Abstract:
BACKGROUND:Isolated ventricular non-compaction (IVNC) is frequently, but not invariably, associated with left ventricular (LV) systolic dysfunction. Factors impacting on regional and global LV function are unknown. The aim of the study was to apply magnetic resonance imaging (MRI) to evaluate the impact of extent and severity of ventricular non-compaction on LV systolic function in patients with IVNC. METHODS:Sixteen adult patients with IVNC as defined by previously validated MRI criteria [ratio between end-diastolic thickness of non-compacted and compacted myocardium (NC/C ratio)> 2.3 in ≥ 1 LV segment] were enrolled. Short-axis cine images were employed for analysis. Applying a 16-segment LV model, regional systolic performance was assessed qualitatively (wall motion score, WMS; 1 = normal, 2 = mild hypokinesia, 3 = moderate-to-severe hypokinesia, and 4 = a/dyskinesia) as well as quantitatively [fractional wall thickening, FWT (%)=100 × (end-diastolic wall thickness-end-systolic wall thickness)/end-diastolic wall thickness)]. RESULTS:Mean LV ejection fraction was 43.8 ± 15.4% (range, 17-68%). Regional disease severity, as expressed by the NC/C ratio, revealed a significant correlation with WMS (r=0.26; p=0.018) and FWT (r=-0.30; p=0.006). The total number of non-compacted segments/patient (NoNC) as an index of disease extent was a significant independent correlate of LV ejection fraction by multivariate regression analysis (β=-5.24; p=0.038) and an excellent predictor of global LV dysfunction (ROC analysis, AUC=0.98; p<0.0001). CONCLUSIONS:In patients with IVNC, disease severity correlates with the degree of LV dysfunction at a regional level. The extent of myocardial non-compaction is an independent predictor of global LV dysfunction.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Dellegrottaglie S,Pedrotti P,Roghi A,Pedretti S,Chiariello M,Perrone-Filardi Pdoi
10.1016/j.ijcard.2011.01.063subject
Has Abstractpub_date
2012-07-26 00:00:00pages
394-9issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(11)00110-0journal_volume
158pub_type
临床试验,杂志文章abstract:BACKGROUND:Despite repair of aortic coarctation, hypertension is frequent in adults and premature coronary and cerebrovascular disease remain of concern. Persistent impairment of arterial dilation has been suspected to contribute to abnormal blood pressure regulation. We tested the hypothesis that arterial reactivity i...
journal_title:International journal of cardiology
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abstract::Fifteen patients with uncomplicated mild to moderate primary hypertension (7 males, 8 females, age range 36-65 years) were submitted to a double blind randomized crossover study, receiving MgO 3 times a day at a daily dose of 1.0 g (600 mg/day of magnesium) and placebo for a period of 6 weeks. This was to test the eff...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
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pub_type: 杂志文章,随机对照试验
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 社论
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pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of cardiology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of cardiology
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