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Plasma big endothelin-1 levels at admission and future cardiovascular outcomes: A cohort study in patients with stable coronary artery disease.

Abstract：

BACKGROUND:Big endothelin-1 (ET-1) has been proposed as a novel prognostic indicator of acute coronary syndrome, while its predicting role of cardiovascular outcomes in patients with stable coronary artery disease (CAD) is unclear. METHODS AND RESULTS:A total of 3154 consecutive patients with stable CAD were enrolled and followed up for 24months. The outcomes included all-cause death, non-fatal myocardial infarction, stroke and unplanned revascularization (percutaneous coronary intervention and coronary artery bypass grafting). Baseline big ET-1 was measured using sandwich enzyme immunoassay method. Cox proportional hazard regression analysis and Kaplan-Meier analysis were used to evaluate the prognostic value of big ET-1 on cardiovascular outcomes. One hundred and eighty-nine (5.99%) events occurred during follow-up. Patients were divided into two groups: events group (n=189) and non-events group (n=2965). The results indicated that the events group had higher levels of big ET-1 compared to non-events group. Multivariable Cox proportional hazard regression analysis showed that big ET-1 was positively and statistically correlated with clinical outcomes (Hazard Ratio: 1.656, 95% confidence interval: 1.099-2.496, p=0.016). Additionally, the Kaplan-Meier analysis revealed that patients with higher big ET-1 presented lower event-free survival (p=0.016). CONCLUSIONS:The present study firstly suggests that big ET-1 is an independent risk marker of cardiovascular outcomes in patients with stable CAD. And more studies are needed to confirm our findings.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Zhou BY,Guo YL,Wu NQ,Zhu CG,Gao Y,Qing P,Li XL,Wang Y,Dong Q,Liu G,Xu RX,Cui CJ,Sun J,Li JJ

doi

10.1016/j.ijcard.2016.12.082

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

76-79

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)34573-9

journal_volume

230

pub_type

杂志文章

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