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Acute and chronic effects of ramipril and captopril in congestive heart failure.

Abstract：

:We studied the acute and long-term effects of ramipril and captopril in 12 patients with moderate to severe congestive heart failure using an open, parallel design. Drug doses were titrated. Compared with baseline values, maximal haemodynamic and humoral effects after the first dose of both angiotensin converting enzyme inhibitors were similar, but the effects of ramipril (5 mg) demonstrated a slower onset of action and a significantly longer duration than captopril (12.5 mg). After 3 months of treatment a single dose of 5 mg ramipril showed the same 24-hour haemodynamic profile as after the first dose, but the hypotensive effect was less marked. There was no plasma accumulation of ramiprilat. Serum creatinine and potassium remained stable, except for one patient whose renal function deteriorated on captopril treatment. Complex ventricular arrhythmias occurred in 11 patients and were unaffected after treatment with ramipril or captopril. Two patients died suddenly during ramipril therapy and one patient during captopril therapy. In summary, ramipril is an effective, long-acting angiotensin converting enzyme inhibitor, producing long-term haemodynamic effects in patients with congestive heart failure. Using an individualised dosage scheme, neither long-lasting hypotension nor deterioration of renal function occurred. No effect on ventricular arrhythmias was seen.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

de Graeff PA,Kingma JH,Viersma JW,Wesseling H,Lie KI

doi

10.1016/0167-5273(89)90330-6

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

59-67

issue

1

eissn

0167-5273

issn

1874-1754

pii

0167-5273(89)90330-6

journal_volume

23

pub_type

临床试验,杂志文章,随机对照试验

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