Abstract：
:Leishmaniasis is one of the major infectious diseases affecting the poorest regions of the world. The present study evaluated the antileishmanial activity of a guaianolide purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium (L.) Schultz Bip. The isolated compound showed activity against the promastigote form of Leishmania amazonensis, with 50% inhibition (IC(50)) of cell growth at a concentration of 2.6 μg/ml. For the intracellular amastigote form, this guaianolide reduced by 10% the survival index of parasites in macrophages when it was used at 20.0 μg/ml. The selective index (SI) ratio (CC(50) for J774G8 cells/IC(50) for protozoans) was 385, showing that it is more selective against the parasite than mammalian cells. Morphological alterations of protozoans treated with IC(50) included changes in size, shape, and structure (more than one nucleus and flagellum) under both light and scanning electron microscopies.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
da Silva BP,Cortez DA,Violin TY,Dias Filho BP,Nakamura CV,Ueda-Nakamura T,Ferreira ICdoi
10.1016/j.parint.2010.08.005subject
Has Abstractpub_date
2010-12-01 00:00:00pages
643-6issue
4eissn
1383-5769issn
1873-0329pii
S1383-5769(10)00136-4journal_volume
59pub_type
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