Abstract:
:Unraveling the mechanisms underlying Takotsubo (TTS) leads to question the current inclusion of the condition within the spectrum of cardiomyopathies. Indeed, the clinical presentation and pathophysiology of TTS clearly differ from cardiomyopathies, i.e. diseases of heart muscle unexplained by abnormal loading conditions or coronary artery disease, which cannot recover spontaneously and may cause sudden death often in minimally symptomatic individuals or result in a gradual deterioration in ventricular function and end-stage heart failure. Furthermore, the term 'cardiomyopathy' can no longer be applied when functional or morphologic abnormalities of the coronary arteries leading to acute myocardial ischemia are deemed responsible for left ventricular (LV) systolic dysfunction. After 27years of investigation, time has come to recognize that patients with TTS do suffer from severe myocardial ischemia and fulfill all criteria of acute coronary syndromes, i.e. acute chest pain, typical electrocardiographic changes, cardiac troponin rise, as well as LV wall motion abnormalities. Accordingly, we propose that TTS should be labeled as an acute 'syndrome' to be included more appropriately within the spectrum of ischemic heart disease. With regard to the term 'stress', it may imply that the catecholamine surge is essential to produce the typical transient myocardial injury. Thus, the terminology 'Takotsubo (stress) syndrome' would more accurately reflect recent advances in the pathophysiology.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Pelliccia F,Sinagra G,Elliott P,Parodi G,Basso C,Camici PGdoi
10.1016/j.ijcard.2017.12.009subject
Has Abstractpub_date
2018-03-01 00:00:00pages
250-253eissn
0167-5273issn
1874-1754pii
S0167-5273(17)37259-5journal_volume
254pub_type
杂志文章,评审abstract:BACKGROUND:To clarify the influence of hemoglobin concentration and platelet count on adverse outcomes of Japanese patients with non-valvular atrial fibrillation (NVAF), a post hoc analysis of the J-RHYTHM Registry was performed. METHODS:A consecutive series of outpatients with atrial fibrillation were enrolled from 1...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 信件
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-03-15 00:00:00
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pub_type: 信件
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更新日期:2007-01-18 00:00:00
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