Abstract:
:The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The right atrial effective refractory period (ERP) and percentage maximum atrial fragmentation (%MAF) were measured by atrial premature stimulation based on a cycle length of 500 ms. The inter-atrial conduction time (ACT) was measured by burst pacing (120/min) for 30 s. AFT was measured by applying a high-frequency (50 Hz) stimulation for 1 s given at the right atrial appendage. AFT was defined as the lowest intensity of electrical current that could induce atrial fibrillation lasting for more than 30 s. Disopyramide significantly reduced %MAF, and prolonged ERP and ACT. AFT was measured in all patients and the mean AFT was 3.1 +/- 1.7 mA. After the administration of disopyramide, AFT significantly increased to 6.1 +/- 3.6 mA. There was a positive correlation between ERP and AFT, and a negative correlation between %MAF and AFT. No correlation was detected between ACT and AFT. In conclusion, disopyramide increased AFT in the human atrium.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Ishibashi K,Inoue D,Sakai R,Inoue M,Shirayama T,Asayama J,Nakagawa Mdoi
10.1016/0167-5273(95)02467-bsubject
Has Abstractpub_date
1995-11-24 00:00:00pages
177-84issue
2eissn
0167-5273issn
1874-1754pii
016752739502467Bjournal_volume
52pub_type
临床试验,杂志文章abstract:BACKGROUND:While some case-control studies have showed the correlation between the hypertriglyceridemic waist (HTGW) phenotype (increased WC and hypertriglyceridemia) and cardiovascular disease (CVD) events, there are few data regarding this correlation in cohort studies, especially in Asian populations that have a hig...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.177
更新日期:2014-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00251-4
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abstract:BACKGROUND:Aortic pressure waveforms are calculated non-invasively by applying generalized transfer functions (GTF) to tonometric radial pressure waveforms. Input errors mainly during acquisition and calibration of tonometric pressures are "transferred" to aortic pressure calculation. The present study aimed to quantif...
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90228-h
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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更新日期:2016-11-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.02.017
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pub_type: 杂志文章
doi:10.1016/0167-5273(93)90009-6
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journal_title:International journal of cardiology
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pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-12-06 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90053-8
更新日期:1988-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.12.050
更新日期:2008-04-25 00:00:00
abstract::The imbalance of the autonomic nervous function has been shown to contribute to the genesis of ventricular arrhythmias. Power spectral analysis of components of heart rate variability has the potential to quantify the cardiac autonomic tone during ambulatory electrocardiographic recording. We analysed the power spectr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90177-i
更新日期:1993-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2000-08-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2015-10-15 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2010-10-29 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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