Abstract：
:Eosinophilic meningitis caused by Angiostrongylus cantonensis is a zoonosis endemic to Southeast Asia and the Pacific islands. It is considered an emerging disease because it has been expanding both geographically and in terms of the range of hosts. In South America, the first cases were reported in Brazil and were attributed to eating infected snails. In this study, 70 adult females of Rattus norvegicus (Wistar) were used to evaluate hematology, blood gases, cardiac markers and lung histopathology changes caused by this parasite. Of them, 60 were individually infected by orogastric gavage with 100 L(3) larvae and 10 uninfected animals formed the control group. The results obtained demonstrate that infection caused by A. cantonensis in R. norvegicus promotes significant hematological changes induced in the vertebrate host, manifested mainly in the form of regenerative anemia, thrombocytopenia and eosinophilia. Additionally, histopathological changes in the lung parenchyma demonstrated in rodents reveal the occurrence of areas of necrosis and extensive fibrosis, being directly related to the development of cellular hypoxia and enzyme cardiac changes. This study can contribute to a better understanding of the relationship between A. cantonensis and R. norvegicus.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Garcia JS,Dos Santos Bonfim TC,Junior AM,Tunholi VM,Tunholi-Alves VM,Mota EM,Simões Rde O,Santana AC,Hooper C,Pinheiro J,Bóia MNdoi
10.1016/j.parint.2014.04.008subject
Has Abstractpub_date
2014-08-01 00:00:00pages
631-7issue
4eissn
1383-5769issn
1873-0329pii
S1383-5769(14)00056-7journal_volume
63pub_type
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