Abstract：
:In this work, we characterized the gene encoding iron superoxide dismutase-A (FeSOD-A) in wild-type (WTS) and antimony-resistant (SbR) L. (Viannia) braziliensis and L. (Leishmania) infantum lines, which were selected in vitro. FeSOD-A transcript and protein expression were similar in all tested lines; however, specific enzyme activity analysis revealed higher superoxide dismutase activity in SbIII-resistant LbSbR and LiSbR lines than in the corresponding WTS lines. These parasites were also more tolerant to oxidative stress generated by the herbicide paraquat. Functional analysis showed that in comparison to non-transfected lines, wild-type LbWTS and LiWTS clones overexpressing the FeSOD-A enzyme are 1.6- and 1.7-fold more resistant to SbIII, respectively. Our results suggest that FeSOD-A is involved in the antimony resistance phenotype in L. (V.) braziliensis and L. (L.) infantum.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Tessarollo NG,Andrade JM,Moreira DS,Murta SMdoi
10.1016/j.parint.2014.11.001subject
Has Abstractpub_date
2015-04-01 00:00:00pages
125-9issue
2eissn
1383-5769issn
1873-0329pii
S1383-5769(14)00147-0journal_volume
64pub_type
杂志文章abstract：:In murine leishmaniasis, the induction of the T-helper type 1 (Th1) response contributes to infection resistance, whereas the establishment of the Th2 response makes the mice susceptible to infection. Interleukin-12 (IL-12) plays a pivotal role in the diversification of immune responses to the Th1 type. In this study,...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(01)00070-8
更新日期：2001-07-01 00:00:00
abstract：:This study was conducted both to assess the prevalence of parasitic infections in two neighboring villages of Manisa province in Turkey, with different socioeconomic levels and investigate the influences of some individual and environmental factors on these infections. A total of 100 school children were enrolled and ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.01.005
更新日期：2007-06-01 00:00:00
abstract：:The present study analyses complement resistance, cell surface carbohydrates expression, lipidic composition and morphology in vivo and in vitro, of Leishmania (Viannia) shawi, a parasite identified in the Amazon region, Pará state, in 1989. We demonstrated that promastigotes in the stationary (STAT) growth phase are ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.01.009
更新日期：2009-06-01 00:00:00
abstract：:Malaria is a disease caused by Plasmodium parasites that affects hundreds of millions of people. Plasmodium proteases are involved in invasion, erythrocyte egress and degradation of host proteins. Falcipains are well-studied cysteine peptidases located in P. falciparum food vacuoles that participate in hemoglobin degr...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.12.005
更新日期：2018-04-01 00:00:00
abstract：:The salivary glands of Rhipicephalus sanguineus males at stages: unfed (control), at day seven post-attachment, and at days three and seven post-detachment from the host were examined using methods of enzymatic analysis and cell viability. At these stages of feeding, different staining patterns were observed in the ce...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2008.04.012
更新日期：2008-09-01 00:00:00
abstract：:A case of fatal infection caused by larval forms of Taenia martis in a ring-tailed lemur (Lemur catta) living in the Rome zoological garden is described. The animal, living in a semi-natural pen with other 15 conspecific individuals and being fed with fresh fruit and vegetables, yoghurt and eggs, was transported to th...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.05.008
更新日期：2014-10-01 00:00:00
abstract：:The anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction (50°C, 150bar) and the chemical compounds isolated and purified from this extract (benzopyrans HP1, HP2, HP3, and phloroglucinol derivative uliginosin B) were assessed. All samples had anti-T. vaginalis...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.10.006
更新日期：2013-04-01 00:00:00
abstract：:Diphyllobothrium nihonkaiense [Y. Yamane, H. Kamo, G. Bylund, J.P. Wilkgren. Diphyllobothrium nihonkaiense sp. nov (Cestoda: Diphyllobothriidae)- revised identification of Japanese broad tapeworm. Shimane J Med Sci 1986;10:29-48.] and Diphyllobothrium klebanovskii [I.V. Muratov, P.S. Posokhov. Causative agent of human...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2008.09.001
更新日期：2009-03-01 00:00:00
abstract：:Brasicystis bennetti Thatcher, 1979 was first described from specimens obtained from the subcutaneous tissues of the mouth and operculum of Plagioscyion squamosissimus from the Amazon River in Brazil, however since 2008, Brasicystis has been considered a genus inquirendum. This study reviews some of the diagnostic cha...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.01.001
更新日期：2013-04-01 00:00:00
abstract：:Canine hepatozoonosis caused by Hepatozoon canis is a worldwide distributed tick-borne disease of domestic and wild canids that is transmitted by ingestion of Rhipicephalus sanguineus sensu lato (s.l.) ticks. The present study was aimed to determine the prevalence of Hepatozoon infections in 80 stray dogs from Havana ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102200
更新日期：2021-02-01 00:00:00
abstract：:Based on specimens from the gill cavities of one Platichthys stellatus individual collected in the Sea of Japan, we investigated the taxonomic status of the enigmatic caligid genus Pseudolepeophtheirus and its type species, Pseudolepeophtheirus longicauda. In a maximum likelihood (ML) tree based on 18S rRNA gene seque...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102135
更新日期：2020-10-01 00:00:00
abstract：:Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.09.001
更新日期：2013-02-01 00:00:00
abstract：:Schistosomiasis is endemic in Indonesia in two isolated areas, Lindu valley and Napu valley, both located in the Province of Central Sulawesi. In 1940, a prevalence survey was initiated in Lake Lindu, which indicated a Schistosoma japonicum infection prevalence of 56% among the population of Anca, Tomado and Langko vi...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2008.04.008
更新日期：2008-09-01 00:00:00
abstract：:The role of the virulent gene ROP18 polymorphisms is not known in human toxoplasmosis. A total of 320 clinical samples were analyzed. In samples positive for ROP18 gene, we determined by an allele specific PCR, if patients got the upstream insertion positive ROP18 sequence Toxoplasma strain (mouse avirulent strain) or...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.10.012
更新日期：2014-04-01 00:00:00
abstract：:European liver fluke (Opisthorchis felineus) and Asian liver fluke (Opisthorchis viverrini) are similar in morphology but comparative pathology of the infections has not been described. We therefore did comparative histopathology of both parasites in an experimental animal model. The study was conducted in 3 groups of...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.08.005
更新日期：2012-03-01 00:00:00
abstract：:The advances in microscopy combined to the invaluable progress carried by the utilization of molecular, immunological or immunochemical markers and the implementation of more powerful imaging technologies have yielded great improvements to the knowledge of the interaction between microorganisms and their hosts, notabl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.07.011
更新日期：2014-02-01 00:00:00
abstract：:Fasciola flukes from eastern India were characterized on the basis of spermatogenesis status and nuclear ITS1. Both Fasciola gigantica and aspermic Fasciola flukes were detected in Imphal, Kohima, and Gantoku districts. The sequences of mitochondrial nad1 were analyzed to infer their phylogenetical relationship with n...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.04.004
更新日期：2015-10-01 00:00:00
abstract：:In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a closely related Apicompl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.08.006
更新日期：2015-02-01 00:00:00
abstract：:Alleviating morbidity due to lymphatic filariasis (LF)-especially in elderly patients who are rather ignorant-is presently the biggest challenge for the national filariasis campaign. We introduced two follow-up schemes and compared each other to address three key programmatic issues (1) locating patients, (2) educatin...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.11.005
更新日期：2018-04-01 00:00:00
abstract：:The phospholipid metabolism of Plasmodium falciparum-infected erythrocytes has been shown to be an effective pharmacological target for novel chemotherapy. Thirty-seven monoquaternary ammonium derivatives analogous to choline were screened for their potential antiprotozoal activity against P. falciparum and Leishmania...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.09.006
更新日期：2008-06-01 00:00:00
abstract：:Human fascioliasis cases in Japan have been reported infrequently and the most appropriate therapy for this disease remains to be determined. This case report describes a patient with the infection unsuccessfully treated with multiple high doses of praziquantel for over 1 year and eventually cured by the administratio...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(02)00004-1
更新日期：2002-06-01 00:00:00
abstract：:The life cycle of Coitocoecum plagiorchis Ozaki, 1926 (Coitocaecum is an incorrect subsequent spelling) was studied in the field and laboratory. The study was conducted at the Futatsu River and the Chikugo River, Kyushu, Japan. Adults of C. plagiorchis were obtained from fishes Coreoperca kawamebari, Rhinogobius spp. ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2005.06.004
更新日期：2005-12-01 00:00:00
abstract：:Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic functions. PoDHFR-TS w...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.12.004
更新日期：2012-06-01 00:00:00
abstract：:In Shiqu County of the Qinghai-Tibet plateau, many wild and domestic mammals are involved in the transmission cycles of Echinococcus spp. Echinococcus multilocularis and Echinococcus granulosus genotype G1 (sheep strain) are sympatrically distributed in the plateau. In 1995, we identified a unique strobilate stage of ...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.035
更新日期：2006-01-01 00:00:00
abstract：:The composition, structure and pattern of helminth assemblages associated with the storks (Ciconiidae), ibises and spoonbills (Threskiornithidae) are poorly understood. Here we analyze the prevalence, intensity and diversity of the helminth component communities associated with the white stork Ciconia ciconia and blac...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.004
更新日期：2015-04-01 00:00:00
abstract：:Schistosoma mansoni enzymes play important roles in host-parasite interactions and are potential targets for immunological and/or pharmacological attack. The aim of this study was to comparatively assess the presence of hydrolytic activities (phosphatases, glycosidases, aminopeptidases) in soluble (SF) and membrane (M...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.09.015
更新日期：2017-02-01 00:00:00
abstract：:Hydroethidine has been used as a viability dye in various haemoparasites, including Plasmodium species. We compared flow cytometric quantification by hydroethidine and thiazole orange in P. falciparum. Dead parasites that did not develop or replicate exhibited high levels of DNA fragmentation and abnormal microscopic ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.07.002
更新日期：2012-12-01 00:00:00
abstract：:Bovine trypanosomosis is a problem in the livestock industry in Nigeria. A longitudinal survey of cattle sampled during the wet and dry seasons was conducted from April 2016 to March 2017. Blood samples were collected by random sampling from 745 cattle in southwest Nigeria and screened for trypanosomes by internal tra...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:Larval infection with Echinococcus multilocularis starts with the intrahepatic postoncospheral development of a metacestode that-at its mature stage-consists of an inner germinal and an outer laminated layer (GL & LL). In certain cases, an appropriate host immune response may inhibit parasite proliferation. Several li...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.006
更新日期：2006-01-01 00:00:00
abstract：:The asexual erythrocytic cycle of the protozoan parasite Plasmodium falciparum is responsible for the pathogenesis of malaria and causes the overwhelming majority of malaria deaths. Rapidly increasing parasitaemia during this 48hour cycle threatens the survival of the human host and the parasite prior to transmission ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.07.007
更新日期：2016-12-01 00:00:00
