当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia.

Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia.

Abstract：

OBJECTIVE:Because the lipoprotein effects of statin and fibric acid derivatives therapies differ, we studied the effects of these therapies in patients with hyperlipidemia on lipoproteins, vasomotor function, and plaque stability. METHODS:We administered simvastatin, 20 mg daily, to 27 patients with hypercholesterolemia and coronary artery disease, or fenofibrate, 200 mg daily, to 27 patients with pure hypertriglyceridemia during 8 weeks. RESULTS:As expected, simvastatin significantly lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) more, and fenofibrate decreased triglyceride and increased high-density lipoprotein cholesterol (HDL-C) more than either therapy. Simvastatin and fenofibrate significantly improved the percent flow-mediated dilator response to hyperemia by 183+/-41% and by 30+/-7%, respectively (each P<0.001); however, simvastatin significantly improved more (P<0.001). Simvastatin and fenofibrate significantly lowered plasma levels of tumor necrosis factor alpha (TNF-alpha) by 13+/-4% and by 10+/-4%, respectively (P=0.009 and P=0.006, respectively) with a similar degree (P=0.614). Simvastatin significantly reduced plasma levels of total MMP-9 and TIMP-1 more (P=0.005 and P=0.036, respectively), compared with fenofibrate showing no reduction. There were significant correlations between the degree of changes in TNF-alpha and the degree of changes in MMP-9 activity (r=0.376, P=0.053). CONCLUSIONS:Simvastatin and fenofibrate demonstrated antiatherosclerotic effects via different mechanisms.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Koh KK,Ahn JY,Jin DK,Han SH,Kim HS,Choi IS,Ahn TH,Shin EK,Jeong EM

doi

10.1016/j.ijcard.2003.09.007

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

239-44

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167527303006247

journal_volume

97

pub_type

临床试验,杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Lifestyle advice and interventions for cardiovascular risk reduction: A systematic review of guidelines.

    abstract：BACKGROUND:Lifestyle factors are important in preventing cardiovascular disease (CVD) development. We aimed to systematically review guidelines on primary prevention of CVD and their recommendations on lifestyle advice or intervention, in order to guide primary prevention programs. METHODS:Publications in MEDLINE, CIN...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.02.094

    authors： Khanji MY,van Waardhuizen CN,Bicalho VVS,Ferket BS,Hunink MGM,Petersen SE

    更新日期：2018-07-15 00:00:00

  • Valsalva maneuver: a test of the functional state of cardiac innervation in Chagasic myocarditis.

    abstract：:The ratio between maximal and minimal R-R intervals measured during the Valsalva maneuver is an adequate means of studying the functional state of the cardiac parasympathetic nervous system. We studied the changes in heart rate evoked during the Valsalva maneuver in 49 asymptomatic Chagasic patients with different deg...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(88)90053-8

    authors： Fuenmayor AJ,Rodriguez L,Torres A,Donís J,Navas M,Fuenmayor AM,Dávila D

    更新日期：1988-03-01 00:00:00

  • Remodeling in acute coronary syndromes: expectations and frustrations for risk assessment and therapy.

    abstract：:Matrix metalloproteinases are involved in the development of acute coronary syndromes, but they are not reliable clinical markers of the occurrence or the outcome of this syndrome. Many limitations in their assessment account for such failure. Functional genetic polymorphisms, as alternatives to plasma levels, might b...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2008.04.005

    authors： Fiotti N,Altamura N,Giansante C

    更新日期：2009-05-29 00:00:00

  • C-reactive protein and microalbuminuria are associated with atrial fibrillation.

    abstract：BACKGROUND:Atrial fibrillation (AF) is associated with an increased risk for cardiovascular disease. It is important to detect AF at an early stage and to search for new pathophysiological pathways to intervene. We hypothesized that microalbuminuria and C-reactive protein (CRP), a marker of generalized vascular damage ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2003.12.028

    authors： Asselbergs FW,van den Berg MP,Diercks GF,van Gilst WH,van Veldhuisen DJ

    更新日期：2005-01-01 00:00:00

  • Usefulness of basal B-type natriuretic peptide levels for the diagnosis of diastolic heart failure in young patients: an echocardiographic-catheterization study.

    abstract：:The aim of the present study was to address the diagnostic relevance of B-type natriuretic peptide (BNP) for the diagnosis of diastolic heart failure (DHF) in young patients presenting with chronic, isolated dyspnea. We prospectively included 26 consecutive patients with a left ventricular ejection fraction >50% refer...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.03.127

    authors： Arques S,Jaubert MP,Bonello L,Roux E,Armero S,Sbragia P,Nicoud A,Paganelli F

    更新日期：2010-11-05 00:00:00

  • Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke.

    abstract：:There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes me...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.12.053

    authors： Muscogiuri G,Annweiler C,Duval G,Karras S,Tirabassi G,Salvio G,Balercia G,Kimball S,Kotsa K,Mascitelli L,Bhattoa HP,Colao A

    更新日期：2017-03-01 00:00:00

  • Severe right ventricular dysfunction following pericardiocentesis for cardiac tamponade.

    abstract：:The accumulation of fluid in the pericardium in an amount sufficient to cause severe obstruction to blood inflow to the ventricles results in cardiac tamponade. In this condition, relief of intrapericardial pressure by pericardiocentesis usually dramatically improves cardiac output, and can be lifesaving. We report a ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/s0167-5273(97)02918-5

    authors： Anguera I,Paré C,Perez-Villa F

    更新日期：1997-04-18 00:00:00

  • When office blood pressure measurement is not enough.

    abstract：:Further efforts in controlling blood pressure are warranted in patients with hypertension. Office blood pressure measurements, 24-h ambulatory blood pressure monitoring and home blood pressure monitoring are synergic techniques. But, according to available evidence about efficacy and cost-effectiveness of all these te...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2009.05.044

    authors： Barrios V,Escobar C,Echarri R

    更新日期：2010-11-05 00:00:00

  • High throughput bioassay for beta1-adrenoceptor autoantibody detection.

    abstract：BACKGROUND:While the involvement of adrenergic beta1-autoantibodies (beta1-AABs) in pathogenesis of cardiomyopathies is well established as are the benefits associated with autoantibody removal by immunoapheresis, the development of drugs neutralizing beta1-AABs in-vivo has been slowed due to a lack of high throughput ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.002

    authors： Joshi-Barr S,Haberland A,Bartel S,Müller J,Choi T,Wallukat G

    更新日期：2016-09-15 00:00:00

  • Coronary risk factors and coronary atheroma burden at severely narrowing segments.

    abstract：BACKGROUND:While only few data exist correlating cardiovascular risk factors with volumetric measurements of coronary atheroma burden in patients with coronary artery disease, a recent report using intravascular ultrasound (IVUS) demonstrated independent predictors of atherosclerotic burden in a native coronary artery ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.11.194

    authors： Kaneda H,Kataoka T,Ako J,Honda Y,Yock PG,Fitzgerald PJ

    更新日期：2008-02-20 00:00:00

  • Interruption of aortic arch associated with pulmonary valve stenosis.

    abstract：:A newborn male is described who presented with interruption of aortic arch associated with ventricular septal defect and pulmonary valve stenosis. He underwent total corrective surgery and was discharged with good clinical results. The combination of significant right ventricular outflow obstruction and interruption o...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)02263-i

    authors： Matsushita T,Nakajima T,Kishimoto H

    更新日期：1995-03-24 00:00:00

  • Beta-blockers for chronic heart failure: surviving longer but feeling better?

    abstract：:Beta-blockers, as determined by four landmark placebo-controlled studies, impart a significant survival advantage to the chronic heart failure population. What ancillary benefits might be expected from beta-blockade, in terms of symptom relief and improvement in exercise capacity, is less clear. This situation in part...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0167-5273(03)00050-0

    authors： Bolger AP,Al-Nasser F

    更新日期：2003-11-01 00:00:00

  • A validation study of intraoperative performance metrics for training novice cardiac resynchronization therapy implanters.

    abstract：AIMS:Pacing/cardiac resynchronization therapy (CRT) implant training currently lacks a common system to objectively assess trainee ability to perform required tasks at predetermined performance levels. The purpose of this study was to primarily examine construct validity and reliability, secondarily discriminative vali...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.02.003

    authors： Mascheroni J,Mont L,Stockburger M,Patwala A,Retzlaff H,Gallagher AG

    更新日期：2020-05-15 00:00:00

  • Isolated congenital left ventricular diverticulum in an elderly patient that was identified because of an incidental finding during a complete medical checkup.

    abstract：:Congenital left ventricular diverticulum is a rare cardiac malformation in an elderly patient. It frequently is associated with other cardiac or non-cardiac congenital malformations. We present an asymptomatic elderly patient, evaluated because of an incidental finding of a left ventricular anatomic change on chest co...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.04.106

    authors： Sakabe K,Fukuda N,Fukuda Y,Wakayama K,Nada T,Morishita S,Shinohara H,Tamura Y

    更新日期：2008-04-10 00:00:00

  • Reduced flow-mediated vasodilation of brachial artery in children with primary snoring.

    abstract：BACKGROUND:Sleep disordered breathing, especially obstructive sleep apnea, is associated with endothelial dysfunction in both adults and children. However, the role of primary snoring (PS) on endothelial function has not been investigated. This study aimed to examine flow-mediated vasodilation (FMD) in both normal weig...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.05.108

    authors： Li AM,Au CT,Chook P,Lam HS,Wing YK

    更新日期：2013-09-01 00:00:00

  • Valsalva maneuver to predict dynamic intraventricular obstruction during dobutamine stress echocardiography in patients with hypertension.

    abstract：BACKGROUND:We were to evaluate the effect of Valsalva maneuver with comparison to preload reduction by nitroglycerin (NTG) to predict intraventricular obstruction (IVO) during dobutamine stress echocardiography (DSE) in patients with hypertension. METHODS:A total of 38 hypertensive patients (mean age 66.0±9.9 years; 3...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.03.069

    authors： Sohn IS,Lee JB,Park JH,Cho JM,Kim CJ

    更新日期：2010-10-29 00:00:00

  • Multiple interventions following an acute coronary syndrome event increase uptake into cardiac rehabilitation.

    abstract：AIMS:Cardiac rehabilitation (CR) improves morbidity and mortality. Uptake varies for patients following acute coronary syndrome (ACS). Entry into CR is often dependent on the management strategy received, lower following percutaneous coronary intervention (PCI), higher following coronary artery bypass grafting (CABG). ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.11.005

    authors： Lawless M,Harrison AS,Doherty P

    更新日期：2020-11-10 00:00:00

  • Updated evidence on early statin therapy for acute coronary syndromes: meta-analysis of 18 randomized trials involving over 14,000 patients.

    abstract：BACKGROUND:The short-term effects of early statin therapy in acute coronary syndromes (ACS) on clinical outcomes remain unclear. Our objective was to update the evidence on patient relevant outcomes from all randomized trials comparing early statin therapy with placebo or usual care at 1 and 4 months following ACS. ME...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2011.01.033

    authors： Briel M,Vale N,Schwartz GG,de Lemos JA,Colivicchi F,den Hartog FR,Ostadal P,Macin SM,Liem A,Mills E,Bhatnagar N,Bucher HC,Nordmann AJ

    更新日期：2012-06-28 00:00:00

  • Coronary stent strut fracture after drug-eluting stent implantation: a newly recognized complication.

    abstract：:Stent strut fracture (SSF) after drug-eluting stent (DES) implantation may be an important complication after DES implantation particularly in patients undergoing sirolimus eluting stent implantation. Since SSF is a highly relevant adverse event which can result in in-stent restenosis and thrombosis, we believe that D...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2007.07.011

    authors： Celik T,Iyisoy A,Dogru MT,Isik E

    更新日期：2009-02-06 00:00:00

  • Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women.

    abstract：BACKGROUND:Lp(a), implicated in both atherogenesis and thrombosis pathways, varies significantly by demographic and metabolic factors, providing challenges for its use in Coronary Heart Disease (CHD) risk. The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might be...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2010.02.021

    authors： Qasim AN,Martin SS,Mehta NN,Wolfe ML,Park J,Schwartz S,Schutta M,Iqbal N,Reilly MP

    更新日期：2011-07-01 00:00:00

  • Effects of disopyramide on the atrial fibrillation threshold in the human atrium.

    abstract：:The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0167-5273(95)02467-b

    authors： Ishibashi K,Inoue D,Sakai R,Inoue M,Shirayama T,Asayama J,Nakagawa M

    更新日期：1995-11-24 00:00:00

  • Safety and efficacy of non-vitamin K antagonist oral anticoagulants for prevention of thromboembolism in adults with systemic right ventricle: Results from the NOTE international registry.

    abstract：BACKGROUND:Patients with systemic right ventricle (sRV), including transposition of great arteries (TGA) after atrial switch procedure and congenitally corrected transposition of great arteries (ccTGA), may require anticoagulation for thromboembolism (TE) prevention. In the absence of data on non-vitamin K antagonist o...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.08.034

    authors： Scognamiglio G,Fusco F,Hankel TC,Bouma BJ,Greutmann M,Khairy P,Ladouceur M,Dimopoulos K,Niwa K,Broberg CS,Miranda B,Budts W,Bouchardy J,Schwerzmann M,Lipczyńska M,Tobler D,Tsai SF,Egbe AC,Aboulhosn J,Fernandes SM,

    更新日期：2021-01-01 00:00:00

  • Biventricular myocardial adaptation to different training protocols in competitive master athletes.

    abstract：BACKGROUND:Conflicting data have been reported about the nature (physiologic versus pathologic) of left ventricular (LV) hypertrophy in master athletes. AIM OF THE STUDY:To analyze LV and right ventricular (RV) myocardial function in master athletes with LV hypertrophy induced by either endurance or strength training....

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.03.041

    authors： D'Andrea A,Caso P,Scarafile R,Salerno G,De Corato G,Mita C,Di Salvo G,Allocca F,Colonna D,Caprile M,Ascione L,Cuomo S,Calabrò R

    更新日期：2007-02-14 00:00:00

  • Angioplasty of a left anterior descending artery originating from the right sinus of Valsalva (discussion in decision making).

    abstract：:In this case report, we describe a successful percutaneous transluminal coronary angioplasty of an abnormally originating left anterior descending artery from the right sinus of Valsalva. We discuss about the decision making in this rare and challenging case, since there is more than one opinion as to which is the app...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(96)02730-1

    authors： Antonellis J,Kostopoulos K,Margaris N,Kranidis A,Patsilinakos S,Hitiris C,Salahas A,Tavernarakis A

    更新日期：1996-09-01 00:00:00

  • Can the site of origin of ventricular extrasystoles enhance the localisation of exercise-induced ischaemia?

    abstract：:Previous work from the Departments of Cardiology and Nuclear Medicine, Guy's Hospital, London, has enabled an atlas of the electrocardiographic appearances of ectopics from individual ventricular sites to be compiled. This has been used to investigate the relationship between regions of myocardial ischaemia and the si...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(86)90143-9

    authors： Holt P,Brennand-Roper D,Curry PV,Maisey MN

    更新日期：1986-11-01 00:00:00

  • Chronic medication intake in patients with stable coronary heart disease across Europe: Evidence from the daily clinical practice. Results from the ESC EORP European Survey of Cardiovascular Disease Prevention and Diabetes (EUROASPIRE IV) Registry.

    abstract：BACKGROUND:As advised by the European guidelines on cardiovascular prevention, medication intake is a major component of secondary prevention. The aim of this study is to provide an in-depth overview of the medication intake in stable European coronary heart disease (CHD) patients. METHODS:Analyses are based on the EU...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.09.015

    authors： De Smedt D,De Backer T,Petrovic M,De Backer G,Wood D,Kotseva K,De Bacquer D

    更新日期：2020-02-01 00:00:00

  • Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients.

    abstract：:Fifteen patients with uncomplicated mild to moderate primary hypertension (7 males, 8 females, age range 36-65 years) were submitted to a double blind randomized crossover study, receiving MgO 3 times a day at a daily dose of 1.0 g (600 mg/day of magnesium) and placebo for a period of 6 weeks. This was to test the eff...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0167-5273(96)02716-7

    authors： Sanjuliani AF,de Abreu Fagundes VG,Francischetti EA

    更新日期：1996-10-11 00:00:00

  • Impact of symptomatic atherosclerosis in patients with pulmonary embolism.

    abstract：BACKGROUND:Atherosclerosis is associated with increased cardiovascular mortality. Associations between venous thromboembolism and atherosclerosis were recently reported. We aimed to investigate the impact of symptomatic atherosclerosis on adverse outcomes in patients with pulmonary embolism (PE) and to identify signifi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.12.019

    authors： Keller K,Hobohm L,Münzel T,Ostad MA

    更新日期：2019-03-01 00:00:00

  • Relevance of simultaneous ST segment elevation and depression in an exercise treadmill test.

    abstract：:Simultaneous ST segment elevation and depression recorded during an exercise treadmill test and its correlation with coronary angiogram is a new finding that does not find a place in medical literature. We conclude that in the presence of simultaneous ST segment elevation and ST segment depression during exercise trea...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/s0167-5273(01)00469-7

    authors： Prabhakar D,Vaidiyanathan D

    更新日期：2001-08-01 00:00:00

  • Calcium: A predictor of interventional treatment failure across all fields of cardiovascular medicine.

    abstract：:In this substudy of the ADAPT-DES trial Généreux et al. compared two years outcomes according to the presence or absence of coronary artery calcification (CAC) as assessed by coronary angiography. Coronary calcification was an independent predictor of interventional treatment failure and a higher incidence of both isc...

    journal_title：International journal of cardiology

    pub_type： 社论

    doi：10.1016/j.ijcard.2017.01.054

    authors： Mattesini A,Di Mario C

    更新日期：2017-03-15 00:00:00