Can the site of origin of ventricular extrasystoles enhance the localisation of exercise-induced ischaemia?

Abstract:

:Previous work from the Departments of Cardiology and Nuclear Medicine, Guy's Hospital, London, has enabled an atlas of the electrocardiographic appearances of ectopics from individual ventricular sites to be compiled. This has been used to investigate the relationship between regions of myocardial ischaemia and the site of origin of exercise-induced ventricular arrhythmias. Two hundred and ten patients underwent maximal exercise testing on a bicycle ergometer, prior to thallium scintigraphy. All 12 leads of the electrocardiogram were recorded simultaneously at rest, immediately post-exercise and then for several minutes afterwards. Thallium scintigraphy was performed immediately and 4 hours post-exercise. Twenty-nine patients of the 210 had ventricular arrhythmias on exercise. Two had dilated (congestive) cardiomyopathy, 1 had hypertrophic cardiomyopathy and 26 were subsequently proven to have ischaemic heart disease. Fifteen of those patients with coronary artery disease and ventricular arrhythmias had otherwise negative exercise tests. Patients with reversible posterior (circumflex) defects had right bundle branch block extrasystoles with a limb lead QRS axis of -60 degrees to -150 degrees. Reversible inferior defects demonstrated ectopic activity with left bundle branch block and a superior axis. Ectopics of septal origin could present with either right or left bundle branch block and an inferior axis from the upper septum, or superior axis from the lower septum. In patients with ischaemic heart disease the 12-lead electrocardiographic appearance of ventricular arrhythmias enables their site of origin to be localised thus suggesting ischaemia in a particular coronary artery territory.

journal_name

Int J Cardiol

authors

Holt P,Brennand-Roper D,Curry PV,Maisey MN

doi

10.1016/0167-5273(86)90143-9

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

185-200

issue

2

eissn

0167-5273

issn

1874-1754

pii

0167-5273(86)90143-9

journal_volume

13

pub_type

杂志文章
  • Phase differences between left ventricular wall motion and transmitral flow in man: evidence for involvement of ventricular restoring forces in normal rapid filling.

    abstract::To assess the possible role of restoring forces underlying left ventricular wall motion during rapid filling, the time relations between left ventricular dimensions and filling velocity were studied by digitised M-mode and Doppler echocardiography in 23 normal children and 43 patients: 11 with mild and 17 with severe ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(89)90014-4

    authors: Park CH,Chow WH,Gibson DG

    更新日期:1989-09-01 00:00:00

  • Understanding the controversy surrounding the correlation between fibrinogen level and prognosis of coronary artery disease-The role of the subtypes of coronary artery disease.

    abstract:BACKGROUND:There is a controversy surrounding the correlation between fibrinogen (Fib) level and prognosis of coronary artery disease (CAD). We try to investigate the role of the subtypes of CAD in this controversy. METHODS:A retrospective analysis was conducted from a single center CAD registered database. 3020 conse...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2016.07.160

    authors: Peng Y,Li YM,Chai H,Zuo ZL,Wang PJ,Gui YY,Huang BT,Liao YB,Xia TL,Huang FY,Liu W,Zhang C,Pu XB,Chen SJ,Chen M,Huang DJ

    更新日期:2016-11-01 00:00:00

  • Sex-related differences in cardiomyopathies.

    abstract::Cardiomyopathies (CMPs) are a heterogeneous group of heart muscle diseases with several different phenotypes defined as myocardial disorders in which the heart muscle is structurally and functionally abnormal in the absence of coronary artery disease, hypertension, valvular heart disease and congenital heart disease s...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2018.10.091

    authors: Pelliccia F,Limongelli G,Autore C,Gimeno-Blanes JR,Basso C,Elliott P

    更新日期:2019-07-01 00:00:00

  • Atrioventricular septal defect: From embryonic development to long-term follow-up.

    abstract::Atrioventricular septal defect (AVSD) covers a spectrum of heart anomalies with a common atrioventricular connection and has an incidence of 4-5.3 per 10.000 live births. About half of the AVSDs occur in patient with Down syndrome. This review provides a bench to bedside overview of AVSD. Developmental aspects, nomenc...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2015.09.081

    authors: Calkoen EE,Hazekamp MG,Blom NA,Elders BB,Gittenberger-de Groot AC,Haak MC,Bartelings MM,Roest AA,Jongbloed MR

    更新日期:2016-01-01 00:00:00

  • Lack of evidence of association between MTHFR C677T polymorphism and congenital heart disease in a TDT study design.

    abstract:INTRODUCTION:Hyperhomocysteinemia is frequently associated with congenital defects of the heart and neural tube. A common missense mutation in the MTHFR gene (C to T substitution at position 677 changing valine to alanine) produces a variant with reduced enzymatic action, resulting in higher plasma levels of homocystei...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2004.10.049

    authors: Pereira AC,Xavier-Neto J,Mesquita SM,Mota GF,Lopes AA,Krieger JE

    更新日期:2005-10-20 00:00:00

  • Enhanced protection against pulmonary hypertension with sildenafil and endothelial progenitor cell in rats.

    abstract:BACKGROUND:Sildenafil and bone marrow-derived endothelial progenitor cells (BMDEPCs) have been shown to ameliorate monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in the rat. We test whether combined sildenafil and BMDEPC treatment exerts additional protection against MCT-induced PAH in rats. METHODS...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2011.05.002

    authors: Sun CK,Lin YC,Yuen CM,Chua S,Chang LT,Sheu JJ,Lee FY,Fu M,Leu S,Yip HK

    更新日期:2012-12-15 00:00:00

  • Clinical features of and effects of angiotensin system antagonists on amiodarone-induced pulmonary toxicity.

    abstract:BACKGROUND:Amiodarone (AMD) is a strong antiarrhythmic drug but has severe side effects such as pulmonary toxicity. There are no indicators or drugs that can prevent the development of amiodarone-induced pulmonary toxicity (AIPT). METHODS:We collected data for 96 consecutive patients treated with AMD and analyzed clin...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2008.11.106

    authors: Nikaido A,Tada T,Nakamura K,Murakami M,Banba K,Nishii N,Fuke S,Nagase S,Sakuragi S,Morita H,Ohe T,Kusano KF

    更新日期:2010-04-30 00:00:00

  • Low-density lipoprotein cholesterol estimation by a new formula--confirmation.

    abstract::Our result supports the reliability of new Anandaraja's formula for low-density lipoprotein estimation in Brazil population. ...

    journal_title:International journal of cardiology

    pub_type: 评论,信件

    doi:10.1016/j.ijcard.2006.07.123

    authors: Gasko R

    更新日期:2007-07-10 00:00:00

  • Electropharmacological effects of sandostatin in human atrial fibers.

    abstract::We studied the actions of sandostatin (0.1-1000 nM), an analogue of somatostatin, on human atrial tissues obtained from hearts of 20 patients undergoing corrective cardiac surgery. In 3 preparations showing fast response action potential in normal [K]0 Tyrode solution, sandostatin induced little effect, even at the hi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(91)90382-y

    authors: Lin CI,Wei J,Cheng KK,Ho LT

    更新日期:1991-06-01 00:00:00

  • Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling: a translational perspective for the cardiologist.

    abstract::Diabetes and heart failure are very prevalent, and affect each other's incidence and severity. Novel therapies to reduce post-myocardial infarction (MI) remodeling that progresses into heart failure are urgently needed, especially in diabetic patients. Clinical studies have suggested that some oral anti-diabetic agent...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2013.10.005

    authors: Yin M,Westenbrink BD,Meissner M,van Gilst WH,de Boer RA

    更新日期:2013-11-30 00:00:00

  • Respiratory muscle dysfunction in congestive heart failure--the role of pulmonary hypertension.

    abstract:BACKGROUND:Inspiratory muscle weakness has been described in patients with congestive heart failure (CHF), and only recently in patients with idiopathic pulmonary arterial hypertension. However, the relationship between pulmonary hemodynamics and respiratory muscle function has not been investigated in patients with CH...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2010.04.006

    authors: Filusch A,Ewert R,Altesellmeier M,Zugck C,Hetzer R,Borst MM,Katus HA,Meyer FJ

    更新日期:2011-07-15 00:00:00

  • Large animal model of acute right ventricular failure with functional tricuspid regurgitation.

    abstract:BACKGROUND:Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHOD...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2018.02.072

    authors: Malinowski M,Proudfoot AG,Eberhart L,Schubert H,Wodarek J,Langholz D,Rausch MK,Timek TA

    更新日期:2018-08-01 00:00:00

  • Aquatic exercise training and stable heart failure: A systematic review and meta-analysis.

    abstract:AIM:A meta-analysis and review of the evidence was conducted to determine the efficacy of aquatic exercise training for individuals with heart failure compared to traditional land-based programmes. METHODS:A systematic search was conducted for studies published prior to March 2014, using MEDLINE, PUBMED, Cochrane Libr...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ijcard.2015.03.095

    authors: Adsett JA,Mudge AM,Morris N,Kuys S,Paratz JD

    更新日期:2015-01-01 00:00:00

  • Five-year changes in cardiac structure and function in patients with rheumatoid arthritis compared with the general population.

    abstract:BACKGROUND:Patients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac struct...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2017.03.108

    authors: Davis JM 3rd,Lin G,Oh JK,Crowson CS,Achenbach SJ,Therneau TM,Matteson EL,Rodeheffer RJ,Gabriel SE

    更新日期:2017-08-01 00:00:00

  • Asynchronous contraction of the 2 ventricles caused by ventricular pacing after a Fontan-type operation in a patient with a biventricular heart.

    abstract::We treated a 6-year-old boy who had polysplenia syndrome and tetralogy of Fallot with a small right ventricle (RV), an atrial septal defect, a hemiazygos connection, and bilateral superior vena cava. Because the RV was too small for a biventricular repair to be performed, the patient underwent a total cavopulmonary sh...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2010.02.067

    authors: Higaki T,Kondo C,Tomimatsu H,Yamamura E,Yamamoto E,Konishi K,Nagashima M,Nakanishi T

    更新日期:2011-08-04 00:00:00

  • Sleep's quality disorders in patients with hypertension and type 2 diabetes mellitus.

    abstract::Sleep is one of the most important factors contributing to health. Although same studies examining the relationship between sleep duration and mortality, has not been fully discussed. We consecutively studied two hundred and fifty Caucasian subjects, normoweight, who were referred for ambulatory blood pressure monitor...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2006.07.213

    authors: Fiorentini A,Valente R,Perciaccante A,Tubani L

    更新日期:2007-01-08 00:00:00

  • Combined sotalol and flecainide given at low dosage in patients with the Wolff-Parkinson-White syndrome.

    abstract::We determined the effects of combined sotalol (160 mg/day) and flecainide (200 mg/day) in 15 patients with the Wolff-Parkinson-White syndrome. After medication given for 3 days, the plasma levels were 0.8 +/- 0.3 micrograms/ml for sotalol and 232 +/- 104 ng/ml for flecainide. Electrophysiologic testing showed complete...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(90)90101-a

    authors: Gössinger HD,Siostrzonek P,Mösslacher H

    更新日期:1990-03-01 00:00:00

  • Review of epidemiology and management of atrial fibrillation in developing countries.

    abstract:BACKGROUND:Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia. In developing countries, AF is a growing public health problem with the epidemiologic transition from communicable to non-communicable diseases. However, relatively little is known about AF in the developing world. The aim of this review...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijcard.2013.01.184

    authors: Nguyen TN,Hilmer SN,Cumming RG

    更新日期:2013-09-10 00:00:00

  • Cardiac effects of exercise rehabilitation in hemodialysis patients.

    abstract::Exercise training has well documented beneficial effects in a variety of cardiac disorders. End stage renal disease patients present many cardiovascular complications and suffer from impaired exercise capacity. No study to date has adequately examined the cardiac responses to exercise training in renal patients on hem...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0167-5273(99)00090-x

    authors: Deligiannis A,Kouidi E,Tassoulas E,Gigis P,Tourkantonis A,Coats A

    更新日期:1999-08-31 00:00:00

  • Calcium channel blocking drugs for chronic, stable angina.

    abstract::The slow channel calcium blocking drugs have been shown to be efficacious in patients with chronic stable angina. They provide effective first alternative therapy to beta-blockers in preventing recurrent episodes of myocardial ischemia in patients who do not tolerate treatment with beta-blocking drugs because of, for ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(82)90002-x

    authors: O'Rourke RA

    更新日期:1982-01-01 00:00:00

  • Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.

    abstract:BACKGROUND:Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ven...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2018.09.024

    authors: Vives-Gilabert Y,Sanz-Sánchez J,Molina P,Cebrián A,Igual B,Calvillo-Batllés P,Domingo D,Millet J,Martínez-Dolz L,Castells F,Zorio E

    更新日期:2019-01-01 00:00:00

  • Coronary risk factors and coronary atheroma burden at severely narrowing segments.

    abstract:BACKGROUND:While only few data exist correlating cardiovascular risk factors with volumetric measurements of coronary atheroma burden in patients with coronary artery disease, a recent report using intravascular ultrasound (IVUS) demonstrated independent predictors of atherosclerotic burden in a native coronary artery ...

    journal_title:International journal of cardiology

    pub_type: 信件

    doi:10.1016/j.ijcard.2006.11.194

    authors: Kaneda H,Kataoka T,Ako J,Honda Y,Yock PG,Fitzgerald PJ

    更新日期:2008-02-20 00:00:00

  • Clinical use of transoesophageal atrial stimulation in terminating ventricular tachycardia.

    abstract::This study was performed to evaluate whether transoesophageal atrial pacing could also stop ventricular tachycardias with low rates and no haemodynamic impairment. Prior to resorting to ventricular endocardial pacing, seven male patients, aged between 15 and 73 years, were treated by transoesophageal atrial pacing for...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/0167-5273(90)90318-y

    authors: Favale S,Minafra F,Amodio G,Tritto M,Massari V,Rizzon P

    更新日期:1990-09-01 00:00:00

  • Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.

    abstract:BACKGROUND:Alterations in coronary vasomotor tone may participate in the pathogenesis of acute myocardial infarction (AMI). Vascular ATP-sensitive K(+) (KATP) channels, formed by Kir6.x/SUR2B, are key regulators of coronary tone and mutations in cardiac (Kir6.2/SUR2A) KATP channels result in heart disease. Here we expl...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2013.04.210

    authors: Smith KJ,Chadburn AJ,Adomaviciene A,Minoretti P,Vignali L,Emanuele E,Tammaro P

    更新日期:2013-10-09 00:00:00

  • The fall and rise of rheumatic fever in the United States: a commentary.

    abstract::After a documented decline in the incidence of acute rheumatic fever in the United States during the past three decades, an apparent resurgence has occurred in the mid-1980s. Although standards of living have continued to improve with concomitant decrease in crowding and easier accessibility to medical care, the preci...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-5273(88)90003-4

    authors: Kaplan EL,Markowitz M

    更新日期:1988-10-01 00:00:00

  • Comparison of outcomes after treatment of in-stent restenosis using newer generation drug-eluting stents versus drug-eluting balloon: Patient-level pooled analysis of Korean Multicenter in-Stent Restenosis Registry.

    abstract:BACKGROUND:Studies comparing the drug-eluting balloon (DEB) with contemporary drug-eluting stent (DES) in the treatment of in-stent restenosis (ISR) have been scarce. We compared that the efficacy and safety of contemporary DES versus DEB in unselected, real world patients of ISR occurred in bare-metal stent or DES. M...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijcard.2016.12.176

    authors: Lee JM,Rhee TM,Hahn JY,Hwang D,Park J,Park KW,Kim HL,Kim SH,Chae IH,Doh JH,Jeon KH,Choi YJ,Park JS,Choi SH,Gwon HC,Koo BK,Alfonso F,Kim HS

    更新日期:2017-03-01 00:00:00

  • Is off-pump coronary artery bypass grafting superior to drug-eluting stents for the treatment of coronary artery disease? A meta-analysis of randomized and nonrandomized studies.

    abstract:BACKGROUND:As drug-eluting stent (DES) has almost overcome the disadvantage of frequent restenosis, off-pump coronary artery bypass grafting (OPCAB) has been introduced to avoid complications of cardiopulmonary bypass. However, which approach may promise better outcomes for patients with coronary artery disease remains...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ijcard.2014.04.182

    authors: Lu D,Nie X,Wan J,He S,Du S,Zhang Z,Wang Z,Wang W

    更新日期:2014-07-01 00:00:00

  • The prevalence of aortic stenosis in the elderly in Iceland and predictions for the coming decades: the AGES-Reykjavík study.

    abstract:AIMS:To evaluate the prevalence of significant aortic valve stenosis (AS) in a randomly selected study population of elderly individuals representing the general population of Iceland. Furthermore, to predict the number of individuals likely to have severe AS in the future. METHODS AND RESULTS:Echocardiography and com...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ijcard.2014.08.053

    authors: Danielsen R,Aspelund T,Harris TB,Gudnason V

    更新日期:2014-10-20 00:00:00

  • Incidence, predictors and outcomes of infective endocarditis in a contemporary adult congenital heart disease population.

    abstract:BACKGROUND:The prevalence of congenital heart disease (CHD) in the adult population is steadily increasing. A substrate of prosthetic material and residual lesions, constantly evolving as surgical techniques change over time, predispose these patients to the potentially devastating complication of infective endocarditi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章

    doi:10.1016/j.ijcard.2017.08.035

    authors: Moore B,Cao J,Kotchetkova I,Celermajer DS

    更新日期:2017-12-15 00:00:00

  • A case of splenic artery aneurysm with Cushing's syndrome.

    abstract::We report here a case of splenic artery aneurysm with Cushing's syndrome. Pregnancy and the increased secretion of cortisol from an adrenal adenoma in Cushing's syndrome may affect the intimal and medial degeneration. Factors other than glucocorticoids may influence the pathological changes. ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0167-5273(96)02608-3

    authors: Yoshitomi Y,Yoshimi H,Yutani C

    更新日期:1996-06-01 00:00:00