Abstract:
BACKGROUND:Lp(a), implicated in both atherogenesis and thrombosis pathways, varies significantly by demographic and metabolic factors, providing challenges for its use in Coronary Heart Disease (CHD) risk. The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in the prediction of CHD risk, as measured by coronary artery calcium (CAC). METHODS:We performed cross sectional analyses in two community-based studies: the Penn Diabetes Heart Study [N = 1299 with type-2 diabetes] and the Study of Inherited Risk of Coronary Atherosclerosis [N = 860 without diabetes]. RESULTS:Blacks had 2-3 fold higher Lp(a) levels than whites in diabetic and non-diabetic samples. There was significant difference by gender (interaction p<0.001), but not race, in the association of Lp(a) with CAC in type-2 diabetic subjects. In age and race adjusted analysis of diabetic women, Lp(a) was associated with CAC [Tobit regression ratio 2.76 (95% CI 1.73-4.40), p<0.001]. Adjustment for exercise, medications, Framingham risk score, metabolic syndrome, BMI, CRP and hemoglobin A1c attenuated this effect, but the association of Lp(a) with CAC remained significant [2.25, (1.34-3.79), p = 0.002]. This relationship was further maintained in women stratified by race, or by the use of HRT or lipid lowering drugs. In contrast, Lp(a) was not associated with CAC in diabetic men, nor in non-diabetic men and women. CONCLUSIONS:Lp(a) is a strong independent predictor of CAC in type-2 diabetic women, regardless of race, but not in men. Lp(a) does not relate to CAC in men or women without type-2 diabetes.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Qasim AN,Martin SS,Mehta NN,Wolfe ML,Park J,Schwartz S,Schutta M,Iqbal N,Reilly MPdoi
10.1016/j.ijcard.2010.02.021subject
Has Abstractpub_date
2011-07-01 00:00:00pages
17-21issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(10)00088-4journal_volume
150pub_type
杂志文章abstract::Doppler echocardiography is extensively used in clinical practice for the screening and detection of pulmonary hypertension (PH). It allows for accurate estimates of pulmonary artery pressures, but with moderate precision, which explains why it is more appropriate for population studies than for definitive diagnosis o...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2018.04.024
更新日期:2018-07-15 00:00:00
abstract:OBJECTIVE:Increased levels of neuro-hormonal biomarkers predict poor prognosis in patients with acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction (LVSD). The predictive value of repeated (one-month interval) brain natriuretic peptides (BNP) and big-endothelin 1 (BigET-1) measurement...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2017.02.018
更新日期:2017-08-15 00:00:00
abstract::A 73 year old woman, with previous history of coronary artery bypass grafting, was admitted for refractory unstable angina. The angiography revealed a significant stenosis of the ostium of the left subclavian artery. The patient underwent successful stenting of the subclavian artery and remained symptom free until hos...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.145
更新日期:2008-07-21 00:00:00
abstract::Separate origin of the left anterior descending and circumflex coronary artery from the left sinus of Valsalva is one of the most frequent benign coronary artery anomalies. We hereby report, for the first time, a case of sudden death in a young man with this anomaly. The clinicopathologic findings and the possible pat...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.08.124
更新日期:2009-03-20 00:00:00
abstract::A simple and rapid point-of-care platelet function assay that guides antiplatelet responses to aspirin and clopidogrel may be of great clinical value for the individual tailoring of therapy. The Plateletworks assay is based on single platelet counting and has been described as a promising point-of-care assay for the m...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.10.046
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To examine the association between health-related quality of life (HRQoL) and mortality in patients with heart failure (HF). BACKGROUND:The potential association of HRQoL and mortality in patients with HF is unclear. We investigated this association in The Danish Study to Assess the Efficacy of Implantable ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.02.008
更新日期:2020-04-15 00:00:00
abstract:BACKGROUND:Data with animal cells and models suggest that thrombin activates cardiac fibroblasts (Fib) to myofibroblasts (myoFib) via protease-activated receptor 1 (PAR1) cleavage, and in this way promotes adverse atrial remodeling and, thereby, atrial fibrillation (AF). OBJECTIVE:Here, we explored the effects of thro...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.05.033
更新日期:2018-11-15 00:00:00
abstract::Critically evaluating the methodology of the adventitial delivery of stem cells, some specific options should be underlined. Adventitia as the most superficial layer, consisting of connective tissue has to be distinguished of perivascular tissues. By strict definition, an adventitia is the outermost connective tissue ...
journal_title:International journal of cardiology
pub_type: 社论
doi:10.1016/j.ijcard.2012.11.063
更新日期:2013-05-10 00:00:00
abstract:AIMS:This study aimed to review the effectiveness of oral health promotion activities conducted among patients with cardiovascular disease. METHODS AND RESULTS:Three electronic databases were searched for effective papers using standardized search methods, and key findings of effective studies were summarized. The ini...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2010.11.014
更新日期:2011-09-15 00:00:00
abstract:OBJECTIVE:The wide spectrum of intracardiac anatomy and reparative surgery available for adults with congenital heart disease (ACHD) makes uniform measurement of cardiac size and disease severity challenging. The aim of this study was to assess the prognostic potential of cardiothoracic ratio, a simple marker of cardio...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.10.125
更新日期:2013-06-20 00:00:00
abstract::We describe a congenital aneurysm of the non-coronary sinus of Valsalva which extended into the posterior wall of the left ventricle. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90024-7
更新日期:1989-09-01 00:00:00
abstract:INTRODUCTION:Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.11.180
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The interaction of left ventricular outflow tract (LVOT) and transcatheter heart valve (THV) is complex and may be device design specific. We sought to study LVOT characteristics and its relation with permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR). METHODS:We stud...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.04.023
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Substance P (SP) may attenuate ischemia-reperfusion injury by reducing inflammation. We assessed cardioprotective effect of SP in a porcine model of acute myocardial infarction (AMI). METHODS:AMI was induced by occlusion of the left anterior descending artery on 28 swine, randomized to SP 5 nmol/kg (group 1...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.05.113
更新日期:2018-11-15 00:00:00
abstract::We reviewed the reports of 27 patients who had an aortic valve replacement after previous coronary artery bypass grafting. The aortic valve disease -- mainly aortic stenosis -- showed a rapid rate of progression. In the time interval between coronary artery bypass grafting and aortic valve replacement of 4.6+/-2.2 yea...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00018-7
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Lipid-lowering agents are known to reduce long-term mortality in patients with stable angina or multiple risk factors. However, the effects of lipid-lowering treatment on inflammatory process during and immediately after the acute phase of unstable angina remain unclear. In this study we assessed the effects...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2005.05.055
更新日期:2006-04-28 00:00:00
abstract::A 50-year-old woman who developed severe angina pectoris 67 months following radiation therapy of the left side of the chest for adenocarcinoma of the left breast is reported. Angiographic studies showed an isolated severe stenosis in the left anterior descending coronary artery. Successful percutaneous transluminal c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90323-3
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVES:To develop a quantitative event-free prediction model of late atrial arrhythmia after atrial septal defect (ASD) repair. BACKGROUND:The clinical management of ASD is driven by risk factors that determine the occurrence of late atrial arrhythmia. METHODS:Data from ASD type secundum patients, included in the...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.07.010
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:Premature acute myocardial infarction (AMI) is a rare disease carrying significant morbidity and mortality. Existing data on outcome in these patients is based on retrospective analysis of angiographic reports or refer to time periods with incomparable treatment regimes, making them unusable for risk assessm...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2017.03.146
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Myeloid differentiation factor-2 (MD-2) has been shown to be an important modulator of the innate immune system, but its role in cardiac diseases is unknown. We investigated whether MD-2 plays a role as risk predictor and contributor in dilated cardiomyopathy (DCM). METHODS AND RESULTS:We included 174 patie...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.06.025
更新日期:2018-11-01 00:00:00
abstract::To assess whether infarct size, ischemic area and/or survival correlates with circulating atrial natriuretic peptides (long acting sodium stimulator, vessel dilator, or atrial natriuretic factor), these peptides were measured in a canine model of acute myocardial infarction. Elevations in the circulating concentration...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)02192-l
更新日期:1995-01-06 00:00:00
abstract::Myocardial bridging is present when a segment of a major epicardial coronary artery, the 'tunnelled artery', runs intramurally through the myocardium. With each systole, the coronary artery is compressed. The pathophysiology of myocardial bridging is incompletely understood. With each systole, the coronary artery is c...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.03.106
更新日期:2012-01-26 00:00:00
abstract::Since increased heart rate (HR) is associated with higher mortality in several cardiac disorders, HR is considered not only a physiological indicator but also a prognostic and biological marker. In heart failure (HF), it represents a therapeutic target in chronic phase. The use or up-titration of beta-blockers, a mile...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2017.09.191
更新日期:2018-02-15 00:00:00
abstract::We sought to determine clinical characteristics as well as outcome of angina-free patients with chronic ischemic heart failure. In comparison with ischemic chest pain patients, angina-free patients have higher heart rate and systolic blood pressure on admission, lower number of diseased coronary artery vessels at coro...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.137
更新日期:2008-08-01 00:00:00
abstract::An anatomical study of 34 specimens presenting with tricuspid atresia, in which particular emphasis was devoted to the atrioventricular junctional area, revealed 5 cases with an imperforate valve. In 1 heart the valve was completely committed to the right ventricle. In the other 4, however, the membrane was related no...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(84)90006-8
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Cardiovascular risk-prediction models are used in clinical practice to identify and treat high-risk populations, and to communicate risk effectively. We assessed the validity and utility of four cardiovascular risk-prediction models in an Asian population of a middle-income country. METHODS:Data from a nati...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.07.066
更新日期:2014-09-01 00:00:00
abstract::It has been estimated that 5.1million Americans suffer from heart failure. Cognitive impairment has been described as a consequence of heart failure in numerous studies spanning the last three decades. This systematic review helps differentiate "cognitive impairment" into mild cognitive impairment, dementia, and delir...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2014.10.087
更新日期:2015-01-15 00:00:00
abstract:OBJECTIVES:Assessment of the long term outcome of mechanical valve prosthesis at pulmonary position in a population of grown-up congenital heart disease patients from a tertiary referral center. METHODS:From 1977 to 2007, 22 consecutive patients underwent a total of 25 pulmonary valve replacements with mechanical pros...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2010.04.004
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:Circulating C-reactive protein (CRP) is a marker of inflammation and is associated with the incidence of cardiovascular events. Although it has been known that adiponectin protects, whereas leptin accelerates, the development of atherosclerotic diseases, the comparative strength of their reciprocal effects o...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.01.006
更新日期:2008-11-12 00:00:00
abstract:INTRODUCTION:Studies evaluating changes in HRV preceding the onset of ventricular arrhythmias using conventional techniques have shown inconsistent results. Time-frequency analysis of HRV is traditionally performed using short-term Fourier transform (STFT). Wavelet transform (WT) may however be better suited for analyz...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2005.06.001
更新日期:2006-04-28 00:00:00