Abstract:
:To assess the possible role of restoring forces underlying left ventricular wall motion during rapid filling, the time relations between left ventricular dimensions and filling velocity were studied by digitised M-mode and Doppler echocardiography in 23 normal children and 43 patients: 11 with mild and 17 with severe mitral regurgitation, and 15 with left ventricular hypertrophy due to aortic stenosis. In normal children, peak mitral flow velocity characteristically lagged peak rate of dimension increase by 50 +/- 15 msec, and peak rate of posterior wall thinning by 35 +/- 15 msec, (P less than 0.01 for both). Towards the apex, and along the long axis of the ventricle, these phase differences between dimension and flow velocity were not apparent. The characteristic time relations between flow velocity and transverse dimension were also present in patients with left ventricular hypertrophy or mild mitral regurgitation, but when mitral regurgitation was severe they were lost and there was no significant difference in timing between peak flow velocity and peak rate of dimension change (-2 +/- 30 msec) or wall thinning (-4 +/- 25 msec). We conclude that phase differences between left ventricular wall motion and mitral inflow velocity are present in the normal ventricles of children. They cannot be explained on the basis of simple shape changes or passive filling of the relaxing ventricle, but strongly suggest the additional presence of ventricular restoring forces. They persist in patients with left ventricular hypertrophy or mild mitral regurgitation, but are lost when the regurgitation is severe, the filling pattern reverting to that predicted for passive distension of the ventricular cavity by a high left atrial pressure.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Park CH,Chow WH,Gibson DGdoi
10.1016/0167-5273(89)90014-4subject
Has Abstractpub_date
1989-09-01 00:00:00pages
347-54issue
3eissn
0167-5273issn
1874-1754pii
0167-5273(89)90014-4journal_volume
24pub_type
杂志文章abstract::Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial myocardial fibrosis (DIF) or due to interstitial edema/inflammation. Concerns relating to nephrogenic systemic fibrosis with gadolinium-based contrast agents (GBCA) limit their use in end-stage kidney disease (ESKD)...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.06.007
更新日期:2019-10-15 00:00:00
abstract::Acute dissection of the ascending aorta may present with chest pain and haemopericardium. The following case illustrates an unusual differential diagnosis: rupture of a very large coronary artery aneurysm, diagnosed by transoesophageal echocardiography. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00086-2
更新日期:1998-06-01 00:00:00
abstract::We investigated the acute effect of transdermal estradiol-17-beta on exercise-induced ischemia in 15 postmenopausal women (mean age 58 +/- 6 years) with syndrome X (angina pectoris, positive exercise test and normal coronary angiogram) and eight healthy women (mean age 58 +/- 5 years) in a placebo-controlled, double-b...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(96)02560-0
更新日期:1996-04-19 00:00:00
abstract::A total of 664 high school students having >or=1 episode of syncope and 560 students without syncope (controls) underwent 12-lead ECG. A significant QT prolongation was defined as corrected QT (QTc)>470 ms in male and >480 ms in female. A diagnosis of LQTS was made by Schwartz's score. Most students had only 1 episode...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.07.102
更新日期:2009-01-24 00:00:00
abstract::With the changing demography of populations and increasing prevalence of co-morbidity, frail patients and more complex cardiac conditions, the modern medicine is facing novel challenges leading to rapid innovation where evidence and experiences are lacking. This scenario is also evident in cardiovascular disease preve...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2014.11.107
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Elevated plasma B-type natriuretic peptide (BNP) levels suggest a high risk for future onset of cardiovascular events including congestive heart failure (CHF) and mortality. In the general population, although median plasma BNP levels have been reported to be higher in women than in men, the incidence of CHF...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.01.076
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:White coat hypertension (WCH) is related to target organ damage and increased cardiovascular risk. Arterial elastic properties and urinary protein excretion are determinants of cardiovascular performance and predictors of outcomes. We investigated whether office blood pressure (BP) is a better determinant of...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.10.078
更新日期:2016-01-15 00:00:00
abstract::Myocardial ischaemia and reperfusion cause dysfunction of the coronary vasculature leading to a sustained reduction in coronary blood flow and an impairment of responses to both endothelium-dependent and endothelium-independent vasodilators. In contrast, when previously ischaemic arteries are removed from the myocardi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(97)00246-5
更新日期:1997-12-31 00:00:00
abstract:OBJECTIVE:In this paper we present an attempt at noninvasive imaging of distributed myocardial electrical activity in patients suffering from myocardial infarction and in healthy subjects. Although advances have been made, noninvasive three-dimensional imaging of cardiac electrophysiological activity is still in its in...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0167-5273(97)00326-4
更新日期:1998-03-13 00:00:00
abstract::Acquired left ventricular hypertrabeculation/noncompaction (LVHT) is rare and has been described in patients with mitochondriopathy, Barth syndrome, and Becker muscular dystrophy. Here we report acquired LVHT in a 28-year-old man with Duchenne muscular dystrophy who required non-invasive, positive-pressure ventilation...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.01.018
更新日期:2006-01-26 00:00:00
abstract:OBJECTIVES:Our objective was to investigate the actual incidence and clinical determinants of cough leading to discontinuation of ACE-inhibitors. Cough is the most frequent reason to stop ACE-inhibitor treatment. METHODS:We studied 27,492 ACE-inhibitor naïve patients randomized to the ACE-inhibitor perindopril or plac...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2014.07.108
更新日期:2014-10-20 00:00:00
abstract:OBJECTIVE:We investigated a full energetic profile of pressure and volume loaded right ventricle (RV) in porcine models by evaluating kinetic energy (KE), stroke power, power output and power loss across pulmonary valves with stenosis (PS) or with regurgitation (PR). METHODS:Fifteen pigs (6 PS and 6 PR, 3 unoperated c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.03.136
更新日期:2018-07-15 00:00:00
abstract::We analysed retrospectively the exercise electrocardiogram records of all patients with positive exercise tests which, on subsequent coronary angiography, proved to be "false positives". The exercise records of 10 "false positive" patients were compared with the records of 10 patients with true positive tests in the s...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90121-k
更新日期:1990-12-01 00:00:00
abstract:INTRODUCTION:Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation of the epicardial coronary arteries. We sought to determine whether isolated CAE may alter P-wave duration and dispersion (PD). METHODS:The study population consisted of 26 patients (mean age: 61.6+/-11.0 years) with isolated CAE ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.042
更新日期:2008-04-25 00:00:00
abstract:BACKGROUND:Dysregulation of dendritic cell (DC) mediated immune responses towards auto-antigens, is considered an important feature in the maintenance of experimentally induced heart failure (HF). In order to evaluate the role of blood DCs in cardiomyopathies of different origins, we examined myeloid (mDC) and plasmacy...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.10.031
更新日期:2009-01-09 00:00:00
abstract:BACKGROUND:Isolated ventricular non-compaction (IVNC) is frequently, but not invariably, associated with left ventricular (LV) systolic dysfunction. Factors impacting on regional and global LV function are unknown. The aim of the study was to apply magnetic resonance imaging (MRI) to evaluate the impact of extent and s...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2011.01.063
更新日期:2012-07-26 00:00:00
abstract:BACKGROUND:Despite several case reports of sirolimus-eluting stent (SES) fracture and concern regarding restenosis after successful SES implantation, the clinical characteristics of this problem are not well known. METHODS:Clinical records and angiographic films of patients who received follow-up coronary angiography ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.10.059
更新日期:2009-01-09 00:00:00
abstract::Congenital coronary sinus anomalies are unusual and they rarely coexist with accessory atrioventricular pathways. These anomalies are generally asymptomatic, however they can cause difficulty in mapping. The association between accessory pathway and coronary sinus anomalies may suggest an embryologic link. In this cas...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/S0167-5273(03)00152-9
更新日期:2004-02-01 00:00:00
abstract::ACEI and AT1 receptor antagonists are the drugs most consistently shown to reduce ADMA level in humans. Unfortunately, most of the human studies addressing the effect of pharmacotherapy on ADMA metabolism were accomplished on small patient subgroups and were relatively shortlasting. Besides, L-arginine was rarely meas...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.109
更新日期:2010-06-25 00:00:00
abstract:BACKGROUND:Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHOD...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.02.072
更新日期:2018-08-01 00:00:00
abstract:AIMS:To conduct a prospective, individual participant data (IPD) meta-analysis of randomised controlled trials comparing a polypill-based approach with usual care in high risk individuals. METHODS AND RESULTS:Three trials comparing polypill-based care with usual care in individuals with CVD or high calculated cardiova...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.12.015
更新日期:2016-02-15 00:00:00
abstract:AIMS:Vascular smooth muscle cell (VSMC) migration, proliferation and remodeling of the extracellular matrix contribute to lumen loss after arterial injury leading to restenosis. Several studies indicated the role of the cyclic guanosine monophosphate signaling in neointimal formation. Cinaciguat, the novel soluble guan...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.01.032
更新日期:2013-07-31 00:00:00
abstract:OBJECTIVES:The Seven Countries Study showed that fatal coronary heart disease (CHD) with only chronic heart failure, arrhythmia or blocks (atypical CHD, A-CHD) may represent a distinct disease as compared to fatal CHD cases with angina pectoris, acute myocardial infarction (AMI) or sudden death (typical CHD, T-CHD). We...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.021
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:The present meta-analysis aimed to compare the diagnostic accuracy of more recent computed tomography coronary angiography (CTCA) with invasive coronary angiography (ICA) in the assessment of graft patency after coronary artery bypass graft surgery (CABG). MATERIAL AND METHODS:A systematic review was performed...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2016.06.264
更新日期:2016-10-15 00:00:00
abstract:BACKGROUND:Direct oral anticoagulants (DOACs) have emerged as the preferred choice of oral anticoagulation in patients with atrial fibrillation. Randomized trials have demonstrated the efficacy and safety of DOAC in patients undergoing electrical cardioversion (ECV); however, there is limited real-world data. OBJECTIV...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.10.070
更新日期:2020-11-02 00:00:00
abstract::Swyer-James (MacLeod's) syndrome is a rare entity that is characterized by the hyperlucent appearance of one or more lobes of one lung, diminished ipsilateral hilar shadow and hardly visible arterial structure on chest radiography. Ventricular septal defect is the most common childhood congenital heart defect and, if ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.04.042
更新日期:2006-10-26 00:00:00
abstract:BACKGROUND:Cardiac myxomas (CMs) are a major primary heart tumor which often causes unexpected symptoms or sudden death. Among CMs, biatrial myxomas are even rare. This study was designed to investigate the clinical characteristics and surgical treatment of 5 cases with biatrial myxoma, to summarize the treatment exper...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.171
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Recent evidence indicates that epicardial adipose tissue (EAT) expresses uncoupling protein-1 (UCP1), a marker of brown adipocytes. However, the putative effects of the presence of brown adipocytes in EAT remain unknown. METHODS:The mRNA expression of genes related to brown adipocyte-mediated thermogenesis ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.06.008
更新日期:2013-09-01 00:00:00
abstract::The negative inotropism, myocardial dilatation and cytotoxicity in inflammatory heart disorders may be due to increased generation of nitric oxide (NO) by immunological induction of a high output NO pathway. This short review discusses the initial experiments which lead to this hypothesis, and evaluates data that this...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/0167-5273(95)02386-b
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Several intervention studies have investigated the relation between potassium intake and blood-pressure, particularly in hypertensive subjects. However, uncertainties still exist about the existence and the amount of such an effect, and about the role of some potential effect-modifiers, including the baselin...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2016.12.048
更新日期:2017-03-01 00:00:00