Abstract：
:Gametocytocidal activities of pyronaridine and DNA topoisomerase II inhibitors against two isolates of multidrug-resistant Plasmodium falciparum, KT1 and KT3 were determined. After sorbitol treatment, pure gametocyte cultures of Plasmodium falciparum containing mostly young gametocytes (stage II and III) obtained on day 11 were exposed to the drugs for 48 h. The effect of the drugs on gametocyte development was assessed by counting gametocytes on day 15 of culture. Pyronaridine was the most effective gametocytocidal drug against P. falciparum isolates KT1 and KT3 with 50% inhibitory concentration of 6 and 20 nM, respectively. Moreover, the 50% inhibitory concentration of pyronaridine was lower than that of primaquine which is the only drug used to treat malaria patients harboring gametocytes. Prokaryotic (norfloxacin) and eukaryotic (amsacrine and etoposide) DNA topoisomerase II inhibitors were only effective against asexual but not sexual stages of the malaria parasites. Pyronaridine has both schizontocidal and gametocytocidal activities against the human malaria parasite, P. falciparum.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Chavalitshewinkoon-Petmitr P,Pongvilairat G,Auparakkitanon S,Wilairat Pdoi
10.1016/s1383-5769(99)00028-8subject
Has Abstractpub_date
2000-02-01 00:00:00pages
275-80issue
4eissn
1383-5769issn
1873-0329pii
S1383576999000288journal_volume
48pub_type
杂志文章abstract：:The stomach bot fly species in Asian elephants has long been known as Cobboldia elephantis. However, there is no genetic information available for this species to date. Here, we report that a third-instar fly larva was excreted from a captive Asian elephant four months after export from an elephant camp in Myanmar to ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.102035
更新日期：2020-04-01 00:00:00
abstract：:In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a closely related Apicompl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.08.006
更新日期：2015-02-01 00:00:00
abstract：:Neosporosis caused by Neospora caninum is a serious disease in cattle and dogs worldwide. It is the major cause of abortion and neonatal mortality in cattle. In this study, we evaluated the anti-N. caninum activity of Chinese medicine extracts (curcumin, artemether), herbicides (atrazine, glyphosate), anticoccidiosis ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.08.002
更新日期：2015-12-01 00:00:00
abstract：:Several Sarcocystis spp. have carnivores as definitive host and sarcocysts are common in muscles of herbivores (intermediate host). However, sarcocysts have been found in muscles of wild and domestic carnivores suggesting they are intermediate host for some Sarcocystis spp. Here, we report mature sarcocysts in the mus...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.01.021
更新日期：2017-06-01 00:00:00
abstract：:A strategy to engineer a strain of Culex mosquitoes refractory to filarial transmission is described. A requirement for success of the strategy is identification of a flight muscle-specific promoter that functions in the mosquito. A GFP marker gene under the control of the promoter region of the Drosophila melanogaste...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2004.04.002
更新日期：2004-12-01 00:00:00
abstract：:Human intestinal sarcocystosis (HIS), caused by Sarcocystis species, is acquired by eating undercooked meat from sarcocyst-containing cattle (S. hominis, S. heydorni) and pigs (S. suihominis). We report on the detection of human intestinal Sarcocystis infections in a cross-sectional survey of Strongyloides stercoralis...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.04.010
更新日期：2017-10-01 00:00:00
abstract：:In this work, we characterized the gene encoding iron superoxide dismutase-A (FeSOD-A) in wild-type (WTS) and antimony-resistant (SbR) L. (Viannia) braziliensis and L. (Leishmania) infantum lines, which were selected in vitro. FeSOD-A transcript and protein expression were similar in all tested lines; however, specifi...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.001
更新日期：2015-04-01 00:00:00
abstract：:Diplozoids (Diplozoidae, Monogenea) are fish ectoparasites with a direct life cycle without intermediate hosts. Their free swimming larva, the oncomiracidium, hatches from eggs, invades a fish host and metamorphoses into a post-oncomiracidial larval stage, the diporpa. Later, two diporpae fuse and live as a pair in cr...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.01.010
更新日期：2007-09-01 00:00:00
abstract：:Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:The pathogen Borrelia burgdorferi causes Lyme Borreliosis in human and animals world-wide. In Europe the pathogen is transmitted to the host by the vector Ixodes ricinus. The nymph is the primary instar for transmission to humans. We here study the infection rate of five Borrelia genospecies: B. burgdorferi sensu stri...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.07.004
更新日期：2008-03-01 00:00:00
abstract：:Owing to the need to combat the spread of acaricide-resistant ticks, the development of long-term biological control has become a hot topic for tick control. In this study, we investigated the pathogenicity of three Beauveria bassiana isolates on the engorged female Rhipicephalus (Boophilus) microplus ticks using diff...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.04.008
更新日期：2013-10-01 00:00:00
abstract：:The host-parasite relationship is one of the main themes of modern parasitology. Recent revolutions in science, including the development of various fluorescent proteins/probes and two-photon microscopy, have made it possible to directly visualize and study the mechanisms underlying the interaction between the host an...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.02.011
更新日期：2016-10-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.01.009
更新日期：2009-06-01 00:00:00
abstract：:The necropsy of an adult male leopard, Panthera pardus, shot in the Kruger National Park, revealed the presence of large numbers of Armillifer armillatus nymphs in the intestine, liver, spleen, mesentery, peritoneal fold, mediastinum and lungs. The animal had been observed to be blind in the right eye and severely deb...
journal_title：Parasitology international
pub_type：
doi：10.1016/j.parint.2019.102029
更新日期：2020-06-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.01.005
更新日期：2018-06-01 00:00:00
abstract：:The role of neutrophils in mediating host inflammation was examined in mice vaccinated with living third-stage infective hookworm larvae (L3). Mice were vaccinated by oral immunization with 500 L3 (Ancylostoma caninum) once every 2 weeks for a total of three immunizations. The vaccinated mice were then challenged intr...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(01)00081-2
更新日期：2001-11-01 00:00:00
abstract：:The parasite Entamoeba histolytica causes intestinal amebiasis and amebic liver abscess as its main extraintestinal manifestation. To study the in vivo events related to inflammation and the interactions between hosts and parasites during amebiasis, we designed a novel model of host-parasite interactions using cellulo...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.08.009
更新日期：2016-12-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.10.004
更新日期：2017-02-01 00:00:00
abstract：:Gyrodactylus medaka n. sp. (Monogenea: Gyrodactylidae) is described from the skin, fins, and gills of medaka Oryzias latipes (Beloniformes: Adrianichthyidae) from Japan. This new species was collected from wild medaka in Hiroshima, Aichi, Saga, and Kumamoto prefectures, and laboratory-reared medaka in Chiba and Aichi ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.06.010
更新日期：2018-10-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.03.002
更新日期：2006-09-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.08.005
更新日期：2010-12-01 00:00:00
abstract：:Two hyperapolytic species of Acanthobothrium Blanchard, 1848 have been collected from Discopyge tschudii Heckel, 1846 and Zapteryx brevirostris (Müller et Henle) along the coast of Argentina. Acanthobothrium stefaniae sp. n. from D. tschudii is a category one species (i.e., it is less than 15 mm in total length, posse...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.04.001
更新日期：2018-08-01 00:00:00
abstract：:Among natural products, sesquiterpenes have shown promising inhibitory effects against bloodstream forms of Trypanosoma brucei, the protozoan parasite causing human African trypanosomiasis (HAT). Smyrnium olusatrum (Apiaceae), also known as Alexanders or wild celery, is a neglected horticultural crop characterized by ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.01.001
更新日期：2017-04-01 00:00:00
abstract：:The composition, structure and pattern of helminth assemblages associated with the storks (Ciconiidae), ibises and spoonbills (Threskiornithidae) are poorly understood. Here we analyze the prevalence, intensity and diversity of the helminth component communities associated with the white stork Ciconia ciconia and blac...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.004
更新日期：2015-04-01 00:00:00
abstract：:Visceral pentastomiasis (porocephalosis) caused by Armillifer armillatus larvae was incidentally diagnosed in a female striped hyena (Hyaena hyaena) of unknown age which died unexpectedly in 2013. The hyena had been imported from Tanzania 8years earlier and have been since then in a zoo in Chiang Mai, northern Thailan...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.10.004
更新日期：2016-02-01 00:00:00
abstract：:Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multipl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.002
更新日期：2009-12-01 00:00:00
abstract：:Hemoplasmosis caused by Mycoplasma spp. have been associated with major economic losses in the global dairy production. Hemoplasma studies in the Philippines are limited despite its potential impact. This study mainly aimed to detect the presence of hemoplasma species in dairy water buffaloes and cattle and know their...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.02.004
更新日期：2019-06-01 00:00:00
abstract：:Toxoplasma gondii and Neospora caninum are two closely related protozoan parasites which can cause abortion and significant economic losses in sheep and goats. However, it is yet to know whether black-bone sheep and goats are infected with T. gondii and N. caninum in China. In the present investigation, the seropreval...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.102041
更新日期：2020-04-01 00:00:00
abstract：:We describe the cloning of a full length calpain-encoding cDNA constructed from two truncated cDNAs isolated from a cDNA library prepared with mRNA isolated from adult worms of the Philippine strain of Schistosoma japonicum. The cDNA sequence is 2.456 kb in length and predicts a protein of 758 residues with a molecula...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(99)00021-5
更新日期：2000-01-01 00:00:00
abstract：:European liver fluke (Opisthorchis felineus) and Asian liver fluke (Opisthorchis viverrini) are similar in morphology but comparative pathology of the infections has not been described. We therefore did comparative histopathology of both parasites in an experimental animal model. The study was conducted in 3 groups of...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.08.005
更新日期：2012-03-01 00:00:00
