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A critical review on the translational journey of cardioprotective therapies!

Abstract：

:The failure to translate novel cardioprotective therapies tested in pre-clinical studies into the clinical setting for patient benefit can be attributed to a number of factors at different stages of the research process. This review focuses on the evidences and the gaps with regard to the translational journey of cardioprotective interventions. Gaps are classified into 3 main groups: 1) those related to pre-clinical studies, 2) those associated with the validation of infarct size as a good surrogate and 3) those based on design and interpretation of randomized clinical trials on cardioprotection. Addressing these gaps might increase the chances to successfully translate cardioprotective therapies into improving both post-STEMI heart failure and cardiovascular death rates.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Rossello X,Yellon DM

doi

10.1016/j.ijcard.2016.06.131

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

176-84

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)31141-X

journal_volume

220

pub_type

杂志文章,评审

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