Abstract：
:The antimalarial activity of the hot-water extract of Hydrangea macrophylla var. Otaksa leaves was evaluated against Plasmodium yoelii 17XL in mice. Non-treated control mice died from 6 to 7 days after infection, but mice treated with the leaf extract survived during the experiment. Mice given the extract orally showed low parasitemia levels during administration. Following a transient recrudescence of malaria parasites in the bloodstream of treated mice, no parasites could be detected by a microscopic examination. Furthermore, the 30% MeOH aq. eluate and 50% MeOH aq. eluate from dried leaves of H. macrophylla var. Otaksa showed an antimalarial activity in vivo. Sulfamonomethoxine was orally given to infected mice to compare with the antimalarial activity of the hot-water extract of leaves. Sulfamonomethoxine given orally reduced parasitemia, but no complete cure of mice was observed.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Ishih A,Ikeya C,Yanoh M,Takezoe H,Miyase T,Terada Mdoi
10.1016/s1383-5769(00)00069-6subject
Has Abstractpub_date
2001-03-01 00:00:00pages
33-9issue
1eissn
1383-5769issn
1873-0329pii
S1383-5769(00)00069-6journal_volume
50pub_type
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