Abstract:
BACKGROUND:Optical coherence tomography (OCT) is an intravascular imaging modality capable of providing in situ images of tissues at near histologic resolution. In this study we examine the utility of OCT in identifying vascular changes related to pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS:OCT of four different distal pulmonary arteries was performed during right heart catheterization in 87 patients, 64 patients with PAH and 23 patients with CTEPH. The mean luminal diameter measured by OCT for all patients was 2.26mm. Intimal thickening was significantly increased in all PAH patients (0.26±0.05mm in idiopathic PAH, 0.24±0.03mm in connective tissue disease related PAH, 0.26±0.06mm in congenital heart disease related PAH and 0.22±0.04mm in CTEPH, respectively) compared with controls (0.13±0.03mm) (all p<0.05). An intimal thickness of ≥0.176mm had a 91% positive predictive value for pulmonary hypertension. The anatomic abnormalities revealed by OCT tended to be severe in the idiopathic PAH group and mild in the CTEPH group. Signs of intravascular webs were found in 60.9% of CTEPH patients, but no other patients. Intimal thickness was moderately correlated with pulmonary arterial pressure and pulmonary vascular resistance (r=0.423 and 0.439, respectively, p<0.001). CONCLUSIONS:OCT provides important information for assessment of pulmonary arterial remodeling in patients with PAH and improves diagnostic capability of angiographically undetected distal-thrombotic lesions in patients with CTEPH.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Jiang X,Peng FH,Liu QQ,Zhao QH,He J,Jiang R,Wang L,Xu XQ,Li JH,Ebrahimi R,Jing ZCdoi
10.1016/j.ijcard.2016.07.215subject
Has Abstractpub_date
2016-11-01 00:00:00pages
494-498eissn
0167-5273issn
1874-1754pii
S0167-5273(16)31609-6journal_volume
222pub_type
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