当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Relation of the SAMe-TT2R2 score to quality of anticoagulation control and thromboembolic events in atrial fibrillation patients: Observations from the SPORTIF trials.

Relation of the SAMe-TT2R2 score to quality of anticoagulation control and thromboembolic events in atrial fibrillation patients: Observations from the SPORTIF trials.

Abstract：

BACKGROUND:Oral anticoagulant therapy is central to the prevention thromboembolic events in atrial fibrillation (AF) patients. The SAMe-TT2R2 score is a simple clinical-derived score designed to aid decision-making on whether or not a patient is likely to achieve good anticoagulation control on vitamin K Antagonists (VKA, e.g. warfarin). Good anticoagulation control is associated with optimal VKA efficacy and safety. METHODS:The SAMe-TT2R2 score was studied in a large cohort of warfarin-treated non-valvular AF patients from the SPORTIF trials, and related to time in therapeutic range (TTR) as measure of anticoagulation control, and thromboembolism-related outcomes. RESULTS:Among the 3665 patients originally assigned to the warfarin arm, a SAMe-TT2R2 score>2 was found in 19.5%. In these patients, a linear relationship was reported between SAMe-TT2R2 score and TTR (p<0.001). SAMe-TT2R2>2 was inversely associated with a higher proportion with TTR >65% (p=0.014) or TTR >70% (p=0.011). Patients with SAMe-TT2R2 score>2 had a significantly higher event rate of the composite thromboembolism-related outcome, vs. SAMe-TT2R2 0-2 (10.2% vs. 7.9%, p=0.045). On survival analysis, SAMe-TT2R2>2 was associated with a higher risk for the composite outcome (Log-Rank: 5.471, p=0.019). On Cox regression, a SAMe-TT2R2 score>2 was independently associated with the composite outcome (p=0.020). CONCLUSIONS:In this large trial cohort of AF patients, the SAMe-TT2R2 score was able to identify patients more likely to obtain suboptimal anticoagulation control on VKA, with an increase in major thromboembolism-related adverse events consequent upon such poor anticoagulation control.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Proietti M,Lane DA,Lip GY

doi

10.1016/j.ijcard.2016.04.131

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

168-72

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)30830-0

journal_volume

216

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Role of stem cell homing in myocardial regeneration.

    abstract：:Recent studies have demonstrated the potential for myocardial regeneration at the time of myocardial infarction. Our lab focuses on understanding how stem cells home to injured tissue. We believe that a detailed analysis of the biological responses to tissue injury not only gives us insight into how damage occurs, but...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(04)90007-1

    authors： Penn MS,Zhang M,Deglurkar I,Topol EJ

    更新日期：2004-06-01 00:00:00

  • Aortic and mitral discontinuity with congenital subaortic aneurysm and normally connected great arteries: echocardiographic diagnosis in life.

    abstract：:A newborn with preductal coarctation and ventricular septal defect had a subaortic aneurysm which protruded into the left atrium causing intractable pulmonary oedema. The subaortic aneurysm was congenital. It was clearly identified by cross-sectional echocardiography which, in serial studies, showed it to be increasin...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(87)90183-5

    authors： Andrade JL,de Leval M,Somerville J

    更新日期：1987-01-01 00:00:00

  • Left ventricular shape and function in primary coronary angioplasty.

    abstract：OBJECTIVES:To evaluate the effects of primary coronary angioplasty (PCA) on regional left ventricular (LV) contractile dysfunction and deformation, and on global remodeling. METHODS:In 99 consecutive patients (81 males, aged 61+/-11 years) who underwent successful PCA of left anterior descending (LAD) and right corona...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2007.03.113

    authors： Barletta G,Antoniucci D,Buonamici P,Toso A,Del Bene R,Fantini F

    更新日期：2008-04-25 00:00:00

  • A meta-analysis of randomized controlled trials of uninterrupted periprocedural anticoagulation strategy in patients undergoing atrial fibrillation catheter ablation.

    abstract：BACKGROUND:In patients undergoing atrial fibrillation (AF) ablation, despite uninterrupted oral anticoagulants (OACs) have been recommended, no consensus has emerged regarding to whether uninterrupted novel oral anticoagulants (NOACs) are superior to uninterrupted vitamin K antagonists (VKAs) for the periprocedural ant...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2018.06.024

    authors： Zhao Y,Lu Y,Qin Y

    更新日期：2018-11-01 00:00:00

  • Right atrial function in patients with pulmonary hypertension: A study with two-dimensional speckle-tracking echocardiography.

    abstract：BACKGROUND:The role of right atrial (RA) dysfunction in patients with pulmonary hypertension (PH), as evaluated by two-dimensional speckle-tracking echocardiography (2D-STE) remains to be determined. METHODS:Sixty consecutive PH patients and 30 healthy volunteers were included. RA function was evaluated by 2D-STE, and...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.11.093

    authors： Meng X,Li Y,Li H,Wang Y,Zhu W,Lu X

    更新日期：2018-03-15 00:00:00

  • Management of non-ST-elevation acute coronary syndromes: how cost-effective are glycoprotein IIb/IIIA antagonists in the UK National Health Service?

    abstract：BACKGROUND:The glycoprotein IIb/IIIa antagonists (GPAs) represent a new class of drugs to prevent platelet aggregation in the acute treatment of non-ST-elevation acute coronary syndromes (NSTE-ACS). Systematic reviews have identified serious limitations in published cost-effectiveness analyses, including a lack of UK-s...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2004.08.042

    authors： Palmer S,Sculpher M,Philips Z,Robinson M,Ginnelly L,Bakhai A,Abrams K,Cooper N,Packham C,Alfakih K,Hall A,Gray D

    更新日期：2005-04-20 00:00:00

  • Andersen-Tawil syndrome: clinical and molecular aspects.

    abstract：:Andersen–Tawil syndrome (ATS) is a rare hereditary multisystem disorder. Ventricular arrhythmias, periodic paralysis and dysmorphic features constitute the classic triad of ATS symptoms. The expressivity of these symptoms is, however, extremely variable, even within single ATS affected families, and not all ATS patien...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2013.10.010

    authors： Nguyen HL,Pieper GH,Wilders R

    更新日期：2013-12-05 00:00:00

  • Clinical profile of concealed form of arrhythmogenic right ventricular cardiomyopathy presenting with apparently idiopathic ventricular arrhythmias.

    abstract：:In 24 subjects presenting with apparently idiopathic ventricular arrhythmias, a final diagnosis of arrhythmogenic right ventricular cardiomyopathy was formulated following global evaluation of the clinical, cross-sectional echocardiography and angiographic findings, and the observation of myocardial atrophy with fibro...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(92)90177-5

    authors： Nava A,Thiene G,Canciani B,Martini B,Daliento L,Buja G,Fasoli G

    更新日期：1992-05-01 00:00:00

  • The relationship of marked left axis deviation to the risk of ischemic heart disease.

    abstract：:The purpose of this study was to examine the value of marked left axis deviation in men without apparent heart disease in the assessment of ischemic heart disease risk. In the Manitoba Study, a cohort of 3983 men who were predominantly between 25 to 34 yr of age at entry in 1948, 247 cases of marked left axis deviatio...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(81)90030-9

    authors： Rabkin SW,Mathewson FA,Tate RB

    更新日期：1981-01-01 00:00:00

  • The role of red blood cells in the progression and instability of atherosclerotic plaque.

    abstract：:This review attempts to present a focused summary of selected areas of the rapidly growing knowledge regarding the red blood cells role in atherosclerotic plaque progression and instability. A summary of the characteristics of the erythrocyte membranes is provided, followed by a brief review of the in vitro and in viv...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2009.10.031

    authors： Tziakas DN,Chalikias GK,Stakos D,Boudoulas H

    更新日期：2010-06-25 00:00:00

  • Skeletal muscle proteins oxidation in chronic right heart failure in rats: can different beta-blockers prevent it to the same degree?

    abstract：BACKGROUND:Skeletal muscle atrophy and decreased expression of slow fibers contribute to exercise capacity limitation in Chronic Heart Failure (CHF). Pro-inflammatory cytokines and free radicals worsen muscle damage. In CHF sarcomeric proteins are oxidized with reduction of muscle twitch efficiency, and VO(2)-max. Beta...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.02.012

    authors： Dalla Libera L,Ravara B,Gobbo V,Betto DD,Germinario E,Angelini A,Evangelista S,Vescovo G

    更新日期：2010-08-20 00:00:00

  • Impact of routine manual aspiration thrombectomy on outcomes of patients undergoing primary percutaneous coronary intervention for acute myocardial infarction: A meta-analysis.

    abstract：BACKGROUND:The efficacy and safety of thrombectomy as an adjunct to primary percutaneous intervention (PCI) in the management of acute myocardial infarction (AMI) are debated. We performed a meta-analysis of randomized trials comparing primary PCI performed with versus without routine aspiration thrombectomy (AT). MET...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2015.11.135

    authors： Barkagan M,Steinvil A,Berchenko Y,Finkelstein A,Keren G,Banai S,Halkin A

    更新日期：2016-02-01 00:00:00

  • ST-segment changes after direct current external cardioversion for atrial fibrillation. Incidence, characteristics and predictive factors.

    abstract：BACKGROUND:Incidence, characteristics and predictive factors of transient ST-segment changes after DC shock are poorly known. METHODS:91 consecutive pts referred for external cardioversion of atrial fibrillation (AF) (61 men, 69±10 yo) were prospectively included. The presence of ST elevation or depression was assesse...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.11.031

    authors： Rumeau P,Fourcade J,Duparc A,Hébrard A,Mondoly P,Rollin A,Massabuau P,Detis N,Elbaz M,Carrié D,Galinier M,Delay M,Maury P

    更新日期：2011-05-05 00:00:00

  • Angiotensin receptor-neprilysin inhibitors: A new paradigm in heart failure with reduced ejection fraction.

    abstract：:Despite significant advances in the last 30 years in reducing morbidity and mortality from heart failure with reduced ejection fraction (HFrEF) with pharmacological and device-based therapies, patients remain at a high risk of adverse cardiovascular outcomes. Sacubitril/valsartan, a first-in-class angiotensin receptor...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2018.05.124

    authors： Docherty KF,McMurray JJV

    更新日期：2019-04-15 00:00:00

  • The association between the HLA antigens and Takayasu's arteritis in Thai patients.

    abstract：:The HLA-A, -B, -DR and -DQ antigen distribution in 20 unrelated Thai patients with Takayasu's arteritis was compared with that in 44 healthy controls. The frequency of HLA-A31 and HLA-B52 (chi2=4.54, P<0.05; chi2=3.80, P<0.05, RR=7.5) appeared to be increased in the patient group. In contrast, the frequency of HLA-A24...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(98)00158-2

    authors： Charoenwongse P,Kangwanshiratada O,Boonnam R,Hoomsindhu U

    更新日期：1998-10-01 00:00:00

  • Is direct method of low density lipoprotein cholesterol measurement appropriate for targeting lipid lowering therapy?

    abstract：OBJECTIVES:The aim of this study was to compare the Friedewald Formula with direct homogeneous low density lipoprotein cholesterol (LDL-C) assay for the detection of LDL-C levels. METHODS:Fasting serum samples were obtained for lipid analysis from 1001 patients. Total cholesterol (TC) and triglyceride (TG) levels were...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2008.11.141

    authors： Can M,Acikgoz S,Mungan G,Ugurbas E,Ankarali H,Sumbuloglu V,Demirtas S,Karaca L

    更新日期：2010-06-25 00:00:00

  • Non-invasive determination of cardiac output: comparison of a novel CW Doppler ultrasonic technique and inert gas rebreathing.

    abstract：BACKGROUND:Cardiac Output (CO) is an important parameter in the diagnosis and therapy of heart diseases. Inert gas rebreathing (IGR) and continuous wave Doppler ultrasound (CWD) are among the most promising newer techniques aiming at a non-invasive, point of care measurement of CO. A direct comparison of the two method...

    journal_title：International journal of cardiology

    pub_type： 临床试验,信件

    doi：10.1016/j.ijcard.2008.04.057

    authors： Saur J,Trinkmann F,Weissmann J,Borggrefe M,Kaden JJ

    更新日期：2009-08-14 00:00:00

  • A case of splenic artery aneurysm with Cushing's syndrome.

    abstract：:We report here a case of splenic artery aneurysm with Cushing's syndrome. Pregnancy and the increased secretion of cortisol from an adrenal adenoma in Cushing's syndrome may affect the intimal and medial degeneration. Factors other than glucocorticoids may influence the pathological changes. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0167-5273(96)02608-3

    authors： Yoshitomi Y,Yoshimi H,Yutani C

    更新日期：1996-06-01 00:00:00

  • Spatial relationship of sites for atrial fibrillation drivers and atrial tachycardia in patients with both arrhythmias.

    abstract：INTRODUCTION:Atrial fibrillation (AF) often converts to and from atrial tachycardia (AT), but it is undefined if these rhythms are mechanistically related in such patients. We tested the hypothesis that critical sites for AT may be related to regional AF sources in patients with both rhythms, by mapping their locations...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2017.07.003

    authors： Baykaner T,Zaman JAB,Rogers AJ,Navara R,AlHusseini M,Borne RT,Park S,Wang PJ,Krummen DE,Sauer WH,Narayan SM

    更新日期：2017-12-01 00:00:00

  • Recurrent pulmonary embolism with non-mobile thrombus in a patient with leiomyosarcoma of the left renal vein.

    abstract：:We describe the case of a man who suffered recurrent pulmonary embolisms despite well-conducted oral anticoagulant therapy. Echocardiography and helical computed tomography revealed a non-mobile right atrial mass related to a leiomyosarcoma of the left renal vein. The prognosis of such a disease is bad and the patient...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2005.07.044

    authors： Mansencal N,El Hajjam M,Vieillard-Baron A,Pelage JP,Lacombe P,Dubourg O

    更新日期：2006-09-20 00:00:00

  • Successful management of osteal perforation of left anterior descending artery with coated stent.

    abstract：:Coronary perforation is a rare complication of percutaneous coronary intervention. We report a case of left anterior descending artery osteal perforation that led to acute cardiac tamponade during excimer laser angioplasty. Perforation was successfully covered with a PTFE-coated stent with preserved distal coronary fl...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/s0167-5273(02)00382-0

    authors： Yilmaz H,Demir I,Sancaktar O,Basarici I

    更新日期：2003-04-01 00:00:00

  • Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J mice.

    abstract：BACKGROUND:Cardiac myosin heavy chain-α (Myhc), an intracellular protein expressed in the cardiomyocytes, has been identified as a major autoantigen in cardiac autoimmunity. In our studies with Myhc334-352-induced experimental autoimmune myocarditis in A/J mice (H-2a), we discovered that Myhc334-352, supposedly a CD4 T...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.09.016

    authors： Massilamany C,Gangaplara A,Basavalingappa RH,Rajasekaran RA,Khalilzad-Sharghi V,Han Z,Othman S,Steffen D,Reddy J

    更新日期：2016-01-01 00:00:00

  • Vessel dilator is associated with survival after acute myocardial infarction.

    abstract：:To assess whether infarct size, ischemic area and/or survival correlates with circulating atrial natriuretic peptides (long acting sodium stimulator, vessel dilator, or atrial natriuretic factor), these peptides were measured in a canine model of acute myocardial infarction. Elevations in the circulating concentration...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)02192-l

    authors： Ackerman BH,Wyeth RP,Soulsby ME,Pappas AA,Vesely DL

    更新日期：1995-01-06 00:00:00

  • A wearable remote monitoring system for the identification of subjects with a prolonged QT interval or at risk for drug-induced long QT syndrome.

    abstract：BACKGROUND:A correct measurement of the QT interval in the out-of-hospital setting is important whenever the long QT syndrome (LQTS) is suspected or a therapy might lead to drug-induced LQTS (diLQTS) because QT interval monitoring in the initial days of therapy could alert to dangerous QT prolongation. We explored whet...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.03.097

    authors： Castelletti S,Dagradi F,Goulene K,Danza AI,Baldi E,Stramba-Badiale M,Schwartz PJ

    更新日期：2018-09-01 00:00:00

  • Lipid profiles and endothelial function with low-dose hormone replacement therapy in postmenopausal women at risk for coronary artery disease: a randomized trial.

    abstract：AIMS:To compare the effect of low (0.3 mg) and commonly prescribed (0.625 mg) doses of conjugated equine estrogens (CEE) on brachial artery flow-mediated dilation and lipid profiles. METHODS AND RESULTS:Twenty-five postmenopausal women (mean age, 65+/-6 years) at risk for coronary artery disease (CAD) (> or =2 establi...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0167-5273(02)00505-3

    authors： Mercuro G,Vitale C,Fini M,Zoncu S,Leonardo F,Rosano GM

    更新日期：2003-06-01 00:00:00

  • Early detection of biventricular involvement in myotonic dystrophy by tissue Doppler.

    abstract：BACKGROUND:Myotonic dystrophy is associated with arrhythmias and risk of sudden death but also with symptoms of heart failure. Our study aimed to identify early biventricular dysfunction in asymptomatic patients with myotonic dystrophy by tissue Doppler. METHODS:Thirty-six patients with myotonic dystrophy (M/F=20/16, ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.06.056

    authors： Parisi M,Galderisi M,Sidiropulos M,Fiorillo C,Lanzillo R,D'Errico A,Grieco M,Innelli P,Santoro L,de Divitiis O

    更新日期：2007-05-31 00:00:00

  • Differences in catheter ablation of paroxysmal atrial fibrillation between males and females.

    abstract：BACKGROUND:Catheter ablation (CA) has become a standard treatment for patients with atrial fibrillation (AF). However, gender-related differences associated with CA of paroxysmal AF (PAF) remain unclear. METHODS:We compared 1124 consecutive patients (mean age, 61 ± 10 years; male, n=864) with PAF scheduled for CA betw...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.12.101

    authors： Takigawa M,Kuwahara T,Takahashi A,Watari Y,Okubo K,Takahashi Y,Takagi K,Kuroda S,Osaka Y,Kawaguchi N,Yamao K,Nakashima E,Sugiyama T,Akiyama D,Kamiishi T,Kimura S,Hikita H,Hirao K,Isobe M

    更新日期：2013-10-03 00:00:00

  • Outpatient volumes and medical staffing resources as predictors for continuity of follow-up care during transfer of adolescents with congenital heart disease.

    abstract：BACKGROUND:Providing continuous follow-up care to patients with congenital heart disease (CHD) remains a challenge in many settings. Previous studies highlight that patients with CHD experience discontinuation of follow-up care, but mainly describe a single-centre perspective, neglecting inter-institutional variations....

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.01.016

    authors： Skogby S,Moons P,Johansson B,Sunnegårdh J,Christersson C,Nagy E,Winberg P,Hanséus K,Trzebiatowska-Krzynska A,Fadl S,Fernlund E,Kazamia K,Rydberg A,Zühlke L,Goossens E,Bratt EL

    更新日期：2020-07-01 00:00:00

  • Usefulness of basal B-type natriuretic peptide levels for the diagnosis of diastolic heart failure in young patients: an echocardiographic-catheterization study.

    abstract：:The aim of the present study was to address the diagnostic relevance of B-type natriuretic peptide (BNP) for the diagnosis of diastolic heart failure (DHF) in young patients presenting with chronic, isolated dyspnea. We prospectively included 26 consecutive patients with a left ventricular ejection fraction >50% refer...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.03.127

    authors： Arques S,Jaubert MP,Bonello L,Roux E,Armero S,Sbragia P,Nicoud A,Paganelli F

    更新日期：2010-11-05 00:00:00

  • Opening of calcium-activated potassium channels improves long-term left-ventricular function after coronary artery occlusion in mice.

    abstract：BACKGROUND:Opening of mitochondrial calcium-activated potassium channels (BKCa) reduces infarct size after myocardial ischemia/reperfusion injury (I/R). It is unknown if targeting BKCa-channels improves cardiac performance in the long-term after I/R. METHODS:Experiments were conducted in compliance with institutional ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.04.084

    authors： Behmenburg F,Hölscher N,Flögel U,Hollmann MW,Heinen A,Huhn R

    更新日期：2017-08-15 00:00:00