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Concurrent alpha 1 adrenergic blockade and angiotensin converting enzyme inhibition in the treatment of congestive heart failure.

Abstract：

:We tested the hypothesis that concurrent inhibition of the renin angiotensin system by enalapril (5 mg) and the sympathetic nervous system by alpha 1 adrenergic blockade (prazosin 1 mg) will be superior to enalapril alone in 17 patients with heart failure on standard therapy, in a single blind, placebo-controlled, randomized parallel group study for 4 weeks. Enalapril alone induced a significant increase in exercise time from 499 +/- 412 s to 707 +/- 608 s (P < 0.05, ANOVA), but the increase induced by the enalapril + prazosin combination was significantly greater (P < 0.025, MANOVA) from 214 +/- 271 to 1007 +/- 784 s as was the increase in creatinine clearance (P < 0.05).

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Ajayi AA,Sofowora GG,Balogun MO

doi

10.1016/s0167-5273(96)02799-4

subject

Has Abstract

pub_date

1996-12-06 00:00:00

pages

173-6

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167527396027994

journal_volume

57

pub_type

临床试验,杂志文章,随机对照试验

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