Abstract:
BACKGROUND:Limited data exists on the impact of sex on clinical characteristics and outcomes among nonvalvular AF patients from China. We investigated the impact of gender on risk factors and inpatient mortality in a hospitalized nonvalvular AF cohort in Nanchang, China. METHODS:We studied consecutive patients hospitalized with nonvalvular AF between May 2011 and December 2013. Predictors of inpatient mortality were evaluated using multivariate regression analyses. RESULTS:We studied 2442 patients (43.7% female; mean age 71.8), with a median hospital stay of 10 days (IQR: 7-14). Inpatient mortality was 2.2%. Mean age, CHADS2 and CHA2DS2-VASc scores were higher in females vs. males (all p<0.0001). Oral anticoagulation use during hospitalization was 33.3% without sex differences, and length of stay and inpatient outcomes were comparable between sexes. On multivariate analyses, the significant risk factors of inpatient death in females were previous ischemic stroke/transient ischemic attack (TIA)/thromboembolism (TE) (Odds Ratio (OR): 2.27; 95% Confidence Intervals (CI): 1.43-3.61), peripheral artery disease (OR: 5.75, 95% CI: 1.49-22.16) and chronic renal disease (OR: 5.68, 95% CI: 1.46-22.13). Among males, only age (OR: 1.06, 95% CI: 1.02-1.11) and previous ischemic stroke/TIA/TE (OR: 1.81, 95% CI: 1.25-2.63) were independent predictors of inpatient mortality. CONCLUSION:Sex related differences in clinical characteristics and stroke risk profile were evident in Chinese nonvalvular AF patients, but no sex disparity was evident in the low antithrombotic therapy use or inpatient mortality. Previous ischemic stroke/TIA/TE was an important predictor of inpatient mortality in both female and male patients.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Xiong Q,Shantsila A,Lane DA,Zhou Q,Liu Y,Shen Y,Cheng X,Hong K,Lip GYdoi
10.1016/j.ijcard.2015.08.076subject
Has Abstractpub_date
2015-12-15 00:00:00pages
195-9eissn
0167-5273issn
1874-1754pii
S0167-5273(15)30304-1journal_volume
201pub_type
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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pub_type: 信件
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更新日期:2008-02-20 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0167-5273(97)00263-5
更新日期:1998-01-05 00:00:00
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更新日期:1994-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.01.132
更新日期:2016-03-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,meta分析,评审
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pub_type: 信件
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更新日期:2008-11-28 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2012.11.033
更新日期:2013-09-30 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-08-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/0167-5273(91)90129-d
更新日期:1991-01-01 00:00:00
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journal_title:International journal of cardiology
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更新日期:2009-11-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(97)00267-2
更新日期:1998-01-05 00:00:00
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pub_type: 杂志文章
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更新日期:1998-02-28 00:00:00