Abstract:
BACKGROUND:Skeletal muscle atrophy and decreased expression of slow fibers contribute to exercise capacity limitation in Chronic Heart Failure (CHF). Pro-inflammatory cytokines and free radicals worsen muscle damage. In CHF sarcomeric proteins are oxidized with reduction of muscle twitch efficiency, and VO(2)-max. Beta-blockers with anti-oxidative capacity such as carvedilol have been shown to prevent contractile protein oxidation in CHF rats. Recently a new class of beta-blockers with NO donor activity has been introduced and approved for the treatment of CHF. Since a clinical clear superiority of a beta-blocker has never been shown, we compared nebivolol, that possesses NO donor activity, with bisoprolol, looking at possible differences in skeletal muscle that may have an impact on muscle function and exercise capacity in humans. We therefore studied skeletal muscle apoptosis and wastage, sarcomeric protein composition and oxidation, and muscle efficiency. METHODS AND RESULTS:In the monocrotaline rat model of CHF we compared nebivolol a beta-blocker with vasodilative properties mediated by NO production, with bisoprolol. Nebivolol prevented protein oxidation, while bisoprolol did it only partially, as demonstrated by the oxyblot analysis (Oxy/RP values) (0.90+/-0.14 Controls.; 1.7+/-0.14 CHF; 1.1+/-0.05 bisoprolol; 0.82+/-0.17 nebivolol low; 0.62+/-0.10 nebivolol high). Only nebivolol improved twitch force production and relaxation. Nebivolol prevented fibers shift towards fast isoforms, atrophy, decreased apoptosis and sphingosine levels. CONCLUSIONS:Nebivolol seems better than bisoprolol in CHF by decreasing apoptosis and cytokines induced muscle wastage, preventing fibers shift and protein oxidation. Nebivolol by stimulating NO generation may have prevented protein oxidation. It could be speculated that ROS release, pro-inflammatory cytokines production and NF-kappa-B activation may play a key role. These positive changes could produce a favorable impact on exercise capacity in man.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Dalla Libera L,Ravara B,Gobbo V,Betto DD,Germinario E,Angelini A,Evangelista S,Vescovo Gdoi
10.1016/j.ijcard.2009.02.012subject
Has Abstractpub_date
2010-08-20 00:00:00pages
192-9issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(09)00177-6journal_volume
143pub_type
杂志文章abstract:BACKGROUND:Myocardial CCN2/CTGF (connective tissue growth factor) is strongly induced in heart failure (HF) and acts as a cardioprotective factor in ischemia/reperfusion injury. However, its functional role in myocardial hypertrophy remains unresolved. METHODS AND RESULTS:Transgenic mice with cardiac-restricted overex...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-10-03 00:00:00
abstract:BACKGROUND:Definition of ischemic cardiomyopathy (IC) is not always obvious, which is why new criteria based on prognosis and the extent of the coronary artery disease (CAD) have been proposed. In the present study, we assess the capability of late gadolinium-enhanced cardiovascular magnetic resonance (CMR) for predict...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.040
更新日期:2007-03-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.07.066
更新日期:2014-09-01 00:00:00
abstract::The analysis of post-exercise cardiac autonomic recovery is a practical clinical tool for the assessment of cardiovascular health. A reduced heart rate recovery - an indicator of autonomic dysfunction - has been found in a broad range of cardiovascular diseases and has been associated with increased risks of both card...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2017-01-15 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/s0167-5273(03)00102-5
更新日期:2003-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2009-04-17 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-11-15 00:00:00
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.03.049
更新日期:2009-01-24 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2012.04.041
更新日期:2013-08-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2009.05.044
更新日期:2010-11-05 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-04-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-03-02 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-01-15 00:00:00
abstract:BACKGROUND:Oral anticoagulant therapy is central to the prevention thromboembolic events in atrial fibrillation (AF) patients. The SAMe-TT2R2 score is a simple clinical-derived score designed to aid decision-making on whether or not a patient is likely to achieve good anticoagulation control on vitamin K Antagonists (V...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.05.080
更新日期:2015-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2008.08.023
更新日期:2010-02-18 00:00:00
abstract::A 25-year-old man with massive pericardial effusion is presented. The high lymphocyte amount and cytological analysis of the aspirated fluid suggested tuberculous or malignant pericarditis. The chylous nature of the effusion was only recognized after hemipericardiectomy, when reaccumulation of fluid into the pleural s...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90186-0
更新日期:1987-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.060
更新日期:2007-06-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90066-c
更新日期:1992-04-01 00:00:00
abstract::In the nineties, the present author developed a didactic endothelium dysfunction classification based on personal experience while waiting for a consensus about the need of such an accomplishment. As time went by and no publications regarding this subject were released, he published a text entitled "An open discussion...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.05.031
更新日期:2009-10-02 00:00:00