当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Ac

Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Ac

Abstract：

OBJECTIVE:Increased levels of neuro-hormonal biomarkers predict poor prognosis in patients with acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction (LVSD). The predictive value of repeated (one-month interval) brain natriuretic peptides (BNP) and big-endothelin 1 (BigET-1) measurements were investigated in patients with LVSD after AMI. METHODS:In a sub-study of the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS trial), BNP and BigET-1 were measured at baseline and at 1month in 476 patients. RESULTS:When included in the same Cox regression model, baseline BNP (p=0.0003) and BigET-1 (p=0.026) as well as the relative changes (after 1month) from baseline in BNP (p=0.049) and BigET-1 (p=0.045) were predictive of the composite of cardiovascular death or hospitalization for worsening heart failure. Adding baseline and changes in BigET-1 to baseline and changes in BNP led to a significant increase in prognostic reclassification as assessed by integrated discrimination improvement index (5.0%, p=0.01 for the primary endpoint). CONCLUSIONS:Both increased baseline and changes after one month in BigET-1 concentrations were shown to be associated with adverse clinical outcomes, independently from BNP baseline levels and one month changes, in patients after recent AMI complicated with LVSD. This novel result may be of clinical interest since such combined biomarker assessment could improve risk stratification and open new avenues for biomarker-guided targeted therapies. KEY MESSAGES:In the present study, we report for the first time in a population of patients with reduced LVEF after AMI and signs or symptoms of congestive HF, that increased baseline values of BNP and BigET-1 as well as a further rise of these markers over the first month after AMI, were independently predictive of future cardiovascular events. This approach may therefore be of clinical interest with the potential of improving risk stratification after AMI with reduced LVEF while further opening new avenues for biomarker-guided targeted therapies.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Olivier A,Girerd N,Michel JB,Ketelslegers JM,Fay R,Vincent J,Bramlage P,Pitt B,Zannad F,Rossignol P,EPHESUS Investigators.

doi

10.1016/j.ijcard.2017.02.018

subject

Has Abstract

pub_date

2017-08-15 00:00:00

pages

344-350

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)32115-5

journal_volume

241

pub_type

杂志文章,随机对照试验

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Risk of dementia and death in patients with atrial fibrillation: A competing risk analysis of a population-based cohort.

    abstract：BACKGROUND:Previous studies have stated that atrial fibrillation (AF) is associated with a higher risk of dementia. However, none have examined the competition between death and incident dementia in patients with AF. We evaluated the risk of incident dementia in patients with AF in comparison to people without this arr...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.235

    authors： Marzona I,Baviera M,Vannini T,Tettamanti M,Cortesi L,Riva E,Nobili A,Marcon G,Fortino I,Bortolotti A,Merlino L,Roncaglioni MC

    更新日期：2016-10-01 00:00:00

  • Electrocardiographic strain and endomyocardial radial strain in hypertensive patients.

    abstract：BACKGROUND:Electrocardiographic strain pattern (ECGS) is a well-recognized marker of the presence and severity of anatomic left ventricular hypertrophy (LVH) and also has been associated with adverse prognosis in hypertensive patients. Left ventricular (LV) endomyocardial radial strain (Endo-RS) is predominant in systo...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2010.04.049

    authors： Nakamura N,Hirata K,Imanishi T,Kuroi A,Arita Y,Ikejima H,Tsujioka H,Takemoto K,Tanimoto T,Kitabata H,Takarada S,Kubo T,Mizukoshi M,Tanaka A,Arita M,Akasaka T

    更新日期：2011-08-04 00:00:00

  • Prevalence of, associations with, and prognostic role of anemia in heart failure across the ejection fraction spectrum.

    abstract：BACKGROUND:The role of anemia in heart failure with mid-range and preserved ejection fraction (HFmrEF, EF 40-49% and HFpEF, EF ≥50%) is unknown. We aimed to compare prevalence of, associations with, and prognostic role of anemia in HF across the EF spectrum. METHODS:In patients from the Swedish HF Registry, we assesse...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.08.049

    authors： Savarese G,Jonsson Å,Hallberg AC,Dahlström U,Edner M,Lund LH

    更新日期：2020-01-01 00:00:00

  • The shape and function of the left ventricle in Ebstein's anomaly.

    abstract：BACKGROUND:Left ventricular (LV) failure is common in Ebstein's anomaly, though remains poorly understood. We investigated whether shape deformity impacts LV function. METHODS:Three-dimensional models of the right ventricle (RV) and LV from 29 adult Ebstein's patients and nine normal subjects were generated from cardi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.12.037

    authors： Goleski PJ,Sheehan FH,Chen SS,Kilner PJ,Gatzoulis MA

    更新日期：2014-02-15 00:00:00

  • Surgical repair of post-infarction ventricular septal defect: 19 years of experience.

    abstract：OBJECTIVES:To review our experience of surgical repair of post-infarction ventricular septal defect (VSD). METHODS:In the period 1983-2002, 50 patients underwent repair of VSD. Mean age was 66 years, male sex 52%. Infarct location was anterior in 60% and posterior in 40% of cases. Median interval between rupture and s...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2005.05.007

    authors： Mantovani V,Mariscalco G,Leva C,Blanzola C,Sala A

    更新日期：2006-04-04 00:00:00

  • 24 h and prolonged ambulatory ECG recording in patients with ventricular ectopy: Maybe 24 h are not enough?

    abstract：AIM:To assess whether 24-h ambulatory ECG (AECG) recording underestimates arrhythmic risk in subjects with both ventricular ectopy and cardiovascular risk factors or history of coronary heart disease (CHD). METHODS:29 consecutive patients with both ECG evidence of premature ventricular contractions (PVCs) and cardiova...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.02.055

    authors： Brunetti ND,D'Arienzo G,Tiscia G,Pellegrino PL,De Gennaro L,Di Biase M

    更新日期：2008-07-04 00:00:00

  • Moderate-to-high intensity inspiratory muscle training improves the effects of combined training on exercise capacity in patients after coronary artery bypass graft surgery: A randomized clinical trial.

    abstract：BACKGROUND:The effects of adding moderate-to-high intensity inspiratory muscle training (IMT) to short-term aerobic and resistance exercise (combined training [CT]), after coronary artery bypass grafting (CABG) are not established. This study aimed to determine the effects of moderate-to-high intensity IMT + CT on exer...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2018.12.013

    authors： Dos Santos TD,Pereira SN,Portela LOC,Cardoso DM,Lago PD,Dos Santos Guarda N,Moresco RN,Pereira MB,de Albuquerque IM

    更新日期：2019-03-15 00:00:00

  • Gender-related differences in patients with acute heart failure: management and predictors of in-hospital mortality.

    abstract：AIM AND METHODS:Gender-related differences in clinical phenotype, in-hospital management and prognosis of acute heart failure (AHF) patients have been previously reported in European and US registries. The ALARM-HF survey is the first to include a cohort of 4953 patients hospitalized for AHF in 666 hospitals in 6 Europ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.09.096

    authors： Parissis JT,Mantziari L,Kaldoglou N,Ikonomidis I,Nikolaou M,Mebazaa A,Altenberger J,Delgado J,Vilas-Boas F,Paraskevaidis I,Anastasiou-Nana M,Follath F

    更新日期：2013-09-20 00:00:00

  • Does Googling lead to statin intolerance?

    abstract：BACKGROUND:The nocebo effect, where patients with expectations of adverse effects are more likely to experience them, may contribute to the high rate of statin intolerance found in observational studies. Information that patients read on the internet may be a precipitant of this effect. The objective of the study was t...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2018.02.085

    authors： Khan S,Holbrook A,Shah BR

    更新日期：2018-07-01 00:00:00

  • Isolated ventricular noncompaction mimicking arrhythmogenic right ventricular cardiomyopathy--a study of nine patients.

    abstract：BACKGROUND:Isolated ventricular noncompaction is considered to predominantly affect the left ventricle. It is characterized by increased left ventricular wall thickness and deep intertrabecular recesses with to-and-fro blood flow that remains in continuity with the ventricular flow. Aim of the study was to present a gr...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.05.062

    authors： Wlodarska EK,Wozniak O,Konka M,Piotrowska-Kownacka D,Walczak E,Hoffman P

    更新日期：2010-11-05 00:00:00

  • Electrocardiographic left ventricular hypertrophy by five criteria among civil servants in Benin City, Nigeria: prevalence and correlates.

    abstract：:Although increasing hypertension rates have been reported in several African populations, little is known about the frequency of resulting hypertensive complications in these populations. We recorded the electrocardiograms of 482 male and 284 female civil servants in Benin City, Nigeria. Five different criteria were u...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(99)00061-3

    authors： Huston SL,Bunker CH,Ukoli FA,Rautaharju PM,Kuller LH

    更新日期：1999-07-01 00:00:00

  • Peri-procedural thrombocytopenia after aortic bioprosthesis implant: A systematic review and meta-analysis comparison among conventional, stentless, rapid-deployment, and transcatheter valves.

    abstract：BACKGROUND:Thrombocytopenia has been shown to occur soon after surgical biological aortic valve replacement (AVR), and recently reported also after transcatheter valve implantation (TAVI). The mechanism underlying this phenomenon is still unknown, and its clinical impact on the peri-operative outcome has been poorly in...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2019.07.056

    authors： Jiritano F,Santarpino G,Serraino GF,Ten Cate H,Matteucci M,Fina D,Mastroroberto P,Lorusso R

    更新日期：2019-12-01 00:00:00

  • Circulating endothelial progenitor cells in congestive heart failure.

    abstract：BACKGROUND:Endothelial progenitor cells (EPCs) circulate in the adult peripheral blood and contribute to neovascularization. EPCs are considered to be included in CD34 positive mononuclear cells (CD34+ MNCs). Kinetics of circulating EPCs in congestive heart failure (CHF) has not been fully investigated. METHODS:We det...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.07.191

    authors： Nonaka-Sarukawa M,Yamamoto K,Aoki H,Nishimura Y,Tomizawa H,Ichida M,Eizawa T,Muroi K,Ikeda U,Shimada K

    更新日期：2007-07-31 00:00:00

  • Impacts of valve intervention on the Functional REServe of the Heart: The FRESH-valve pilot study.

    abstract：PURPOSE:Severe valve lesions require corrective interventions to avoid progression to heart failure (HF) and premature demise. We tested the hypothesis that despite operative risks, corrective valvular interventions will lead to significant improvements in overall cardiac pump function, especially before the onset of c...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.03.177

    authors： Tan DK,Hothi SS,Macdonald W,Schlosshan D,Tan LB

    更新日期：2015-01-01 00:00:00

  • Does thrombolysis affect the prognostic value of the post-infarct exercise test?

    abstract：:There has been some debate on usefulness of the exercise test in risk stratification after myocardial infarction in the thrombolytic era. This was assessed in 295 patients of whom 184 were treated with thrombolysis. Each had an exercise test using a modified Naughton protocol within 14 days of acute myocardial infarct...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)90128-7

    authors： Wosornu D,Goh KY,Gooptu C,Beattie JM,Murray RG

    更新日期：1994-11-01 00:00:00

  • Temporal trends in management and outcome of diabetic and non-diabetic patients with acute coronary syndrome (ACS): residual risk of long-term mortality persists: Insights from the ACS Israeli Survey (ACSIS) 2000-2010.

    abstract：BACKGROUND/OBJECTIVES:In the past diabetes was strongly associated with elevated mortality rate after acute coronary syndrome (ACS). Over the past decade a treatment of the ACS has evolved rapidly with major advances in the management techniques. The aim of the present study was to compare temporal trends of the outcom...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.10.116

    authors： Klempfner R,Elis A,Matezky S,Keren G,Roth A,Finkelstein A,Banai S,Goldenberg I,Fisman EZ,Tenenbaum A,Arbel Y

    更新日期：2015-01-20 00:00:00

  • Rapid cardiac hybrid imaging with minimized radiation dose for accurate non-invasive assessment of ischemic coronary artery disease.

    abstract：BACKGROUND:Ischemic coronary artery disease (CAD) is a major cause for morbidity and mortality resulting in a continuously increasing number of diagnostic interventions. We have validated a new hybrid imaging method using minimized radiation dose for rapid non-invasive prediction of invasive coronary angiography (CA) f...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2010.08.023

    authors： Herzog BA,Husmann L,Buechel RR,Pazhenkottil AP,Burger IA,Valenta I,Altorfer U,Wolfrum M,Nkoulou RN,Ghadri JR,Wyss CA,Kaufmann PA

    更新日期：2011-11-17 00:00:00

  • Combined utility of brain natriuretic peptide and cardiac troponin T may improve rapid triage and risk stratification in normotensive patients with pulmonary embolism.

    abstract：BACKGROUND:Evaluation of the combined utility of brain natriuretic peptide (BNP) and cardiac troponin T (cTnT) for risk stratification in normotensive patients with acute pulmonary embolism. The changing patterns of BNP and cTnT levels during the initial management of pulmonary embolism and their correlation with clini...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.03.030

    authors： Tulevski II,ten Wolde M,van Veldhuisen DJ,Mulder JW,van der Wall EE,Büller HR,Mulder BJ

    更新日期：2007-03-20 00:00:00

  • Practices in management of cancer treatment-related cardiovascular toxicity: A cardio-oncology survey.

    abstract：BACKGROUND:Cardiovascular toxicity has become a challenging issue during cancer therapy. Nonetheless, there is a lack of consensual guidelines for their management. We aimed to determine the current practices of oncologists regarding cardiovascular toxicity related to anthracyclines, trastuzumab and angiogenic inhibito...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.02.154

    authors： Jovenaux L,Cautela J,Resseguier N,Pibarot M,Taouqi M,Orabona M,Pinto J,Peyrol M,Barraud J,Laine M,Bonello L,Paganelli F,Barlesi F,Thuny F

    更新日期：2017-08-15 00:00:00

  • CT vs conventional angiography in unselected patients with suspected coronary heart disease.

    abstract：BACKGROUND:To provide confirmatory evidence that the accuracy of MSCT coronary angiography is comparable to that of conventional coronary angiography. METHOD:19 patients who had both MSCT and conventional coronary angiography were included in our study. The mean age of our patients was 62.3 (SD 7.7) and 42% of our pat...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.08.057

    authors： Tan KT,Reed D,Howe J,Challenor V,Gibson M,McGann G

    更新日期：2007-09-14 00:00:00

  • Early detection of biventricular involvement in myotonic dystrophy by tissue Doppler.

    abstract：BACKGROUND:Myotonic dystrophy is associated with arrhythmias and risk of sudden death but also with symptoms of heart failure. Our study aimed to identify early biventricular dysfunction in asymptomatic patients with myotonic dystrophy by tissue Doppler. METHODS:Thirty-six patients with myotonic dystrophy (M/F=20/16, ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.06.056

    authors： Parisi M,Galderisi M,Sidiropulos M,Fiorillo C,Lanzillo R,D'Errico A,Grieco M,Innelli P,Santoro L,de Divitiis O

    更新日期：2007-05-31 00:00:00

  • Combined use of exercise electrocardiography, coronary calcium score and cardiac CT angiography for the prediction of major cardiovascular events in patients presenting with stable chest pain.

    abstract：BACKGROUND:The usual diagnostic work-up of chest pain patients includes clinical risk profiling and exercise-ECG, possibly followed by additional tests. Recently cardiac computed tomographic angiography (CCTA) has been employed. We evaluated the prognostic value of the combined use of exercise-ECG and CCTA for the deve...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2011.12.016

    authors： Versteylen MO,Joosen IA,Winkens MH,Laufer EM,Snijder RJ,Wildberger JE,Crijns HJ,Narula J,Hofstra L

    更新日期：2013-07-15 00:00:00

  • Intracoronary autologous bone marrow cell transplantation beneficially modulates heart rate variability.

    abstract：:The effect of intracoronary administration of autologous bone marrow cells on autonomic modulation of heart rate has not yet been demonstrated. Therefore, we investigated different parameters of heart rate variability (HRV) in 46 patients without (n=23) or with (n=23) intracoronary stem cell therapy after transmural m...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.07.169

    authors： Schueller PO,Meyer C,Brehm M,Wernet P,Schannwell CM,Strauer BE

    更新日期：2007-07-31 00:00:00

  • Increased risk for ascending aortic dilatation in patients with complex compared to simple aortic coarctation.

    abstract：AIMS:Aortic coarctation (CoA) occurs as a "simple" isolated disorder, and in a more "complex" form, combined with associated congenital cardiac abnormalities. Long term outcome of all CoA patients may be complicated by dilatation of the thoracic aorta. The aim of this study was to quantify progressive aortic dilatation...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.02.014

    authors： Luijendijk P,Franken RJ,Vriend JW,Zwinderman AH,Vliegen HW,Winter MM,Groenink M,Bouma BJ,Mulder BJ

    更新日期：2013-08-10 00:00:00

  • Simple electrocardiographic markers for the prediction of paroxysmal atrial fibrillation in hyperthyroidism.

    abstract：BACKGROUND:Hyperthyroidism is a major cause of paroxysmal atrial fibrillation (AF). The purpose of this study was to evaluate the predictors of AF in the patients with clinical and subclinical hyperthyroidism. METHODS AND RESULTS:The study population consisted of four groups: group I (57 euthyroid healthy persons), gr...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2003.11.040

    authors： Aras D,Maden O,Ozdemir O,Aras S,Topaloglu S,Yetkin E,Demir AD,Soylu MO,Erdogan MF,Kisacik HL,Korkmaz S

    更新日期：2005-03-10 00:00:00

  • Transjugular liver biopsy for Fontan associated liver disease surveillance: Technique, outcomes and hemodynamic correlation.

    abstract：BACKGROUND:Fontan associated liver disease (FALD) is attributed to the limitations of the Fontan circulation, resulting in congestive hepatopathy. The technique and outcomes of transjugular liver biopsies (TJLB) in Fontan patients warrant definition as part of a rigorous FALD surveillance program. METHOD:Four year rev...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.11.037

    authors： Borquez AA,Silva-Sepulveda J,Lee JW,Vavinskaya V,Vodkin I,El-Sabrout H,Towbin R,Perry JC,Moore JW,El-Said HG

    更新日期：2020-12-02 00:00:00

  • Is addition of angiotensin receptor blockade superior to increasing ACE inhibitor dose in patients with heart failure?

    abstract：:We conducted a prospective, randomised, open-label, blinded end point (PROBE) study examining the relative efficacy of irbesartan 300 mg/day versus maximising dose of ACE inhibitor, additional to background conventional heart failure therapy. Patients with CHF, NYHA Class II-III and a left ventricular ejection fractio...

    journal_title：International journal of cardiology

    pub_type： 信件,多中心研究,随机对照试验

    doi：10.1016/j.ijcard.2008.10.022

    authors： Brack J,Sindone A,Funston R,Schneider H,Skiba M,Ueng KC,Krum H

    更新日期：2010-03-18 00:00:00

  • A nonreentrant arrhythmia due to a dual atrioventricular nodal pathway.

    abstract：:A 33-year-old woman presented with an atypical arrhythmia. The electrophysiologic study revealed dual atrioventricular nodal pathways. The difference in conductivity of these tracts enabled simultaneous atrioventricular conduction with a double ventricular response to a single atrial impulse. This disturbance is uncom...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(90)90036-5

    authors： Mádle A

    更新日期：1990-02-01 00:00:00

  • Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress.

    abstract：BACKGROUND:Neuregulin1 (Nrg1) and its receptors ErbB are crucial for heart development and for adult heart structural maintenance and function and Nrg1 has been proposed for heart failure treatment. Infarct size is the major determinant of heart failure and the mechanism of action and the role of each ErbB receptor rem...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.01.122

    authors： Morano M,Angotti C,Tullio F,Gambarotta G,Penna C,Pagliaro P,Geuna S

    更新日期：2017-04-15 00:00:00

  • Oral anticoagulation and clinical outcomes in COVID-19: An Italian multicenter experience.

    abstract：BACKGROUND:Since the body of evidence addressing the coagulation derangements caused by Coronavirus disease (COVID-19) has been constantly growing, we investigated whether pre-hospitalization oral anticoagulation (OAC) or in-hospital heparin treatment could have a protective role among COVID-19 patients. METHOD:In thi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2020.09.001

    authors： Schiavone M,Gasperetti A,Mancone M,Curnis A,Mascioli G,Mitacchione G,Busana M,Sabato F,Gobbi C,Antinori S,Galli M,Forleo GB

    更新日期：2021-01-15 00:00:00