Abstract:
:Levosimendan and dobutamine are comparable inotropic drugs as regards their hemodynamic effects and clinical outcomes in decompensated heart failure (HF). The aim of this study was to compare the effects of levosimendan and dobutamine treatment on NT-proBNP levels in patients with decompensated HF. Forty-four patients with decompensated HF and ejection fraction <35% received either a 24-h infusion of levosimendan (n=26) or dobutamine (n=18). NT-proBNP was measured at baseline and 12 h, 24 h and 48 h after the initiation of drug infusion. NT-proBNP levels at baseline, 12 h, 24 h and 48 h were 16,879+/-2437, 16,004+/-2635, 12,881+/-2305 and 11,078+/-2092 pg/ml, respectively, in the levosimendan group and 16,031+/-3463, 15,908+/-3806, 12,271+/-3299 and 14,840+/-4009 pg/ml, respectively, in the dobutamine group. NT-proBNP decreased significantly at 24 h in response to both levosimendan and dobutamine treatment (p<0.01 and p<0.05, respectively) with no significant difference among the treatment groups. In the dobutamine group, NT-proBNP increased at 48 h (p=n.s. vs. baseline), in contrast, NT-proBNP reduction continued for up to 48 h in the levosimendan group (p<0.001 vs. baseline). Although not statistically different, a greater percentage of NT-proBNP reduction was observed with levosimendan treatment at both 24 h (-25+/-7% vs. -20+/-10%) and 48 h (-32+/-7% vs. -20+/-11%) compared to dobutamine. Both levosimendan and dobutamine treatments result in significant reduction of NT-proBNP levels at the end of the 24-h infusion. However, compared to dobutamine, levosimendan has better and prolonged effects on NT-proBNP levels in decompensated HF.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Cavusoglu Y,Tek M,Birdane A,Ata N,Demirustu C,Gorenek B,Unalir A,Timuralp Bdoi
10.1016/j.ijcard.2007.06.136subject
Has Abstractpub_date
2008-07-21 00:00:00pages
e188-91issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(07)01481-7journal_volume
127pub_type
信件abstract:INTRODUCTION:Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement...
journal_title:International journal of cardiology
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更新日期:2015-02-01 00:00:00
abstract::A simple and rapid point-of-care platelet function assay that guides antiplatelet responses to aspirin and clopidogrel may be of great clinical value for the individual tailoring of therapy. The Plateletworks assay is based on single platelet counting and has been described as a promising point-of-care assay for the m...
journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2010-04-01 00:00:00
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journal_title:International journal of cardiology
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更新日期:2020-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90255-4
更新日期:1990-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.02.016
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:The use of bioprostheses for surgical aortic valve replacement increased substantially within the last years. In case of prosthesis failure, re-SAVR is standard of care, whereas valve-in-valve deployment of a transfemoral transcatheter aortic valve prosthesis (VinV-TFAVI) has recently emerged as an alternati...
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pub_type: 杂志文章
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abstract:BACKGROUND:Despite new therapies, the prevalence of heart failure continues to escalate. The prevalence of diabetes, a risk factor for heart failure, also continues to rise. To further understand the increasing prevalence of heart failure, we compared trends in the prevalence of diabetes among individuals with diagnose...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2005-03-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.04.036
更新日期:2009-11-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-06-06 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-03-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.12.061
更新日期:2013-07-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(95)02308-j
更新日期:1995-05-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.12.053
更新日期:2008-03-14 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.01.024
更新日期:2017-03-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.08.008
更新日期:2014-10-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件,评审
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更新日期:2007-01-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1989-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-10-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.02.026
更新日期:2006-03-22 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,评审
doi:10.1016/j.ijcard.2003.12.012
更新日期:2005-02-28 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.009
更新日期:2008-05-23 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00