Abstract：
:mRNA and protein expression profiles for three peroxiredoxins (TPx-1, TPx-2 and 1-Cys Prx) of liver stage Plasmodium berghei were examined through quantitative reverse transcription-PCR (RT-PCR) and indirect immunofluorescence microscopy assay (IFA). RT-PCR experiments revealed that mRNA expression for the TPx-1 was detected shortly after the sporozoite infection and kept expressed until the schizont stage. In contrast, the mRNA expression for 1-Cys Prx had begun increasing when the parasite developed into the schizont stage. Using the IFA, TPx-1 and 1-Cys Prx were detected in the cytosol. This finding suggested the developmental stage-specific expression of the cytosolic enzymes in the liver stage parasite. On the other hand, the mRNA expression for TPx-2 had begun increasing at the trophozoite stage and peaked at the schizont stage. In the IFA, TPx-2 was found localized in the mitochondria. The increase of TPx-2 might be explained by the exponential development of the parasite during the schizont stage requiring ATP production which may induce reactive oxygen species (ROS) in the mitochondria.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Usui M,Masuda-Suganuma H,Fukumoto S,Angeles JM,Inoue N,Kawazu Sdoi
10.1016/j.parint.2012.11.007subject
Has Abstractpub_date
2013-06-01 00:00:00pages
337-40issue
3eissn
1383-5769issn
1873-0329pii
S1383-5769(12)00159-6journal_volume
62pub_type
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