Abstract：
:A simple and rapid point-of-care platelet function assay that guides antiplatelet responses to aspirin and clopidogrel may be of great clinical value for the individual tailoring of therapy. The Plateletworks assay is based on single platelet counting and has been described as a promising point-of-care assay for the monitoring of the effects of the GP IIb/IIIa antagonists. However, data about its utility and reliability in monitoring the effects of thienopyridines is limited. In the present study we assessed reproducibility of the Plateletworks assay over time. In addition, a comparison between the Plateletworks assay and optical aggregometry was performed in a large cohort of patients on maintenance therapy with aspirin and clopidogrel. The Plateletworks assay demonstrated a good agreement with optical aggregometry in measuring the response to clopidogrel. The results of Plateletworks are, however, highly time dependent which implicates that measurements should be performed within 10 min.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
van Werkum JW,Kleibeuker M,Postma S,Bouman HJ,Elsenberg EH,ten Berg JM,Hackeng CMdoi
10.1016/j.ijcard.2008.10.046subject
Has Abstractpub_date
2010-04-01 00:00:00pages
123-6issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(08)01173-Xjournal_volume
140pub_type
信件abstract：BACKGROUND:Stents are now widely used in Hong Kong and China and there is a clinical impression that restenosis is less common because of the lower prevalence of coronary artery disease and associated risk factors in the Chinese. However, there are no published data on angiographic stent restenosis rates in Chinese pat...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2004.06.001
更新日期：2005-06-22 00:00:00
abstract：AIMS:Suboptimal stent expansion correlates with adverse cardiac events. There is limited information regarding Absorb bioresorbable vascular scaffold (BVS) expansion characteristics. Optical coherence tomography (OCT) allows for high-resolution assessment of plaque morphology, composition and assessment of BVS expansio...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2015.01.033
更新日期：2015-04-01 00:00:00
abstract：:We report the longest duration of implantation of a porcine bioprosthesis in the English language literature--a Carpentier-Edwards valved conduit excised after twenty-five years. This 50-year-old man had undergone a modified Fontan operation for tricuspid atresia. He presented with progressive dyspnea, fatigue and ede...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2006.07.063
更新日期：2007-04-12 00:00:00
abstract：AIMS:Heart failure (HF) is the most common complication of patients with atrial fibrillation (AF), but possible risk factors or health consequences are not well described. Low kidney function is a risk factor for both AF and HF. We evaluated estimated glomerular filtration rate (eGFR) as a predictor of HF in patients w...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.08.003
更新日期：2020-12-01 00:00:00
abstract：AIM:We assessed the impact of race on clinical outcome in the multiracial Singapore congestive heart failure (CHF) population. METHODS:668 CHF patients (Age 66+/-12 years, Ejection fraction 29+/-13%), consisting of Chinese (72%), Malays (17.1%) and Indians (10.9%) were prospectively followed up for 24+/-12 months. Pri...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.12.107
更新日期：2009-05-29 00:00:00
abstract：UNLABELLED:The hemodynamic consequences of atrial fibrillation (AF) may lead to impairment of the left ventricular function and a reduction in exercise capacity. Studies on mechanical and neurohormonal remodelling in patients with AF are becoming increasingly important. The results could possibly enhance treatment stra...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2003.05.033
更新日期：2004-08-01 00:00:00
abstract：:Paroxysmal atrial fibrillation is considered a frequent complication of acute myocardial infarction.It has been rarely reported alternating right and left bundle branch block associated with atrial fibrillation. It has also been rarely reported changing axis deviation with left bundle branch block also during atrial f...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.08.056
更新日期：2009-03-06 00:00:00
abstract：:A 74-year-old patient is presented in whom quinidine-induced torsade de pointes was abolished by the onset of atrial fibrillation with a fast ventricular response. Heart rate acceleration during atrial fibrillation shortened the Q-T interval from 0.68 on admission to 0.44 milliseconds when sinus rhythm was re-establis...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(87)90157-4
更新日期：1987-09-01 00:00:00
abstract：:To evaluate the effects of inotropic stimulation on ventriculo-arterial coupling, we determined both the slope of the end-systolic pressure-volume relationship (ventricular elastance) and the slope of end-systolic pressure-stroke volume relationship (arterial elastance) at rest and during dobutamine infusion (5 microg...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90267-s
更新日期：1991-04-01 00:00:00
abstract：:With the advent of transesophageal echocardiography (TEE), thrombi of the aorta are becoming increasingly recognized as possible sources of systemic emboli. This report describes a 58-year-old woman with multiple unexplained peripheral emboli. A giant thrombus of the descending aorta has been identified as the source ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/s0167-5273(02)00509-0
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Non-cardiac complications, such as hepato-renal and metabolic problems, are emerging late after the Fontan operation due to its unique hemodynamics. Consequently, associations between clinical variables and postoperative outcome may change during the prolonged postoperative course. METHODS AND RESULTS:To de...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.03.001
更新日期：2014-05-01 00:00:00
abstract：:While palliative care is often thought of as only being applicable to dying patients, its focus on symptom alleviation, patient function, and quality of life has much to offer older adults with chronic heart failure. Heart failure worsens patients' health status through patients' symptom burden, functional limitations...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2007.10.005
更新日期：2008-04-10 00:00:00
abstract：:A literature search covering national reports since the first published in Mexico (1957), discloses 237 adults and 55 children with a definitive diagnosis of Takayasu's arteritis. This condition was first recognized by an ophtalmologist in 1946, and it was communicated 10 years after his observation. Since 1957, 11 cl...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/s0167-5273(96)88779-1
更新日期：1996-08-01 00:00:00
abstract：:Based on two case reports, problems of diagnosis and treatment of aortic dissection are discussed. Thrombolytic treatment given to patients with aortic dissection presenting symptoms mimicking acute MI seems to have a fatal outcome. Indications, as well as contra-indications, for thrombolytic therapy are therefore of ...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/0167-5273(93)90095-x
更新日期：1993-11-01 00:00:00
abstract：:ACEI and AT1 receptor antagonists are the drugs most consistently shown to reduce ADMA level in humans. Unfortunately, most of the human studies addressing the effect of pharmacotherapy on ADMA metabolism were accomplished on small patient subgroups and were relatively shortlasting. Besides, L-arginine was rarely meas...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.11.109
更新日期：2010-06-25 00:00:00
abstract：:Previous work from the Departments of Cardiology and Nuclear Medicine, Guy's Hospital, London, has enabled an atlas of the electrocardiographic appearances of ectopics from individual ventricular sites to be compiled. This has been used to investigate the relationship between regions of myocardial ischaemia and the si...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(86)90143-9
更新日期：1986-11-01 00:00:00
abstract：BACKGROUND:The mechanisms of antagonism vary between the angiotensin II type 1 receptor blockers (ARBs): insurmountable antagonism and surmountable antagonism. Recent retrospective observational studies suggest that ARBs may not have equivalent benefits in various clinical situations. The aim of this study was to compa...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2013.07.146
更新日期：2014-01-01 00:00:00
abstract：:Atrial fibrillation (AF) is the most common heart arrhythmia, the risk of which typically increases with age. This condition is commonly associated with major cardiovascular diseases and structural heart damage, while it is rarely observed in healthy young people. However, increasing evidence indicates that paroxysmal...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2016.10.047
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Patients with Fabry disease (FD) develop progressive left ventricular hypertrophy (LVH). In screening studies in patients with LVH, the prevalence of FD ranges from 0 to 12%. This variability is attributable to different factors like diverging inclusion and exclusion criteria, the evaluation of selected popu...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.ijcard.2012.06.069
更新日期：2013-09-10 00:00:00
abstract：BACKGROUND:The role of physical exercise in the prevention and treatment of cardiovascular diseases has been well described, however, elevations in cardionecrotic biomarkers after prolonged exercise (i.e. ultramarathon running) were observed. We aimed at understanding the biochemical, molecular biological, structural a...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.12.045
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Pregnancy is associated with an increased risk of aortic pathology. We sought to assess the feasibility of performing non-contrast 3D steady-state free-precession (SSFP) magnetic resonance angiography (MRA) in pregnant subjects with inherited aortopathy. METHODS:Fifteen pregnant subjects (age 27±4yr) with p...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.05.125
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:To study coronary heart disease (CHD) incidence versus other cause of death using the cumulative incidence function and the competing risks procedures to disentangle the differential role of risk factors for different end-points. MATERIAL AND METHODS:We compared standard Cox and Fine-Gray models among 1677 ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.05.043
更新日期：2016-09-15 00:00:00
abstract：:Over a period of 12 years, two cases of pulmonary arterial aneurysms were encountered in our autopsy data of 13 cases of congenital heart defects with right-sided infective endocarditis. Pulmonary arterial aneurysms are rare lesions and may be categorized as central or peripheral. Although early reports implicated tub...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90247-z
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Gender differences have been reported in patients with acute VTE treated with antithrombotic drugs. OBJECTIVE:To address the relationship between gender and new oral anticoagulants (NOACs), we performed a meta-analysis to evaluate the incidence of recurrent VTE and major plus clinically relevant non-major b...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ijcard.2016.03.086
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that control of cardiovascular risk factors deteriorates among residents after a natural disaster. This study assessed the hypothesis that the prevalence of atrial fibrillation (AF) increased among residents in the evacuation zone of Fukushima prefecture after the Great East Japan...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2015.06.151
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Myeloid differentiation factor-2 (MD-2) has been shown to be an important modulator of the innate immune system, but its role in cardiac diseases is unknown. We investigated whether MD-2 plays a role as risk predictor and contributor in dilated cardiomyopathy (DCM). METHODS AND RESULTS:We included 174 patie...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.06.025
更新日期：2018-11-01 00:00:00
abstract：:The search for a genuine thought in ancient times makes medical archeology part of our contemporary knowledge, not to say a patrimony to be harbored. A Roman encyclopedia is a compilation of the prevailing knowledge of scientific and medical matters at the time. In this paper an original Roman prescription for a speci...
journal_title：International journal of cardiology
pub_type： 传,历史文章,信件
doi：10.1016/j.ijcard.2006.11.049
更新日期：2007-11-15 00:00:00
abstract：:Thienopyridines and aspirin are beneficial in patients undergoing bare-metal stent implantation, and aspirin and clopidogrel treatment have also been proved effective after drug-eluting stent (DES) implantation. However, despite the common substitution of clopidogrel with ticlopidine because of cost or patient intoler...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2005.03.038
更新日期：2006-04-14 00:00:00
abstract：BACKGROUND:Cardiovascular disease has emerged as the world's leading cause of death in the last century. An epidemiological focus of this disease that extends not only beyond the developed world but also far back into antiquity asks new questions about associated risk factors. Ancient mummies found in the Atacama deser...
journal_title：International journal of cardiology
pub_type： 历史文章,杂志文章
doi：10.1016/j.ijcard.2016.08.176
更新日期：2016-11-15 00:00:00
abstract：BACKGROUND:Skeletal muscle atrophy and decreased expression of slow fibers contribute to exercise capacity limitation in Chronic Heart Failure (CHF). Pro-inflammatory cytokines and free radicals worsen muscle damage. In CHF sarcomeric proteins are oxidized with reduction of muscle twitch efficiency, and VO(2)-max. Beta...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2009.02.012
更新日期：2010-08-20 00:00:00
