Abstract:
BACKGROUND:We have previously reported that transient myocardial ischemia induced during exercise or dipyridamole challenge leads to the release of increased amounts of hydrogen peroxide into circulating blood. It would indicate that the temporary functional changes within myocardial cells may constitute there a sterile inflammatory area. Therefore we decided to evaluate the chemotactic properties of plasma in patients undergoing dipyridamole provocative test, as a sign of released inflammatory mediators. The ischemia occurrence was evaluated with 99mTc-SestaMIBI followed by single photon emission computed tomography (SPECT). METHODS:Blood samples were obtained from the peripheral vein of 42 patients (18 men and 24 women, mean age 61 years). Plasma chemotactic activity was determined by the use of the Boyden chamber method: immediately before dipyridamole challenge (time 0), 7, and 30 min after drug infusion. The migration of control polymorphonuclear neutrophils towards evaluated plasma samples was estimated. RESULTS:Chemotaxis of control PMNs towards plasma isolated from patients without signs of myocardial ischemia 7 min after dipyridamole administration was significantly diminished in comparison with baseline values (p=0.003). Plasma obtained 7 min after dipyridamole infusion from patients manifesting signs of myocardial ischemia by SPECT attracted control PMNs significantly more intensively in comparison to plasma isolated at time 0 (p=0.0005). CONCLUSIONS:The obtained results indicate that transient myocardial ischemia induced by dipyridamole challenge leads to generation of chemotactic factors detectable in peripheral blood plasma.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Wysocki H,Kazmierczak M,Wykretowicz A,Szczepanik A,Minczykowski Adoi
10.1016/s0167-5273(97)00267-2subject
Has Abstractpub_date
1998-01-05 00:00:00pages
15-9issue
1eissn
0167-5273issn
1874-1754pii
S0167527397002672journal_volume
63pub_type
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:International journal of cardiology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(97)00153-8
更新日期:1997-09-19 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-06-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.08.037
更新日期:2006-06-16 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2004.08.010
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.01.052
更新日期:2010-08-06 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:2008-03-14 00:00:00
abstract:BACKGROUND:Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::We investigated the influence of Holter duration on the detection of recurrences after ablation for atrial fibrillation (AF). Two-hundred-and-fifteen patients underwent a 7-day Holter ECG at 6 months after catheter ablation. We analyzed the number of patients who had a recurrence within the first 24, 48, 72 h etc. up ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.10.004
更新日期:2010-03-18 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(00)00414-9
更新日期:2001-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2011.08.059
更新日期:2012-09-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.07.135
更新日期:2018-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.05.033
更新日期:2018-11-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.11.113
更新日期:2013-09-30 00:00:00