Abstract:
BACKGROUND:Increased risk of death in patients with primary hyperparathyroidism (PHPT) is referred to cardiovascular complications induced by hypercalcemia. At the moment the role of bioelectrical risk and of enhanced sympathetic activity, not related to cardiovascular complications, is unknown in PHPT patients. METHODS:The study was designed to evaluate the QT parameters and sympathovagal balance in 28 PHPT uncomplicated patients compared to 29 healthy subjects (HS). Nine of 28 patients were restudied after parathyroidectomy. Standard ECG, short and 24-h ECG monitoring were performed to calculate QT parameters and Heart Rate Variability (HRV). RESULTS:QTc interval resulted shorter in PHPT patients than in HS and QTc dispersion resulted higher in PHPT patients than HS. The physiological adaptation of QT length to R-R interval was lacking in PHPT patients. Enhanced sympathetic tone was found in PTHP patients than controls. These data were confirmed after parathyroidectomy. CONCLUSION:Our findings revealed an increased risk to develop life-threatening arrhythmias in PHPT patients due to bioelectrical instability induced by hypercalcemia. Parathyroidectomy doesn't seem to reverse this abnormality.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Curione M,Letizia C,Amato S,Di Bona S,Di Fazio F,Minisola S,Mazzuoli G,D'Erasmo Edoi
10.1016/j.ijcard.2006.08.072subject
Has Abstractpub_date
2007-10-01 00:00:00pages
200-2issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(06)01154-5journal_volume
121pub_type
信件abstract::To examine whether smoking cessation would improve the short-term prognosis for patients with variant angina, 37 smokers with variant angina who were discharged after the complete disappearance of angina by medical treatment with calcium blockers were advised to stop smoking and were followed-up for 1 year. Urinary co...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)90019-1
更新日期:1994-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(96)02853-7
更新日期:1997-01-31 00:00:00
abstract:BACKGROUND:Cell adhesion molecules (CAM) play an important role in the pathogenesis of atherosclerosis by mediating the binding of leukocytes to the endothelium. Soluble CAM isoforms are known to be elevated in the sera of patients suffering from coronary artery disease (CAD). METHODS:We measured the concentrations of...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.01.042
更新日期:2006-01-13 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.11.041
更新日期:2009-04-17 00:00:00
abstract:OBJECTIVES:We sought to evaluate the impact of final kissing balloon inflation (FKBI) after simple stent implantation for the treatment of non-left main true coronary bifurcation lesions in patients with acute coronary syndrome (ACS). BACKGROUND:Whether FKBI should be mandatory after simple stent implantation for the ...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2014-12-20 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:1995-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-06-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.02.072
更新日期:2018-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.07.098
更新日期:2014-09-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.12.115
更新日期:2009-04-17 00:00:00
abstract:BACKGROUND:Cardiovascular toxicity has become a challenging issue during cancer therapy. Nonetheless, there is a lack of consensual guidelines for their management. We aimed to determine the current practices of oncologists regarding cardiovascular toxicity related to anthracyclines, trastuzumab and angiogenic inhibito...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.154
更新日期:2017-08-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.02.039
更新日期:2014-05-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/0167-5273(95)02541-3
更新日期:1996-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.12.051
更新日期:2020-05-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90103-8
更新日期:1986-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.01.122
更新日期:2017-04-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.04.010
更新日期:2011-06-02 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.049
更新日期:2007-03-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2009-08-14 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1992-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 评论,历史文章,信件
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更新日期:2009-08-14 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2009-11-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2007.11.058
更新日期:2009-03-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.07.002
更新日期:2017-12-01 00:00:00
abstract::Clinical guidelines represent statements that seek to synthesize the best evidence to guide a course of action to improve health outcomes and more cost-effective use of resources. However, even when the evidence is not definitive, comprehensive documents are still needed to guide clinical decision-making. In these cir...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2015.06.059
更新日期:2015-11-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.10.029
更新日期:2019-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.077
更新日期:2009-07-24 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2012.05.008
更新日期:2013-09-01 00:00:00