Sex differences in left main coronary artery stenting: Different characteristics but similar outcomes for women compared with men.

Abstract:

BACKGROUND:The clinical outcomes for women compared with men undergoing left main PCI were sparse. We compared the characteristics and long-term outcomes in women versus men after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for unprotected left main CAD. METHODS:We identified 2328 patients (545 women; 1783 men) with unprotected left main CAD who received PCI with DES between January 2007 and December 2013 in the Interventional Cardiology Research In-cooperation Society-left MAIN revascularization (IRIS-MAIN) registry. The primary outcome was a composite of death from any cause, myocardial infarction, or stroke. RESULTS:The median follow-up time was 2.9years (interquartile range: 1.0-4.1years). Women were older, had a higher incidence of insulin-requiring diabetes mellitus and hypertension, and more commonly presented with acute coronary syndrome than men. Left main ostial lesion was more common in women, whereas left main bifurcation lesion with more extensive CAD was more common in men. The incidence of primary outcome was similar between the two groups (10.8% vs. 10.8%, respectively, log-rank p=0.587). The results were similar after adjustment for baseline variables and consistent across major subgroups. The need for target lesion revascularization was significantly higher in women than in men (8.8% vs. 5.7%, respectively, p<0.05) but the sex bias was not confirmed after adjusting for confounders. CONCLUSIONS:Women, as compared to men, had different clinical and lesion characteristics but similar long-term outcomes after PCI with DES for left main CAD.

journal_name

Int J Cardiol

authors

Shin ES,Lee CW,Ahn JM,Lee PH,Chang M,Kim MJ,Yoon SH,Park DW,Kang SJ,Lee SW,Kim YH,Park SW,Park SJ

doi

10.1016/j.ijcard.2017.06.051

subject

Has Abstract

pub_date

2018-02-15 00:00:00

pages

50-54

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)30271-1

journal_volume

253

pub_type

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