Abstract:
:The purpose of the present study was to assess whether the insertion (I)/deletion (D) polymorphism of the angiotensin converting enzyme (ACE) gene, and the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) were associated with left ventricular dilatation after myocardial infarction. In 103 patients with myocardial infarction, the left ventricular (LV) end-diastolic volume index (EDVI) and the end-systolic volume index (ESVI) were assessed by echocardiography at two time points, namely at 7 +/- 4 days and at 3.9 +/- 1.3 months (mean +/- S.D.) after the infarction. The increases in the LVEDVI and LVESVI on the second echocardiogram were significantly higher in subjects with the DD and ID genotypes than in patients with the II genotype (P < 0.05 and P < 0.005, respectively). Multiple regression analysis revealed that the LVESVI at the first echocardiographic examination and the ACE I/D genotype were significant predictors of the LVEDVI and LVESVI at the second echocardiographic examination. However, the AGT M235T genotype was eliminated. In conclusion, the DD and ID genotypes of the ACE gene were significantly associated with the progression of the LVEDVI and LVESVI after myocardial infarction. The presence of the deletion allele of the ACE gene may be a risk factor of congestive heart failure after a myocardial infarction.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Ohmichi N,Iwai N,Maeda K,Shimoike H,Nakamura Y,Izumi M,Sugimoto Y,Kinoshita Mdoi
10.1016/0167-5273(96)02562-4subject
Has Abstractpub_date
1996-03-01 00:00:00pages
265-72issue
3eissn
0167-5273issn
1874-1754pii
0167527396025624journal_volume
53pub_type
杂志文章abstract:BACKGROUND:Tricyclic antidepressants (TCAs) are still used in 30% of anxiety/depression cases and have been related to increased cardiovascular risk. Newer serotonin/norepinephrine reuptake inhibitors (SSRIs/SNRIs) safety remains conflicting. Our aim was to assess the risk of a first acute coronary syndrome (ACS) in pa...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.04.137
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:Uric acid (UA) has been identified as one major risk factor for cardiovascular diseases. Lowering of serum UA levels improves endothelial function. The present study investigates for the first time concentration-dependent effects of UA on human aortic endothelial cells (HAEC) and the cellular pathways involv...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.07.102
更新日期:2014-10-20 00:00:00
abstract:BACKGROUND:Anticoagulation remains a controversial issue among hyperthyroid patients with atrial fibrillation (AF). We aimed to evaluate the prevalence of the thrombogenic milieu (TM), detected using transesophageal echocardiography (TEE), among patients with AF related to hyperthyroidism, and to correlate these findin...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.053
更新日期:2017-02-01 00:00:00
abstract::Coronary artery stenosis is a major complication of Kawasaki disease (KD). Several interventional methods in treating coronary artery stenosis have been introduced. However, there are few reports on the management of in-stent restenosis after coronary stent implantation in children. Reported is a 10-year-old boy who u...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.09.019
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND/OBJECTIVES:Familial hypercholesterolemia (FH) is a genetic disorder that leads to premature heart disease or stroke if untreated. Statins are effective for individuals with FH but less than 20% of actual cases are diagnosed in the US and many people are not adherent to treatment. Using new knowledge regardin...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.12.070
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Self-reported depressive symptoms and clinical depression after myocardial infarction (MI) are both associated with poor cardiac prognosis. It is important to distinguish between the two when assessing cardiac prognosis, but few studies have done so. The present article evaluates the independent prognostic i...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ijcard.2012.07.002
更新日期:2013-09-10 00:00:00
abstract:BACKGROUND:Adult patients with congenital heart disease under follow-up often need to undergo diagnostic procedures which expose them to radiation. AIM:To evaluate radiation doses in adult patients with congenital heart disease during follow-up. METHODS:Data on diagnostic procedures were used from the European Heart ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.07.012
更新日期:2007-05-31 00:00:00
abstract::Endothelial dysfunction induced by various atherosclerotic risk factors can initiate the process of atherosclerosis. Endothelial progenitor cells (EPCs), which have been considered as the precursor of endothelial cells (ECs), play an important role in the maintenance of endothelial function. The inverse association be...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2008.11.034
更新日期:2009-04-17 00:00:00
abstract:BACKGROUND:Dyspnea on exertion is common to both heart failure (HF) and chronic obstructive pulmonary disease (COPD), and it is important to discriminate whether symptoms are caused by HF or COPD in clinical practice. The ventilatory equivalent for carbon dioxide (V̇E/V̇CO2) slope and V̇E intercept (a reflection of pul...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.09.007
更新日期:2019-01-01 00:00:00
abstract::It is important that a cardiologist knows and recognizes the entity of takotsubo cardiomyopathy or apical ballooning, but remains aware that a subsequent similar episode is not necessarily a recurrence of this syndrome. Relapse may be caused by "classical" coronary atherosclerosis, as described in this case report. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.134
更新日期:2008-07-21 00:00:00
abstract::Beta-blockers, as determined by four landmark placebo-controlled studies, impart a significant survival advantage to the chronic heart failure population. What ancillary benefits might be expected from beta-blockade, in terms of symptom relief and improvement in exercise capacity, is less clear. This situation in part...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/s0167-5273(03)00050-0
更新日期:2003-11-01 00:00:00
abstract::Levosimendan and dobutamine are comparable inotropic drugs as regards their hemodynamic effects and clinical outcomes in decompensated heart failure (HF). The aim of this study was to compare the effects of levosimendan and dobutamine treatment on NT-proBNP levels in patients with decompensated HF. Forty-four patients...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.06.136
更新日期:2008-07-21 00:00:00
abstract::Hypertensive patients with heart abnormalities have increased risk of cardiovascular events. Brain natriuretic peptide is a natriuretic peptide mainly of ventricular origin produced in response to pressure and stretch. We hypothesise that brain natriuretic peptide could be a useful marker of cardiac remodelling in hyp...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00023-6
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:Growth differentiation factor 15 (GDF-15) is a marker of cell senescence. Age is a well-known determinant of GDF-15 levels, yet no study has analyzed the relationship between geriatric conditions and GDF-15. We hypothesize that geriatric conditions reflecting biological age might be stronger determinants of ...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2019.05.034
更新日期:2019-09-01 00:00:00
abstract::A 15-year-old patient is presented with parasystolic ventricular tachycardia which was responsive to oral verapamil. We emphasize the value of verapamil in the treatment of this uncommon arrhythmia. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90300-7
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:ASCOT-BPLA study demonstrates that in hypertensive subjects, atenolol+bendroflumethiazide therapy is associated with higher incidence of adverse cardiovascular outcomes and developing diabetes than an amlodipine+perindopril regimen. This is not explained by changes in blood pressure alone. We hypothesized th...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2008.11.017
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Limited data is available regarding the novel Reveal LinQ (LinQ) which is a new generation implantable loop recorders (ILRs). METHODS:We performed a prospective, observational study of all consecutive patients undergoing conventional (Reveal XT; XT) and LinQ devices at our institution between January 2012...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.04.241
更新日期:2015-07-15 00:00:00
abstract::A case of ventricular noncompaction with Giant P waves and focal atrial tachycardia is presented. A 36-year-old man was admitted to our hospital because of palpitations and a progressive worsening of heart failure. A 12 lead rest electrocardiogram showed large positive waves followed by smaller negative waves in limb ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.149
更新日期:2008-01-11 00:00:00
abstract::Calcium channel blockers (CCBs) have several properties which may have beneficial effects on the development of atherosclerosis. These include inhibition of vascular smooth muscle cell (SMC) proliferation and migration; inhibition of calcium influx into the vascular wall; reduction of extracellular matrix synthesis; p...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/s0167-5273(97)00236-2
更新日期:1997-12-31 00:00:00
abstract::In this case report, we describe a successful percutaneous transluminal coronary angioplasty of an abnormally originating left anterior descending artery from the right sinus of Valsalva. We discuss about the decision making in this rare and challenging case, since there is more than one opinion as to which is the app...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(96)02730-1
更新日期:1996-09-01 00:00:00
abstract::The slow channel calcium blocking drugs have been shown to be efficacious in patients with chronic stable angina. They provide effective first alternative therapy to beta-blockers in preventing recurrent episodes of myocardial ischemia in patients who do not tolerate treatment with beta-blocking drugs because of, for ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(82)90002-x
更新日期:1982-01-01 00:00:00
abstract::Cross-sectional and Doppler echocardiographic characteristics of infective endocarditis are described in six cases following patch closure of a ventricular septal defect. The patients presented to us with fever one to five months after surgery. Five of them also had congestive cardiac failure. Cross-sectional echocard...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90158-7
更新日期:1989-10-01 00:00:00
abstract::Ventricular diverticula are rarely seen congenital malformations. For diagnosis, various imaging tools either invasive or non-invasive have been used. However, gold-standard imaging modality is controversial although echocardiography has been the initial choice of diagnostic tool. ...
journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2009.03.125
更新日期:2011-02-17 00:00:00
abstract::A six-month-old girl presented with heart failure. Cardiac catheterisation showed a ventricular septal defect and an anomaly of the aortic arch complex, which is a challenge to embryologic theory. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90328-2
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Lipid ratios are clinically useful markers of coronary artery disease (CAD) risk. The effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on lipid ratios were investigated in the Measuring Effective Reductions in Cholesterol Using Rosuvastatin TherapY (MERCURY) I trial. METHODS:This trial wa...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ijcard.2004.12.011
更新日期:2005-04-20 00:00:00
abstract:AIMS:Aortic coarctation (CoA) occurs as a "simple" isolated disorder, and in a more "complex" form, combined with associated congenital cardiac abnormalities. Long term outcome of all CoA patients may be complicated by dilatation of the thoracic aorta. The aim of this study was to quantify progressive aortic dilatation...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.02.014
更新日期:2013-08-10 00:00:00
abstract::Revelation of a myocardial bridge has been described at coronary angiography. The pathophysiology of myocardial bridging is incompletely understood. It is sometimes associated with overt pathology, as well as it can just be an incidental finding without any significance. It has been also reported an acute myocardial i...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.07.153
更新日期:2009-02-06 00:00:00
abstract::In conclusion, the data shows that in excellent quality studies such as those obtained in vitro, 3D echocardiography is as accurate in describing the volume of the left ventricle as is angiography. When excellent quality images are obtained, the endocardial wall motion, wall thickening and thinning are better describe...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90180-9
更新日期:1985-01-01 00:00:00
abstract::Andersen–Tawil syndrome (ATS) is a rare hereditary multisystem disorder. Ventricular arrhythmias, periodic paralysis and dysmorphic features constitute the classic triad of ATS symptoms. The expressivity of these symptoms is, however, extremely variable, even within single ATS affected families, and not all ATS patien...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2013.10.010
更新日期:2013-12-05 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the association between antidepressant use and incident coronary heart disease (CHD) events in a sample of individuals without known baseline heart disease. PARTICIPANTS AND METHODS:We studied a group of 970 randomly selected community-dwelling adults in the 1995 Nova Sc...
journal_title:International journal of cardiology
pub_type: 信件,随机对照试验
doi:10.1016/j.ijcard.2009.06.036
更新日期:2010-11-05 00:00:00