Longitudinal necrotic shafts near TCFAs--a potential novel mechanism for plaque rupture to trigger ACS?

Abstract:

:It has been questioned for over 15 years why only less than 20% of TCFAs trigger ACS. We illustrate TCFA rupture into adjacent longitudinal necrotic shafts of massive amounts of thrombogenic material into the blood, leading to catastrophic clot formation. This is the potential mechanism for TCFAs triggering ACS. One case presented also illustrates the dangers of stent edges rupturing TCFAs.

journal_name

Int J Cardiol

authors

Brezinski ME,Harjai KJ

doi

10.1016/j.ijcard.2014.09.144

subject

Has Abstract

pub_date

2014-12-20 00:00:00

pages

738-41

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(14)01864-6

journal_volume

177

pub_type

社论
  • Clinical course and potential complications of small ventricular septal defects in adulthood: Late development of left ventricular dysfunction justifies lifelong care.

    abstract:BACKGROUND:Patients with small ventricular septal defects (VSDs) are thought to have excellent long-term survival, although complications may not be uncommon. METHODS:We identified all patients aged ≥ 16 years with native isolated VSD between January 2000 and September 2013. Clinical outcomes were retrospectively revi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.01.208

    authors: Karonis T,Scognamiglio G,Babu-Narayan SV,Montanaro C,Uebing A,Diller GP,Alonso-Gonzalez R,Swan L,Dimopoulos K,Gatzoulis MA,Li W

    更新日期:2016-04-01 00:00:00

  • Reversal of dilated cardiomyopathy after chronic tricyclic antidepressant drug withdrawal.

    abstract::Two patients referred for heart transplantation for dilated cardiomyopathy on chronic tricyclic antidepressant treatment are described. Echocardiographic normalization of left ventricular diameters and function were evidenced after drug withdrawal, suggesting drug-induced toxic myocardial disease. The possibility of f...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(94)02231-7

    authors: Martí V,Ballester M,Obrador D,Udina C,Moya C,Pons-Lladó G

    更新日期:1995-02-01 00:00:00

  • NADPH oxidase inhibitor apocynin prevents atrial remodeling in alloxan-induced diabetic rabbits.

    abstract:OBJECTIVES:Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). The role of the NADPH oxidase (NOX) signaling in the setting of DM and the potential benefits of apocynin on diabetic atrial remodeling remain unknown. METHODS:Sixty Japanese rabbits were randomized into 3 groups as follows: ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.07.132

    authors: Qiu J,Zhao J,Li J,Liang X,Yang Y,Zhang Z,Zhang X,Fu H,Korantzopoulos P,Liu T,Li G

    更新日期:2016-10-15 00:00:00

  • Role of right ventricular involvement in acute myocarditis, assessed by cardiac magnetic resonance.

    abstract:OBJECTIVES:Right ventricular (RV) myocarditis (MY) is unrecognized, and its prevalence is unknown. We evaluated the prevalence of RV involvement in acute MY and its association with cardiac events (cardiac death, cardiac arrest, ventricular assist device, transplantation, and appropriate ICD intervention). METHODS:We ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2018.04.087

    authors: Aquaro GD,Negri F,De Luca A,Todiere G,Bianco F,Barison A,Camastra G,Monti L,Dellegrottaglie S,Moro C,Lanzillo C,Scatteia A,Di Roma M,Pontone G,Perazzolo Marra M,Di Bella G,Donato R,Grigoratos C,Emdin M,Sinagra G

    更新日期:2018-11-15 00:00:00

  • Underestimation of duration of ventricular activation by 12-lead ECG compared with direct measurement of activation duration derived from implanted pacemaker leads.

    abstract:AIM:To determine extent to which 12-lead ECG QRS duration (QRSd) reflects ventricular activation duration compared with time relations from unpaced ventricular myograms in cardiac resynchronisation therapy (CRT) patients. METHODS:Left (LV) and right ventricular (RV) myograms were recorded during spontaneous rhythm fro...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ijcard.2010.07.001

    authors: Duncan AM,Lim E,Mebrate Y,Wong T,Gibson DG

    更新日期:2011-10-06 00:00:00

  • Malignant pheochromocytoma.

    abstract::We present an interesting case of paroxysmal hypertension in a young male caused by malignant pheochromocytoma. This patient, who had history of paroxysms of abdominal pain with severe hypertension, developed osseous metastasis in the first lumbar vertebra resulting in collapse of the vertebra and it caused paraplegia...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(92)90035-2

    authors: Pande AK

    更新日期:1992-03-01 00:00:00

  • Angioplasty of a left anterior descending artery originating from the right sinus of Valsalva (discussion in decision making).

    abstract::In this case report, we describe a successful percutaneous transluminal coronary angioplasty of an abnormally originating left anterior descending artery from the right sinus of Valsalva. We discuss about the decision making in this rare and challenging case, since there is more than one opinion as to which is the app...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(96)02730-1

    authors: Antonellis J,Kostopoulos K,Margaris N,Kranidis A,Patsilinakos S,Hitiris C,Salahas A,Tavernarakis A

    更新日期:1996-09-01 00:00:00

  • The placenta: A site of end-organ damage after Fontan operation. A case series.

    abstract:BACKGROUND:Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology. METHODS:We reviewed clinical charts and placental pathology from 7...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2019.02.002

    authors: Phillips AL,Cetta F,Kerr SE,Cheek EH,Rose CH,Bonnichsen CR,Phillips SD

    更新日期:2019-08-15 00:00:00

  • Predictors and clinical implications of stent thrombosis in patients with ST-segment elevation myocardial infarction: Insights from the EXAMINATION trial.

    abstract:BACKGROUND:Few data are available about safety of second generation drug eluting stents in an all-comer ST elevation myocardial infarction (STEMI) population. We sought to investigate the predictors and clinical implications of 1-year stent thrombosis (ST) in patients with STEMI, included in the EXAMINATION trial. MET...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ijcard.2013.03.036

    authors: Brugaletta S,Sabate M,Martin-Yuste V,Masotti M,Shiratori Y,Alvarez-Contreras L,Cequier A,Iñiguez A,Serra A,Hernandez-Antolin R,Mainar V,Valgimigli M,Tespili M,den Heijer P,Bethencourt A,Vazquez N,Gomez-Lara J,Backx B,

    更新日期:2013-10-03 00:00:00

  • Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine.

    abstract:BACKGROUND:Progressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac functi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2017.09.179

    authors: Choy JS,Leng S,Acevedo-Bolton G,Shaul S,Fu L,Guo X,Zhong L,Guccione JM,Kassab GS

    更新日期:2018-03-15 00:00:00

  • Electrocardiographic assessment of infarct size: comparison between QRS scoring of 12-lead electrocardiography and dynamic vectorcardiography.

    abstract::Myocardial infarct size is one of the most important predictors of prognosis in patients suffering an acute myocardial infarction. It can be assessed by enzymatic and electrocardiographic methods. The present report compares dynamic vectorcardiographic monitoring, serial plasma enzyme activity measurements and QRS sco...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0167-5273(93)90280-t

    authors: Dellborg M,Herlitz J,Risenfors M,Swedberg K

    更新日期:1993-07-01 00:00:00

  • Implications for single phase prospective CT coronary angiography for the diagnosis of significant coronary stenoses in clinical practice.

    abstract:BACKGROUND:CT coronary angiography (CTA) with 64 slice multi-detector CT (64-MDCT) has assumed an increasing role in clinical practice; however the high radiation dose associated with retrospective ECG-gated CTA has led to suggestions that a low dose prospectively gated strategy may be more appropriate. This study aims...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2009.09.542

    authors: Sá MI,Nicol ED,Stirrup J,Crean A,Roughton M,Padley SP,Rubens MB

    更新日期:2011-03-17 00:00:00

  • Transcriptional evaluation of relaxin and endothelin-1 axis in heart failure patients: First evidence of its involvement during left ventricular assist device support.

    abstract:BACKGROUND:Left ventricular assist devices (LVAD) are implanted in patients with end-stage heart failure (ESHF) as a mechanical support for the failing myocardium, which is characterized by an activation of the neuro-hormonal system, with release of vasoactive mediators, such as endothelin (ET)-1 and relaxin (RLX)-2. T...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2020.02.058

    authors: Cabiati M,Botta L,Caselli C,Del Ry S

    更新日期:2020-05-01 00:00:00

  • Phase differences between left ventricular wall motion and transmitral flow in man: evidence for involvement of ventricular restoring forces in normal rapid filling.

    abstract::To assess the possible role of restoring forces underlying left ventricular wall motion during rapid filling, the time relations between left ventricular dimensions and filling velocity were studied by digitised M-mode and Doppler echocardiography in 23 normal children and 43 patients: 11 with mild and 17 with severe ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(89)90014-4

    authors: Park CH,Chow WH,Gibson DG

    更新日期:1989-09-01 00:00:00

  • Methods of assessment of the post-exercise cardiac autonomic recovery: A methodological review.

    abstract::The analysis of post-exercise cardiac autonomic recovery is a practical clinical tool for the assessment of cardiovascular health. A reduced heart rate recovery - an indicator of autonomic dysfunction - has been found in a broad range of cardiovascular diseases and has been associated with increased risks of both card...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2016.10.057

    authors: Peçanha T,Bartels R,Brito LC,Paula-Ribeiro M,Oliveira RS,Goldberger JJ

    更新日期:2017-01-15 00:00:00

  • The appropriateness of percutaneous transluminal coronary angioplasty in Korea.

    abstract:BACKGROUND:The rapid adoption of percutaneous transluminal coronary angioplasty (PTCA) in Korea is provoking a widespread concern about possible overuse of this procedure with inappropriate indications. This study aimed to assess the rate of appropriate application of PTCA in Korea and investigate factors affecting thi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2003.03.028

    authors: Yim J,Khang YH,Oh BH,Kim YI,Kim CY

    更新日期:2004-06-01 00:00:00

  • Transient left ventricular apical ballooning: a novel heart syndrome.

    abstract::A novel cardiac syndrome of left ventricular apical ballooning (Takotsubo cardiomyopathy-ampulla cardiomyopathy) involves reversible left ventricular apical ballooning (during systole) of acute onset with chest pain, electrocardiographic changes, and minimal elevation of cardiac enzymes resembling acute myocardial inf...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2004.05.070

    authors: Korlakunta HL,Thambidorai SK,Denney SD,Khan IA

    更新日期:2005-07-10 00:00:00

  • Achieving contrast-free ultra-low radiation exposure without compromising safety and acute efficacy through evolving AF cryoballoon ablation procedure techniques.

    abstract:INTRODUCTION:In general, early experience with the first-generation cryoballoon introduced an increase in radiation exposure as compared to traditional radiofrequency ablations for atrial fibrillation (AF). However, through operator vigilance and the incorporation of various techniques and technologies, procedural radi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2019.06.018

    authors: Reiss J,O'Connell H,Getman MK

    更新日期:2020-01-15 00:00:00

  • Andersen-Tawil syndrome: clinical and molecular aspects.

    abstract::Andersen–Tawil syndrome (ATS) is a rare hereditary multisystem disorder. Ventricular arrhythmias, periodic paralysis and dysmorphic features constitute the classic triad of ATS symptoms. The expressivity of these symptoms is, however, extremely variable, even within single ATS affected families, and not all ATS patien...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2013.10.010

    authors: Nguyen HL,Pieper GH,Wilders R

    更新日期:2013-12-05 00:00:00

  • Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis.

    abstract:BACKGROUND:The effects of green tea intake on risk of cardiovascular disease (CVD) have not been well-defined. The aim of this meta-analysis was to evaluate the association between green tea consumption, CVD, and ischemic related diseases. METHODS:All observational studies and randomized trials that were published thr...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ijcard.2014.12.176

    authors: Pang J,Zhang Z,Zheng TZ,Bassig BA,Mao C,Liu X,Zhu Y,Shi K,Ge J,Yang YJ,Dejia-Huang,Bai M,Peng Y

    更新日期:2016-01-01 00:00:00

  • Patent foramen ovale with complex anatomy: Comparison of two different devices (Amplatzer Septal Occluder device and Amplatzer PFO Occluder device 30/35).

    abstract:BACKGROUND:Patent foramen ovale (PFO) closure after a cryptogenic cerebral ischemic event is a routinely procedure. The most used device is Amplatzer™ PFO Occluder 25 mm, but PFOs with complex anatomy require larger device for closure. We compared Amplatzer™ Septal Occluder (ASO) device versus Amplatzer™ PFO Occluder 3...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2018.10.053

    authors: Giordano M,Gaio G,Santoro G,Palladino MT,Sarubbi B,Golino P,Russo MG

    更新日期:2019-03-15 00:00:00

  • QT-interval variability in hypertrophic cardiomyopathy patients with cardiac arrest.

    abstract::We studied long-term variability of QT-dispersion in three patients with hypertrophic cardiomyopathy (Maron III) and ventricular fibrillation. Late potentials were absent on signal-averaged electrocardiogram. ST-segment depression was recorded in all three patients at Holter monitoring, and in two during exercise stre...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(94)90267-4

    authors: Miorelli M,Buja G,Melacini P,Fasoli G,Nava A

    更新日期:1994-06-15 00:00:00

  • Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.

    abstract:RATIONALE:Sirtuin (SIRT3), a major nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase in mitochondria, declines with aging and its ablation is associated with accelerated development of cardiovascular diseases. However, the role of SIRT3 in coronary microvascular function and post-MI recovery has not been...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.04.092

    authors: He X,Zeng H,Chen JX

    更新日期:2016-07-15 00:00:00

  • Comparison of the prognostic value of cardiopulmonary exercise testing between male and female patients with heart failure.

    abstract:BACKGROUND:Cardiopulmonary exercise testing (CPX) clearly holds prognostic value in the heart failure (HF) population. Studies investigating the prognostic value of CPX in individuals with HF have consistently examined predominantly male groups. The purpose of the present study was to examine the prognostic value of CP...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2005.11.105

    authors: Guazzi M,Arena R,Myers J

    更新日期:2006-11-18 00:00:00

  • Is anticoagulant therapy always indicated in "medium-risk" patients with first diagnosed atrial fibrillation? Insights from a real world, 10-year observational study.

    abstract:BACKGROUND:The choice of antithrombotic prophylaxis in the so-called "medium-risk" patients (i.e., CHA2DS2-VASc score = 1 in males or 2 in females) is one of the major enigmatic issues in clinical management of atrial fibrillation (AF). METHODS:We retrospectively evaluated 30-day and 1-year thromboembolic events in al...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2019.04.057

    authors: Bonfanti L,Lippi G,Donelli V,Pigna F,Saccenti C,Cervellin G

    更新日期:2019-08-01 00:00:00

  • Long-term prognosis after hospital admission for acute myocardial infarction from 1987 to 2006.

    abstract:BACKGROUND:Recent population-based estimates for long-term cardiovascular disease (CVD) mortality after hospitalization for a first acute myocardial infarction (AMI) are not well established. METHODS:Data from the Swedish hospital discharge and death registries were used to record all first-ever hospital admissions in...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2010.10.047

    authors: Dudas K,Lappas G,Rosengren A

    更新日期:2012-03-22 00:00:00

  • Impact of obesity on left ventricular systolic function in hypertensive subjects with normal ejection fraction.

    abstract::We sought to investigate the potential impact of obesity on left ventricular (LV) systolic function in patients with hypertension and normal ejection fraction (EF). In 112 hypertensive subjects with echocardiographic evidence of normal EF, M-mode left atrio-ventricular plane displacement, and Tissue Doppler-derived pe...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2008.11.129

    authors: Ballo P,Zacà V,Giacomin E,Galderisi M,Mondillo S

    更新日期:2010-06-11 00:00:00

  • Importance of the left ventricular outflow tract in the need for pacemaker implantation after transcatheter aortic valve replacement.

    abstract:BACKGROUND:The interaction of left ventricular outflow tract (LVOT) and transcatheter heart valve (THV) is complex and may be device design specific. We sought to study LVOT characteristics and its relation with permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR). METHODS:We stud...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.04.023

    authors: Rodríguez-Olivares R,van Gils L,El Faquir N,Rahhab Z,Di Martino LF,van Weenen S,de Vries J,Galema TW,Geleijnse ML,Budde RP,Boersma E,de Jaegere PP,Van Mieghem NM

    更新日期:2016-08-01 00:00:00

  • A cornerstone of heart failure treatment is not effective in experimental right ventricular failure.

    abstract:BACKGROUND:Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure tr...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2013.08.102

    authors: Borgdorff MA,Bartelds B,Dickinson MG,Steendijk P,Berger RM

    更新日期:2013-11-05 00:00:00

  • TGFβ1 contributes to cardiomyogenic-like differentiation of human bone marrow mesenchymal stem cells.

    abstract:BACKGROUND:The majority of the protocols for cardiomyocyte differentiation of MSC use 5-azacytidine as an inducer. As transforming growth factor β1 and 5-azacytidine share similar target signaling pathways, we examined whether transforming growth factor β1 can play a role in cardiac differentiation process in human mes...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2011.08.003

    authors: Mohanty S,Bose S,Jain KG,Bhargava B,Airan B

    更新日期:2013-02-10 00:00:00