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Calcitonin gene-related peptide and its specific binding sites in the cardiovascular system of rat.

Abstract：

:The concentration of calcitonin gene-related peptide in rat cardiovascular tissues was determined by a specific and sensitive radioimmunoassay and the distribution of its specific binding sites was assessed by radioligand binding studies. The binding of [125I]calcitonin gene-related peptide to cardiovascular membranes was rapid, saturable, reversible and specific. In atrial membranes a single binding site with high affinity (Kd 1.5 nM) and low capacity (120 fmol/mg protein) was detected. The highest concentrations of both calcitonin gene-related peptide and its binding sites were found in the peripheral and mesenteric arteries. The immunoreactive calcitonin gene-related peptide levels were lower in major vessels and lowest in the heart. The number of calcitonin gene-related peptide specific binding sites also showed a similar pattern with the exception of a high concentration of binding sites present in the atria. These findings, together with the proven vasodilatory activity of calcitonin gene-related peptide, suggest that this peptide has an important role as a modulator of peripheral vascular tone and perhaps a direct action of the heart.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Wimalawansa SJ,MacIntyre I

doi

10.1016/0167-5273(88)90313-0

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

29-37

issue

1

eissn

0167-5273

issn

1874-1754

pii

0167-5273(88)90313-0

journal_volume

20

pub_type

杂志文章

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