Abstract：
BACKGROUND:Previous studies have stated that atrial fibrillation (AF) is associated with a higher risk of dementia. However, none have examined the competition between death and incident dementia in patients with AF. We evaluated the risk of incident dementia in patients with AF in comparison to people without this arrhythmia, considering of the competing risk of death. METHODS:AF and non-AF cohorts were identified using the large administrative database of the Lombardy Region and followed for ten years. Patients with incident dementia were identified if they had an ICD 9 code referring to dementia at hospital discharge or a prescription for any anti-dementia drug. The association of AF with dementia or death was assessed with the multivariable Cox proportional-regression model, sensitivity analysis with a 1:1 propensity score matching and competing-risk analysis. RESULTS:In 2003 a total of 27,431 patients were hospitalized for AF in the Lombardy Region, while the cohort of non-AF counted 1,600,200 people. AF was associated with a higher risk of dementia (17%) and death (51%) at multivariable Cox analysis. These results were confirmed by the model fitted after propensity score matching. However, competing risk analysis found the association between AF and incident dementia was no longer significant (HR 0.99; 95% CI 0.94-1.04). CONCLUSIONS:In this real-world population the association between AF and dementia was no longer statistically significant when death was considered a competing risk.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Marzona I,Baviera M,Vannini T,Tettamanti M,Cortesi L,Riva E,Nobili A,Marcon G,Fortino I,Bortolotti A,Merlino L,Roncaglioni MCdoi
10.1016/j.ijcard.2016.06.235subject
Has Abstractpub_date
2016-10-01 00:00:00pages
440-4eissn
0167-5273issn
1874-1754pii
S0167-5273(16)31240-2journal_volume
220pub_type
杂志文章abstract：BACKGROUND:The efficacy and safety of warfarin for stroke prevention in atrial fibrillation (AF) depend on the time in the therapeutic range (TTR) with an international normalised ratio (INR) of 2.0-3.0. This meta-analysis focused the relative efficacy and safety of non-VKA oral anticoagulants (NOAC) compared with warf...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ijcard.2017.06.004
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:The clinical outcomes for women compared with men undergoing left main PCI were sparse. We compared the characteristics and long-term outcomes in women versus men after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for unprotected left main CAD. METHODS:We identified 2328 patients ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.06.051
更新日期：2018-02-15 00:00:00
abstract：BACKGROUND:The EUROASPIRE I, II and III surveys revealed high prevalences of modifiable risk factors in the high priority group of coronary patients all over Europe. The potential to further reduce coronary heart disease (CHD) morbidity and mortality rates is still considerable. We report here on the relative risk of c...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.10.051
更新日期：2013-09-30 00:00:00
abstract：BACKGROUND:Previous studies demonstrated that scar tissue assessed by late gadolinium enhancement cardiovascular magnetic resonance imaging (LGE-CMR) is associated with recovery of cardiac function after coronary artery bypass graft (CABG) in patients with a history of myocardial infarction (MI). However, information o...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.10.052
更新日期：2020-12-06 00:00:00
abstract：BACKGROUND:Unwitnessed OHCA patients with non-shockable initial rhythms account for nearly half of all OHCA patients, and their prognosis is extremely poor. To date, no studies have focused on these patients. This study aimed to investigating the predictors of favorable and poor prognosis in these patients. METHODS:We...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.08.057
更新日期：2014-10-20 00:00:00
abstract：BACKGROUND:In patients with chronic obstructive pulmonary disease (COPD) weight loss frequently occurs that may ultimately lead to cachexia as a serious co-morbidity, indicating severely impaired functional capacity, health status and increased mortality. Increased energy expenditure due to mechanic and metabolic ineff...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2006.07.088
更新日期：2007-06-25 00:00:00
abstract：:Depression and anxiety are well-known to be associated with adverse health outcomes in cardiac patients. However, there has been less work synthesizing the effects of positive psychological constructs (e.g., optimism) on health-related outcomes in cardiac patients. We completed a systematic review of prospective obser...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2015.05.121
更新日期：2015-09-15 00:00:00
abstract：BACKGROUND:Although atrial fibrillation (AF) is an important cause of cardiovascular morbidity and mortality there is a paucity of data describing hospitalisation rates and case-fatality associated with this common arrhythmia. This study examines recent trends in first-ever hospitalisations for AF in Scotland. METHODS...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(01)00626-x
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:The nocebo effect, where patients with expectations of adverse effects are more likely to experience them, may contribute to the high rate of statin intolerance found in observational studies. Information that patients read on the internet may be a precipitant of this effect. The objective of the study was t...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2018.02.085
更新日期：2018-07-01 00:00:00
abstract：:Central obesity is closely linked to hypertension and type-2 diabetes (DM2) in young/middle-age. In the elderly, systolic hypertension is a reflection of aging/stiff arteries. Diastolic (± systolic) hypertension in young/middle-age is accompanied by increased sympathetic nerve activity, particularly in the presence of...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2014.04.204
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Levosimendan is an inodilator developed for treatment of acute heart failure and other cardiac conditions where the use of an inodilator is considered appropriate. Levosimendan has been studied in different therapeutic settings including acutely decompensated chronic heart failure, advanced heart failure, ri...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ijcard.2016.02.014
更新日期：2016-04-15 00:00:00
abstract：:Cardiotoxicity is a recognised side effect of intravenous 5-fluorouracils. In the two case reports described we demonstrate similar cardiotoxic side effects seen with the use of capecitabine. With the increasing use of oral adjuvant chemotherapeutic agents, capecitabine should be used with caution in those patients wi...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2007.06.152
更新日期：2008-10-30 00:00:00
abstract：OBJECTIVE:To assess benefit and harms of adding an eHealth intervention to health education and individual counseling in adolescents with congenital heart disease. DESIGN:Randomized clinical trial. SETTING:Denmark. PATIENTS:A total of 158 adolescents aged 13-16years with no physical activity restrictions after repai...
journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijcard.2016.07.092
更新日期：2016-10-15 00:00:00
abstract：BACKGROUND:According to recent clinical trial data, correction of iron deficiency with intravenous (i.v.) iron has favorable outcomes on cardiac function. We evaluated whether i.v. iron treatment of anemic rats has favorable effect on the left ventricular (LV) performance and remodeling and the role of oxidative/nitros...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.03.039
更新日期：2016-06-01 00:00:00
abstract：:The effect and choice of a drug to control heart rate for symptomatic improvement in patients with isolated mitral stenosis with normal sinus rhythm (n = 10) or atrial fibrillation (n = 10) were studied. Digoxin (0.25-0.5 mg daily), metoprolol (50-100 mg twice a day) and verapamil (40-80 mg three times a day) were eva...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-5273(89)90223-4
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:To determine the risk and predictors of progression of aortic regurgitation (AR) and other adverse events (AE) in adults with supracristal ventricular septal defect (VSD). METHODS:Retrospective observational study of 62 adults with supracristal VSD followed at the Mayo Clinic from 1994 to 2013. Freedom from...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2015.06.100
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:Aim of this study was to evaluate different response in platelet reactivity and vessel healing using high-resolution frequency-domain optical coherence tomography (FD-OCT) in patients with femoropopliteal artery disease treated with ZILVER PTX drug eluting stents (DES), and randomly assigned to clopidogrel o...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.01.024
更新日期：2020-04-01 00:00:00
abstract：:The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV). ECG ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.03.082
更新日期：2009-08-14 00:00:00
abstract：BACKGROUND:Acute heart failure (HF) is a frequently encountered cardiac condition. Its prevalence increases exponentially with age. In spite of this, elderly patients are underrepresented in clinical trials and the implementation of guideline-based medical therapy (GBMT) in them is not well established. We investigated...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.02.070
更新日期：2017-05-15 00:00:00
abstract：BACKGROUNDS:Predicting left atrial appendage thrombus (LAAT) in non-valvular atrial fibrillation (NVAF) patients need more precisely quantified risk models. In this study, we attempted to review the risk markers for LAAT and develop a simple and reliable model for LAAT prediction. METHODS:The study included 307 patien...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.04.039
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Clinicians and other stakeholders recognize the need for clinical registries to monitor data in order to improve the outcome and quality of care in the delivery of medical interventions. The establishment of a collaboration across the Asia Pacific Region to inform on variations in patient and procedural char...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2013.12.030
更新日期：2014-03-01 00:00:00
abstract：:To assess the possible role of restoring forces underlying left ventricular wall motion during rapid filling, the time relations between left ventricular dimensions and filling velocity were studied by digitised M-mode and Doppler echocardiography in 23 normal children and 43 patients: 11 with mild and 17 with severe ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(89)90014-4
更新日期：1989-09-01 00:00:00
abstract：:The effect of flecainide acetate, a class 1c antiarrhythmic agent, was examined in 15 patients with recurrent ventricular tachycardia. Intravenous flecainide was administered in a dose of 2 mg/kg at the time of intracardiac stimulation and recording studies. Oral flecainide was given to 10/15 patients and retesting wa...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(86)90007-0
更新日期：1986-03-01 00:00:00
abstract：:A two-year-old patient had an atrial septal defect associated with a remnant of the valve of the sinus venosus which produced an unusual drainage of the inferior caval vein. The preoperative knowledge of the unusual anatomy allowed the surgeon to repair the anomaly without difficulties. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(86)90122-1
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:Coronary artery spasm (CAS) and significant coronary stenosis are known to be major causes of myocardial ischemia. However, their association and the impact of insignificant coronary stenosis (ICS) on long-term clinical outcomes of CAS patients are largely unknown. METHODS:A total of 2797 patients without s...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.03.081
更新日期：2017-07-01 00:00:00
abstract：:The pathogenesis of double outlet right ventricle with or without pulmonary infundibular atresia in mouse fetal trisomy 13 was studied at the organ level using microdissection and scanning electron microscopy. Altogether, 394 karyotyped trisomic embryos were collected between 11 days and 16 hours of gestation (presenc...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90359-w
更新日期：1991-11-01 00:00:00
abstract：:Seventy-one patients submitted routinely to coronary artery bypass surgery were randomized into 2 groups. Group A (32 patients) received 24 hr after initiation of surgery an intravenous perfusion of 100 mg of acebutolol given over 24 hr (22 cases) or 600 mg administered orally (10 cases). On subsequent days, they rece...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-5273(85)90219-0
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:Optical coherence tomography (OCT) is an intravascular imaging modality capable of providing in situ images of tissues at near histologic resolution. In this study we examine the utility of OCT in identifying vascular changes related to pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmona...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.07.215
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Thrombocytopenia has been shown to occur soon after surgical biological aortic valve replacement (AVR), and recently reported also after transcatheter valve implantation (TAVI). The mechanism underlying this phenomenon is still unknown, and its clinical impact on the peri-operative outcome has been poorly in...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ijcard.2019.07.056
更新日期：2019-12-01 00:00:00
abstract：:A patient undergoing coronary artery bypass was found to have a giant epicardial lipoma weighing 1.36 kg which was excised uneventfully. The radiological and pathophysiological features are considered, and the options for management discussed. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90140-x
更新日期：1992-10-01 00:00:00
