Abstract:
BACKGROUND:Dysregulation of dendritic cell (DC) mediated immune responses towards auto-antigens, is considered an important feature in the maintenance of experimentally induced heart failure (HF). In order to evaluate the role of blood DCs in cardiomyopathies of different origins, we examined myeloid (mDC) and plasmacytoid (pDC) subset levels and maturation characteristics, according to HF severity and etiology in humans. METHODS:Absolute numbers of mDCs and pDCs in 12 New York Heart Association (NYHA) class-II, 28 NYHA class III-IV HF patients and 18 healthy controls, were studied by 4-colour whole blood flow cytometry. RESULTS:End-stage (NYHA III-IV) HF patients had comparable circulating DC subset levels to NYHA-II patients and controls. However, within the NYHA III-IV group total DC levels in patients with non-ischemic dilated cardiomyopathy (DCM) were higher (P<0.001) than in patients with coronary artery disease (CAD), hypertrophic cardiomyopathy (HCM) or other HF etiology. This was due to a significant increase of primarily mDCs (P<0.0001) and to a lesser extent of pDCs (P<0.05) in idiopathic DCM patients, independent of systolic or diastolic cardiac dysfunction. Maturation marker CD83 and lymphoid homing chemokine receptor CCR7 surface expression was enhanced only on mDCs, but not pDCs from DCM patients (P<0.05), compared to patients with CAD, HCM or other underlying cardiac pathophysiology. CONCLUSIONS:Total blood DC levels in end-stage HF are elevated in patients with DCM. Whole blood DC characterisation may lead to new insights into the pathophysiology of idiopathic DCM in humans.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Athanassopoulos P,Balk AH,Vaessen LM,Caliskan K,Takkenberg JJ,Weimar W,Bogers AJdoi
10.1016/j.ijcard.2007.10.031subject
Has Abstractpub_date
2009-01-09 00:00:00pages
246-56issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(07)01964-Xjournal_volume
131pub_type
杂志文章abstract:BACKGROUND:Doxorubicin (DOXO) is an effective anti-neoplastic drug but its clinical benefits are hampered by cardiotoxicity. Oxidative stress, apoptosis and myocardial fibrosis mediate the anthracycline cardiomyopathy. ROS trigger TGF-β pathway that activates cardiac fibroblasts promoting fibrosis. Myocardial stiffness...
journal_title:International journal of cardiology
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更新日期:2016-02-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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abstract:BACKGROUND:Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHOD...
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abstract:BACKGROUND:This study aimed to evaluate real-world clinical outcome of patients needing short dual antiplatelet therapy (S-DAPT) following PCI with Ultimaster® thin-strut, biodegradable polymer sirolimus-eluting stent (BP-SES), which was supposed to induce faster stent endothelialization and reduce device thrombogenici...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND:Patients with small ventricular septal defects (VSDs) are thought to have excellent long-term survival, although complications may not be uncommon. METHODS:We identified all patients aged ≥ 16 years with native isolated VSD between January 2000 and September 2013. Clinical outcomes were retrospectively revi...
journal_title:International journal of cardiology
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abstract::Coronary arterial disease in the cardiac allograft has emerged as the most serious long term complication of cardiac transplantation. The influence of patient-related and other potential risk factors on the development of coronary arterial disease at 1 year subsequent to cardiac transplantation was examined in 207 rec...
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.03.151
更新日期:2017-09-15 00:00:00
abstract:BACKGROUND:Inflammation is a major contributor to atherosclerotic vascular disease. Inflammatory parameters such as C-reactive protein (CRP) and Interleukin-6 (IL-6) have been shown to be strong predictors of cardiovascular events. The association between preoperative inflammatory parameters and early graft occlusion a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.09.004
更新日期:2007-08-09 00:00:00
abstract:OBJECTIVE:Determining the adherence to ACC/AHA/ESC 2006 guidelines and its influence on the survival of patients with atrial fibrillation. METHODS:Prospective observational study of patients discharged during 2007 from an Internal Medicine department with a main or secondary diagnose of atrial fibrillation. The stroke...
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pub_type: 杂志文章
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更新日期:2014-09-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.03.020
更新日期:2018-06-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2013.01.224
更新日期:2013-10-03 00:00:00
abstract::We examined serial changes in serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) measured by ELISAs in 45 patients with acute myocardial infarction (AMI) who received heparin intravenously for 3 to 5 days after the onset and in 30 control subjects with an old myocardial...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00251-4
更新日期:1998-11-30 00:00:00
abstract::Over a period of 12 years, two cases of pulmonary arterial aneurysms were encountered in our autopsy data of 13 cases of congenital heart defects with right-sided infective endocarditis. Pulmonary arterial aneurysms are rare lesions and may be categorized as central or peripheral. Although early reports implicated tub...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90247-z
更新日期:1992-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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pub_type: 信件
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更新日期:2009-03-06 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.194
更新日期:2008-02-20 00:00:00
abstract:BACKGROUND:Chagas' cardiomyopathy (CC) is a rising etiology for heart failure (HF) that previously was restricted to some countries of Latin America. The chronic CC cases cause now a profound socio-economic impact. However this issue has not been well studied if compared to other causes of HF. The objective of this stu...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.01.262
更新日期:2013-10-03 00:00:00
abstract::Patients with dyslipidemia are at increased risk of coronary heart disease (CHD), while treatment to reduce low density lipoprotein cholesterol (LDL-C) concentrations lessens this risk. Consequently, the Lipid Treatment Assessment Project (L-TAP) was undertaken in the US to determine the extent to which primary care p...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2000-06-30 00:00:00
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pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.12.026
更新日期:2015-02-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2010-08-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2009-04-03 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-03-20 00:00:00
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更新日期:2003-12-01 00:00:00