Abstract:
:Opisthorchiasis caused by the carcinogenic liver fluke Opisthorchis viverrini is a major foodborne parasitic zoonotic disease in Thailand and neighboring Mekong countries. The infection is associated with several hepatobiliary diseases including cholangiocarcinoma (CCA). The rates of CCA in regions where the parasite is endemic are unprecedented. Extensive research on various aspects of opisthorchiasis has been conducted in recent decades. However, the current status of O. viverrini infection in the country is approaching 85% prevalence in certain endemic areas even after more than 30years of control programs in Thailand. The complex life cycle of the fluke, which involves several hosts/environments, makes it difficult to control by conventional methods. Therefore, a new control strategy using the EcoHealth/One Health approach named the "Lawa model" was introduced into the liver fluke endemic Lawa Lake region in Khon Kaen Province. This program has been underway for over ten years. The program includes treatment with anthelmintic drugs, novel intensive health education methods both in the communities and in schools, ecosystem monitoring and active community participation. We developed the "Liver fluke-free school program" as a part of the Lawa model with successful results. All key stakeholders were empowered to obtain competency in their control activities for the sustainability of the program in the community. Nowadays, the infection rate in the 12 villages surrounding the lake has declined to less than 10% from an average of 60% at the start. The Cyprinid fish species now show less than 1% prevalence of infection compared with a maximum of 70% during the baseline survey. No infected Bithynia snails in the lake were found during recent field studies. Of the lessons learned from the Lawa model, the importance of community participation is one practical and essential component. The key to the success of the project is multi-stakeholder participation with the active local Health Promoting Hospitals and the village health volunteers. The idea of the Lawa model is on the national agenda against liver fluke infection and CCA and is being scaled up to work in larger areas in Thailand. Internationally, the "Lawa model" is one of two programs that are showcased as successful control programs for helminths by the WHO Neglected Zoonotic Diseases (NZD4). Several media outlets have broadcast news reports about the program.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Sripa B,Tangkawattana S,Sangnikul Tdoi
10.1016/j.parint.2016.11.013subject
Has Abstractpub_date
2017-08-01 00:00:00pages
346-354issue
4eissn
1383-5769issn
1873-0329pii
S1383-5769(16)30503-7journal_volume
66pub_type
杂志文章,评审abstract::Human intestinal sarcocystosis (HIS), caused by Sarcocystis species, is acquired by eating undercooked meat from sarcocyst-containing cattle (S. hominis, S. heydorni) and pigs (S. suihominis). We report on the detection of human intestinal Sarcocystis infections in a cross-sectional survey of Strongyloides stercoralis...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.04.010
更新日期:2017-10-01 00:00:00
abstract::The necropsy of an adult male leopard, Panthera pardus, shot in the Kruger National Park, revealed the presence of large numbers of Armillifer armillatus nymphs in the intestine, liver, spleen, mesentery, peritoneal fold, mediastinum and lungs. The animal had been observed to be blind in the right eye and severely deb...
journal_title:Parasitology international
pub_type:
doi:10.1016/j.parint.2019.102029
更新日期:2020-06-01 00:00:00
abstract::We present evidence demonstrating that genes encoding enzymes essential for successful blood-feeding are differentially induced in the midgut of the hard tick Haemaphysalis longicornis. Three serine proteinase genes (HlSP, HlSP2 and HlSP3) isolated from H. longicornis midgut exhibit protein sequence similarity with ot...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2008.08.003
更新日期:2008-12-01 00:00:00
abstract::Hydroethidine has been used as a viability dye in various haemoparasites, including Plasmodium species. We compared flow cytometric quantification by hydroethidine and thiazole orange in P. falciparum. Dead parasites that did not develop or replicate exhibited high levels of DNA fragmentation and abnormal microscopic ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2012.07.002
更新日期:2012-12-01 00:00:00
abstract::The parasite Giardia intestinalis undergoes a differentiation process that allows it to infect its mammal host. That process is excystation. We examined the importance of protein phosphorylation during the passage from cyst to trophozoite. Cysts obtained from patients with giardiasis were excysted in vitro and the sol...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.10.005
更新日期:2010-03-01 00:00:00
abstract::The association between liver fluke infection caused by Opisthorchis viverrini and cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium) has been well established. Multiple mechanisms play a role in the development of CCA, but the excretory/secretory products released by O. viverrini (OvES) represent t...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2016.02.001
更新日期:2017-08-01 00:00:00
abstract::A series of sixteen benzoylthioureas derivatives were initially evaluated in vitro against the epimastigote form of Trypanosoma cruzi. All of the tested compounds inhibited the growth of this form of the parasite, and due to the promising anti-epimastigote activity from three of these compounds, they were also assayed...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102225
更新日期:2021-02-01 00:00:00
abstract::Giardia intestinalis (G. intestinalis) is a flagellate parasite which has been considered the most common protozoan infecting human. Molecular techniques are of great value in studying the taxonomy, the zoonotic potential of animal isolates and the correlation between the genetic variability of the parasite and the ra...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2011.09.006
更新日期:2011-12-01 00:00:00
abstract::Toxoplasma gondii takes two different life cycle stages within intermediate hosts including humans. Tachyzoites proliferate during the acute stage, and they transform into cysts to establish a chronic infection preferentially in the brain. IFN-γ production by infiltrated CD4+ and CD8+ T cells is required for the preve...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2019.102030
更新日期:2020-06-01 00:00:00
abstract::Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the surface of parasitized red blood cells (PRBCs) mediate adhesion of PRBCs to host vascular endothelial receptors and is considered responsible for pathogenesis of severe P. falciparum malaria. The present study was undertaken to measure cell...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2006.11.003
更新日期:2007-03-01 00:00:00
abstract::Brazilian sardine is emerging as a promising species in Aquaculture. This study describes for the first time a case of parasitic infestation by Amyloodinium in Brazilian sardines Sardinella brasiliensis obtained from natural spawning in captivity. The sardines kept in nurseries were naturally parasitized by the amylod...
journal_title:Parasitology international
pub_type:
doi:10.1016/j.parint.2020.102091
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to determine the prevalence and significance of intestinal protozoa, specially Blastocystis spp., and to perform PCR-based subtype classification for understanding the importance of Blastocystis spp. in the pathogenesis of gastrointestinal disorders in post-traumatic splenectom...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2015.12.004
更新日期:2016-12-01 00:00:00
abstract::Toxoplasmosis is a concern in both human and veterinary medicine, and the consumption of undercooked meat infected with Toxoplasma gondii is a major risk factor in human infection. Establishing the prevalence of the parasite in food-producing livestock is essential to reduce the risk of human infection. This study aim...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2015.07.004
更新日期:2015-12-01 00:00:00
abstract::The life cycle of Coitocoecum plagiorchis Ozaki, 1926 (Coitocaecum is an incorrect subsequent spelling) was studied in the field and laboratory. The study was conducted at the Futatsu River and the Chikugo River, Kyushu, Japan. Adults of C. plagiorchis were obtained from fishes Coreoperca kawamebari, Rhinogobius spp. ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2005.06.004
更新日期:2005-12-01 00:00:00
abstract::The composition, structure and pattern of helminth assemblages associated with the storks (Ciconiidae), ibises and spoonbills (Threskiornithidae) are poorly understood. Here we analyze the prevalence, intensity and diversity of the helminth component communities associated with the white stork Ciconia ciconia and blac...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2014.11.004
更新日期:2015-04-01 00:00:00
abstract::Adult specimens of Corynosoma australe Johnston, 1937 were recorded from the intestines of California sea lions, Zalophus californianus (Lesson), from Baja California Peninsula, Mexico, whereas larval forms were collected from two fish species on the Argentinian coast. Adult specimens of C. australe were morphological...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102205
更新日期:2021-02-01 00:00:00
abstract::A strategy to engineer a strain of Culex mosquitoes refractory to filarial transmission is described. A requirement for success of the strategy is identification of a flight muscle-specific promoter that functions in the mosquito. A GFP marker gene under the control of the promoter region of the Drosophila melanogaste...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2004.04.002
更新日期:2004-12-01 00:00:00
abstract::The presence of iron in the extracellular medium is essential for both in vivo and in vitro survival of pathogenic microorganisms, including Trichomonas vaginalis and Tritrichomonas foetus. In these parasites, iron is directly involved in the proliferation, protein expression and activation of critical enzymes. The pu...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2006.08.002
更新日期:2006-12-01 00:00:00
abstract::Neosporosis caused by Neospora caninum is a serious disease in cattle and dogs worldwide. It is the major cause of abortion and neonatal mortality in cattle. In this study, we evaluated the anti-N. caninum activity of Chinese medicine extracts (curcumin, artemether), herbicides (atrazine, glyphosate), anticoccidiosis ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2015.08.002
更新日期:2015-12-01 00:00:00
abstract::Neospora caninum is an important cause of abortion in cattle worldwide. Dogs act as final hosts shedding oocysts in the environment. They can also harbour the extraintestinal stage of the parasite and this may be associated with a fairly rare neuromuscular condition. The sera of 781 dogs from the Algiers District were...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.08.008
更新日期:2009-12-01 00:00:00
abstract::The present work provides a detailed morphological and molecular description of Anoplocephala manubriata in elephants. Adult worms were recovered during an autopsy of a wild elephant in Elephant Transit Home, Udawalawe, Sri Lanka. Necropsy findings revealed a severe cestode infection in the small intestine. These tape...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.02.007
更新日期:2017-06-01 00:00:00
abstract::We report here the molecular characterization and possible function of a cysteine protease (termed HlCPL-A) identified in the midgut of the hard tick Haemaphysalis longicornis. HlCPL-A is a 333 amino acid protein belonging to the papain family of the cysteine protease. A construct encoding proHlCPL-A was expressed in ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.05.003
更新日期:2009-09-01 00:00:00
abstract::The antimalarial activity of the hot-water extract of Hydrangea macrophylla var. Otaksa leaves was evaluated against Plasmodium yoelii 17XL in mice. Non-treated control mice died from 6 to 7 days after infection, but mice treated with the leaf extract survived during the experiment. Mice given the extract orally showe...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(00)00069-6
更新日期:2001-03-01 00:00:00
abstract::The presence of antibodies to Toxoplasma gondii in livestock and poultry was investigated by latex agglutination tests; samples that agglutinated at dilutions of 1:64 or higher were regarded as positive. Sera were collected from fattening beef cattle (102 Japanese black, 105 crossbreeds and 114 castrated Holstein), cu...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2014.04.003
更新日期:2014-08-01 00:00:00
abstract::Trophozoites of the free-living amoeba, Naegleria fowleri, were isolated from the cerebrospinal fluid of meningoencephalitis patient. The infecting agent was identified as N. fowleri based on morphologic, serologic and molecular techniques carried out on the isolated organisms. ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2005.06.001
更新日期:2005-12-01 00:00:00
abstract::Toxoplasma gondii is a protozoan parasite that infects a wide variety of warm-blooded animals and humans, in which it causes opportunistic disease. As an obligate intracellular parasite, T. gondii must invade a host cell to survive and replicate during infection. Recent studies suggest that T. gondii secretes a variet...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/s1383-5769(98)00042-7
更新日期:1999-03-01 00:00:00
abstract::Due to the increasing development of anthelmintic resistance in nematodes worldwide, it is important to search for anthelmintic compounds with new modes of action and also to investigate the possibility to combine compounds with possible synergistic effects. There might also be the chance to take advantage of the fact...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2013.05.006
更新日期:2013-12-01 00:00:00
abstract::Except for imported cases, we have had no new Schistosoma japonicum infection in Japan since 1977. But there are still two habitats of the intermediate snail host: Oncomelania nosophora in the previous endemic areas of Kofu Basin and Obitsu. O. nosophora from Kofu Basin and Obitsu are susceptible to Chinese and Philip...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/s1383-5769(03)00058-8
更新日期:2003-12-01 00:00:00
abstract::It has been reported that three human Taenia species are distributed in Indonesia: Taenia solium, Taenia asiatica and Taenia saginata. T. asiatica is well known in North Sumatra, especially on Samosir island in Lake Toba. T. solium and T. saginata are known from Bali. T. solium is most serious public health issue in P...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2005.11.024
更新日期:2006-01-01 00:00:00
abstract::Dientamoeba fragilis is an intestinal protozoan, an inhabitant of the human gastrointestinal tract, with a worldwide distribution. The reported prevalence of D. fragilis varies worldwide in different populations between 0.3% and 82.9%, and its role as a pathogen is still unclear. The parasite has been identified in th...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102227
更新日期:2021-02-01 00:00:00