更新日期：2015-06-01 00:00:00
abstract：:The clinical features of neurocysticercosis (NCC) largely depend on the number, type, size, localization and stage of development of cysticerci, as well as on the host immune response against the parasite. Seizures are widely reported to be the most common symptom, occurring in 70-90% of patients, while NCC is conside...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.016
更新日期：2006-01-01 00:00:00
abstract：:Neosporosis caused by Neospora caninum is a serious disease in cattle and dogs worldwide. It is the major cause of abortion and neonatal mortality in cattle. In this study, we evaluated the anti-N. caninum activity of Chinese medicine extracts (curcumin, artemether), herbicides (atrazine, glyphosate), anticoccidiosis ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.08.002
更新日期：2015-12-01 00:00:00
abstract：:This study was conducted both to assess the prevalence of parasitic infections in two neighboring villages of Manisa province in Turkey, with different socioeconomic levels and investigate the influences of some individual and environmental factors on these infections. A total of 100 school children were enrolled and ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.01.005
更新日期：2007-06-01 00:00:00
abstract：:Brasicystis bennetti Thatcher, 1979 was first described from specimens obtained from the subcutaneous tissues of the mouth and operculum of Plagioscyion squamosissimus from the Amazon River in Brazil, however since 2008, Brasicystis has been considered a genus inquirendum. This study reviews some of the diagnostic cha...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.01.001
更新日期：2013-04-01 00:00:00
abstract：:A survey was carried out to investigate the occurrence of Sarcocystis infection in the loin (Musculus longissimus) of Japanese and imported beef. In all, the muscle tissue of 482 samples were examined by histological method. The prevalence of Sarcocystis unspecified species cysts was lower in Japanese beef (total 6.31...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(98)00041-5
更新日期：1999-03-01 00:00:00
abstract：:Three different monoclonal antibodies were produced against Trypanosona cruzi proteasomes. These antibodies were shown to react with a single 27-kDa band on immunoblots of purified proteasomes. Using a 7E5 monoclonal antibody (IgG1) that recognized the alpha5 subunit of protozoan protease we have studied the intracell...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.012
更新日期：2009-12-01 00:00:00
abstract：:Giardia duodenalis represents one of the most widespread human enteric parasites: about 200million people in Asia, Africa and Latin America are infected. Giardia exerts a deep impact on public health because of high prevalence and possible effects on growth and cognitive functions in infected children. The major aim o...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.11.004
更新日期：2014-04-01 00:00:00
abstract：:Schistosomiasis is one of the most prevalent and serious parasitic diseases in the world and remains an important public health problem in China. Screening and discovery of an effective vaccine candidate or new drug target is crucial for the control of this disease. In this study, we cloned a cDNA encoding Schistosoma...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.03.005
更新日期：2012-09-01 00:00:00
abstract：:Except for imported cases, we have had no new Schistosoma japonicum infection in Japan since 1977. But there are still two habitats of the intermediate snail host: Oncomelania nosophora in the previous endemic areas of Kofu Basin and Obitsu. O. nosophora from Kofu Basin and Obitsu are susceptible to Chinese and Philip...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/s1383-5769(03)00058-8
更新日期：2003-12-01 00:00:00
abstract：:The pathogen Borrelia burgdorferi causes Lyme Borreliosis in human and animals world-wide. In Europe the pathogen is transmitted to the host by the vector Ixodes ricinus. The nymph is the primary instar for transmission to humans. We here study the infection rate of five Borrelia genospecies: B. burgdorferi sensu stri...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.07.004
更新日期：2008-03-01 00:00:00
abstract：:We report here the molecular characterization and possible function of a cysteine protease (termed HlCPL-A) identified in the midgut of the hard tick Haemaphysalis longicornis. HlCPL-A is a 333 amino acid protein belonging to the papain family of the cysteine protease. A construct encoding proHlCPL-A was expressed in ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.05.003
更新日期：2009-09-01 00:00:00
abstract：:Cysticercosis caused by infection with embryonated eggs of the pork tapeworm Taenia solium is an important cause of neurological disease worldwide. Based on the phylogenetic analysis of mitochondrial DNA, the pathogen has been divided into two geographic clades, corresponding to Afro-American and Asian genotypes. In t...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.11.004
更新日期：2011-01-01 00:00:00
abstract：:Immunodeficient mice were studied to determine their suitability as models in investigating the role of Taenia taeniaeformis larval products in the development of gastric hyperplasia. Recombinant active gene 2 (RAG2)-deficient and severe combined immune-deficient (SCID) mice were studied as candidate animal models. RA...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(01)00108-8
更新日期：2002-03-01 00:00:00
abstract：:To evaluate the geographic distribution of Giardia intestinalis genotypes in Nablus, West Bank, Palestine, a genotyping study was performed using clinical fecal samples. Microscopic examination confirmed that 8 of 69 (11.6%) samples were G. intestinalis positive, and subsequent genotyping analyses targeting the small-...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.04.002
更新日期：2009-09-01 00:00:00
abstract：:In murine leishmaniasis, the induction of the T-helper type 1 (Th1) response contributes to infection resistance, whereas the establishment of the Th2 response makes the mice susceptible to infection. Interleukin-12 (IL-12) plays a pivotal role in the diversification of immune responses to the Th1 type. In this study,...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(01)00070-8
更新日期：2001-07-01 00:00:00
abstract：:To assess the epidemiological efficacy of type SRP III slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and livestock, praziquantel-medicated bars were implanted subcutaneously in over 90% of dogs in villages in north Xinjiang, China, where cystic echinoc...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2005.06.002
更新日期：2005-12-01 00:00:00
abstract：:Moniezia expansa and M. benedeni are two common tapeworm species of domestic ruminants over the world. However, their morphological and molecular data are available for limited specimens from a few countries. In the present study, we compared morphological characteristics of these two species collected from goats and ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.101998
更新日期：2020-02-01 00:00:00
