Abstract:
PURPOSE:The aim of this study is to assess the association between peak oxygen uptake (VO2 peak), determined using a perceptually regulated 1-km walking test (1k-TWT), and all-cause mortality in cardiac patients. METHODS:1255 male patients, aged 25-85 years, completed a moderate 1k-TWT to estimate VO2 peak. Subjects were followed for all-cause mortality for up to 10 years. Cox proportional hazard models were employed to determine variables associated with mortality. Based on the estimated VO2 peak, the sample was subdivided into quartiles and mortality risks were calculated. To assess the discriminatory accuracy of the estimated VO2 peak for estimating survival, receiver-operating-characteristics curves were constructed. RESULTS:During a median 8.2 year follow-up, a total of 141 deaths from any cause occurred, yielding an average annual mortality of 1.4%. The strongest predictor of all-cause mortality was the estimated VO2 peak (c-statistic 0.71, 95% confidence intervals: 0.69-0.74, P<0.0001). Survival decreased in a graded fashion from the highest estimated VO2 peak quartile to the lowest quartile. Compared to the lowest quartile, the hazard ratios (95% confidence intervals) for the second, third, and fourth quartiles were 0.77 (0.35-1.33), 0.43 (0.20-0.91), and 0.16 (0.05-0.54) respectively (P for trend <0.0001). An 89% reduction in mortality risk was observed among a subset of subjects in the fittest quartile who improved their estimated VO2 peak over the follow-up period relative to subjects in the least fit quartile who did not improve. CONCLUSION:VO2 peak estimated by a novel 1k-TWT predicts survival in subjects with stable cardiovascular disease.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Grazzi G,Myers J,Bernardi E,Terranova F,Grossi G,Codecà L,Volpato S,Conconi F,Mazzoni G,Chiaranda Gdoi
10.1016/j.ijcard.2014.02.039subject
Has Abstractpub_date
2014-05-01 00:00:00pages
248-52issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(14)00394-5journal_volume
173pub_type
杂志文章abstract:BACKGROUND:Providing continuous follow-up care to patients with congenital heart disease (CHD) remains a challenge in many settings. Previous studies highlight that patients with CHD experience discontinuation of follow-up care, but mainly describe a single-centre perspective, neglecting inter-institutional variations....
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更新日期:2020-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:2012-07-26 00:00:00
abstract::In 29 patients with stable ischaemic heart disease, right heart catheterization was performed to assess the effect of exercise and nitroglycerin on right ventricular volumes, which were determined by a new computerized thermodilution system. The coefficient of variation for the determination of right ventricular eject...
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 传,历史文章,信件
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更新日期:2007-11-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/0167-5273(82)90002-x
更新日期:1982-01-01 00:00:00
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更新日期:1994-01-01 00:00:00
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journal_title:International journal of cardiology
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更新日期:2016-11-15 00:00:00
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更新日期:1996-05-01 00:00:00
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更新日期:2005-09-30 00:00:00
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pub_type: 杂志文章
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更新日期:2007-04-04 00:00:00
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更新日期:2021-01-15 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章
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