当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells.

Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells.

Abstract：

BACKGROUND:Beraprost sodium, an orally active prostacyclin analogue, has proved to be beneficial for the patients with primary pulmonary hypertension and obstructive peripheral arterial disease. METHODS:In this study, we examined the effects of BPS on the expression of the VEGF and PAI-1 genes in vascular smooth muscle cells. RESULTS:The mRNA levels for VEGF were increased by BPS in C2/2 cells and cultured rat aortic smooth muscle cells. In contrast, PAI-1 mRNA levels were significantly decreased by BPS. Luciferase assays and mRNA decay assays showed that BPS increases VEGF promoter activity and has no effects on its mRNA stability. Likewise, BPS decreases PAI-1 promoter activity without affecting its mRNA stability. Experiments using various pharmacological inhibitors for protein kinases showed that activation of cAMP-dependent protein kinase (PKA) was involved in BPS-mediated regulation of VEGF and PAI-1 mRNA expression. Overexpression of CREB (cAMP-responsive element binding protein) induces VEGF promoter and reduces PAI-1 promoter activities. CREMepsilon, a dominant negative form of CREB, inhibits BPS-mediated changes in VEGF and PAI-1 promoter activities. While BPS augmented hypoxia-induced VEGF mRNA expression, it blunted hypoxia-induced PAI-1 mRNA expression. CONCLUSION:These results suggest that BPS increases VEGF and decreases PAI-1 gene expression through PKA/CREB-dependent mechanisms in vascular smooth muscle cells. Because these effects are observed more prominently under the hypoxic condition compared to normoxic condition, BPS may have a potential to relieve hypoxia by inducing neovasculization and by reducing thrombosis.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Atsuta H,Uchiyama T,Kanai H,Iso T,Tanaka T,Suga T,Maeno T,Arai M,Nagai R,Kurabayashi M

doi

10.1016/j.ijcard.2007.12.119

subject

Has Abstract

pub_date

2009-03-06 00:00:00

pages

411-8

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(08)00284-2

journal_volume

132

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Long-term outcome after drug-eluting stents implantation: target lesion versus nontarget lesion repeated intervention.

    abstract：:We sought to investigate the relative clinical significance of target and nontarget lesions repeated percutaneous coronary intervention (re-PCI) in patients implanted with drug-eluting stents (DES). Out of 2626 consecutive DES patients, we retrospectively selected 166 (6.3%; 123 males, aged 65±10 years) who had a clin...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.11.049

    authors： Fineschi M,Zacà V,Gori T,Casini S,Sinicropi G,Pierli C

    更新日期：2010-11-19 00:00:00

  • Left anterior descending artery length and coronary atherosclerosis in apical ballooning syndrome (Takotsubo/stress induced cardiomyopathy).

    abstract：BACKGROUND:A proposed etiology of apical ballooning syndrome (ABS) is a spontaneously aborted anterior myocardial infarction (MI) in patients with a long "wrap around" left anterior descending artery (LAD) rather than it being a unique cardiomyopathy. The aim of this study was to evaluate whether patients with ABS have...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.06.018

    authors： Hoyt J,Lerman A,Lennon RJ,Rihal CS,Prasad A

    更新日期：2010-11-05 00:00:00

  • Efficacy of intracoronary administration of a short-acting β-blocker landiolol during reperfusion in pigs.

    abstract：BACKGROUND:Although β-blockers are used to prevent myocardial ischemia/reperfusion injury, the risk of heart failure has limited β-blocker therapy in patients with acute myocardial infarction. This study evaluated efficacy of intracoronary administration of the short-acting β-blocker, landiolol, during reperfusion in p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.07.013

    authors： Park H,Otani H,Oishi C,Fujikawa M,Yamashita K,Okazaki T,Sato D,Ueyama T,Iwasaka J,Yamamoto Y,Iwasaka T

    更新日期：2011-02-03 00:00:00

  • Cycle-ergometry stress testing and use of chronotropic reserve adjustment of ST depression for identification of significant coronary artery disease in clinical practice.

    abstract：:Diagnostic reliability of indexations of peak exercise ST segment depression (DeltaST) for heart rate reserve (HRi) or chronotropic reserve (CR) to identify significant coronary artery disease (CAD) by cycle-ergometer exercise testing has not been evaluated previously. Exercise testing by upright cycle-ergometer (25 W...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.04.035

    authors： Palmieri V,Pezzullo S,Arezzi E,D'Andrea C,Cassese S,Martino S,Celentano A

    更新日期：2008-07-21 00:00:00

  • Spontaneous resolution of neoaneurysm following implantation of a paclitaxel-eluting coronary stent.

    abstract：:We report a case of spontaneous resolution of neoaneurysm of the coronary artery complicating paclitaxel-eluting TAXUS stent implantation in the proximal left anterior descending artery in a 56-year-old female. ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.01.056

    authors： Kim JW,Seo HS,Suh SY,Rha SW,Park CG,Oh DJ

    更新日期：2006-09-20 00:00:00

  • Impact of point-of-care pre-procedure creatinine and eGFR testing in patients with ST segment elevation myocardial infarction undergoing primary PCI: The pilot STATCREAT study.

    abstract：BACKGROUND:Contrast-induced acute kidney injury (CI-AKI) is a recognised complication during primary PCI that affects short and long term prognosis. The aim of this study was to assess the impact of point-of-care (POC) pre-PPCI creatinine and eGFR testing in STEMI patients. METHODS:160 STEMI patients (STATCREAT group)...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.03.147

    authors： Karamasis GV,Hampton-Till J,Al-Janabi F,Mohdnazri S,Parker M,Ioannou A,Jagathesan R,Kabir A,Sayer JW,Robinson NM,Aggarwal RK,Clesham GJ,Gamma RA,Kelly PA,Tang KH,Davies JR,Keeble T

    更新日期：2017-08-01 00:00:00

  • Acute left main occlusion secondary to embolisation from an aortic valve prosthesis: successful treatment with embolectomy and percutaneous coronary intervention.

    abstract：:Acute occlusive embolus of the left main coronary artery is a rare and usually catastrophic occurrence. We present a case report of a 59 year old with an aortic valve prosthesis presenting in cardiogenic shock following cessation of warfarin therapy. Angiography demonstrated an acute left main occlusion secondary to e...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.05.049

    authors： Ranasinghe I,Yiannikas J,Brieger D

    更新日期：2011-06-16 00:00:00

  • Giant right atrial aneurysm: a case report.

    abstract：:Giant right atrial aneurysm is a very rare congenital heart defect. We report a case which was diagnosed during fetal life and operated on at 4 months of age with excision of the aneurysmal part and pericardial patch closure. Early repair is recommended to prevent late complications such as arrhythmias and thromboembo...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.06.081

    authors： Papagiannis J,Chatzis A,Sarris G

    更新日期：2008-09-16 00:00:00

  • Sex-related differences in peri- and post-ablation clinical data for patients with atrial flutter.

    abstract：UNLABELLED:Sex-related differences were not reported for the atrial flutter (AF). The purpose of the study was to look for the influence of gender on indications, clinical data and long-term results of AFl ablation. METHODS:985 patients, [227 females (23%)] were referred for radiofrequency AFl ablation. Clinical histo...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.12.088

    authors： Brembilla-Perrot B,Huttin O,Manenti V,Benichou M,Sellal JM,Zinzius PY,Beurrier D,Schwartz J,Laporte F,de Chillou C,Andronache M,Cismaru G,Pauriah M,Selton O,Louis P,Terrier de la Chaise A

    更新日期：2013-10-03 00:00:00

  • Sterile abscess formation as a complication of hydrophilic radial artery cannulation.

    abstract：:A sterile inflammatory response has been observed at the access site in a small number of patients who have undergone radial artery cannulation with a hydrophilic sheath. This reaction generally appears from several days to weeks after use of the sheath, and while a distinct cause has not been established it is not th...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.06.146

    authors： Tharmaratnam D,Webber S,Owens P

    更新日期：2008-10-30 00:00:00

  • Hypertensive subjects with type-2 diabetes, the sympathetic nervous system, and treatment implications.

    abstract：:Central obesity is closely linked to hypertension and type-2 diabetes (DM2) in young/middle-age. In the elderly, systolic hypertension is a reflection of aging/stiff arteries. Diastolic (± systolic) hypertension in young/middle-age is accompanied by increased sympathetic nerve activity, particularly in the presence of...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2014.04.204

    authors： Coats AJ,Cruickshank JM

    更新日期：2014-07-01 00:00:00

  • Advanced interatrial block is an electrocardiographic marker for recurrence of atrial fibrillation after electrical cardioversion.

    abstract：BACKGROUND:Early recurrence of atrial fibrillation (AF) is common following a successful electrical cardioversion (ECV). The purpose of this study was to investigate the hypothesis that AF recurrence is related to atrial electrical inhomogeneity, which may influence the P wave characteristics. METHODS:Two hundred nine...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.07.135

    authors： Fujimoto Y,Yodogawa K,Maru YJ,Oka E,Hayashi H,Yamamoto T,Iwasaki YK,Hayashi M,Shimizu W

    更新日期：2018-12-01 00:00:00

  • Suppression by propranolol and amiodarone of an electrical storm refractory to metoprolol and amiodarone.

    abstract：:A 60-year-old male patient with ischemic cardiomyopathy experienced an electrical storm 1 month after implantation of an internal cardioverter-defibrillator. Recurrent life-threatening episodes of ventricular tachycardia persisted despite maximal antiarrhythmic theraphy with amiodarone, metoprolol and mexiletine. Afte...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2003.11.033

    authors： Tsagalou EP,Kanakakis J,Rokas S,Anastasiou-Nana MI

    更新日期：2005-03-18 00:00:00

  • Defining the role of palliative care in older adults with heart failure.

    abstract：:While palliative care is often thought of as only being applicable to dying patients, its focus on symptom alleviation, patient function, and quality of life has much to offer older adults with chronic heart failure. Heart failure worsens patients' health status through patients' symptom burden, functional limitations...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2007.10.005

    authors： Bekelman DB,Hutt E,Masoudi FA,Kutner JS,Rumsfeld JS

    更新日期：2008-04-10 00:00:00

  • Multiple interventions following an acute coronary syndrome event increase uptake into cardiac rehabilitation.

    abstract：AIMS:Cardiac rehabilitation (CR) improves morbidity and mortality. Uptake varies for patients following acute coronary syndrome (ACS). Entry into CR is often dependent on the management strategy received, lower following percutaneous coronary intervention (PCI), higher following coronary artery bypass grafting (CABG). ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.11.005

    authors： Lawless M,Harrison AS,Doherty P

    更新日期：2020-11-10 00:00:00

  • A novel polymer-free drug-eluting stent coated with everolimus using nitrogen-doped titanium dioxide film deposition in a porcine coronary restenosis model.

    abstract：BACKGROUND:Titanium dioxide (TiO2) films have superior biocompatibility and may be effective as drug-binding matrices for drug-eluting stents (DESs). We sought to evaluate efficacy of a polymer-free DES coated with everolimus using nitrogen-doped TiO2 film deposition in a porcine coronary restenosis model. METHODS:For...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.07.275

    authors： Sim DS,Jeong MH,Park DS,Kim JH,Lim KS,Bae IH,Zhehao P,Yang HY,Lee JH,Hyun DY,Hong YJ,Kim JH,Ahn Y,Kang JC

    更新日期：2016-11-01 00:00:00

  • Effect of diltiazem on norepinephrine-induced acute left ventricular dysfunction.

    abstract：:The present study has examined the role of diltiazem as a protective agent in a canine model of norepinephrine cardiotoxicity. Effects of diltiazem, 20 micrograms/kg/min x 5 min pretreatment followed by 10 micrograms/kg/min x 90 min, or saline infusion were examined at baseline and 1 h after infusion of norepinephrine...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(92)90105-c

    authors： Jolly SR,Reeves WC,Mozingo S,Mehta P,Gilliland MG,Wilson E,Movahed A

    更新日期：1992-07-01 00:00:00

  • False tendons may be associated with the genesis of J-waves: prospective study in young healthy male.

    abstract：BACKGROUND:Recent studies showed that J-waves are associated with vulnerability to ventricular fibrillation. Recently we reported the association between false tendons (FTs) and J-waves in a retrospective study. METHODS AND RESULTS:We prospectively studied 50 young healthy men (mean age 24.6±2.7 years). FTs were detec...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.01.101

    authors： Nakagawa M,Ezaki K,Miyazaki H,Ebata Y,Shinohara T,Teshima Y,Yufu K,Takahashi N,Saikawa T

    更新日期：2014-03-15 00:00:00

  • Primary malignant pericardial sarcoma.

    abstract：:We describe the case of a 91-year-old man who presented with a large pericardial effusion and an intrapericardial mass. Primary malignant pericardial sarcoma was diagnosed by percutaneous pericardial tumor biopsy. The patient died of multiple organ failure three months later. We also review the epidemiology, clinical ...

    journal_title：International journal of cardiology

    pub_type： 信件,评审

    doi：10.1016/j.ijcard.2008.03.097

    authors： Zhengrong W,Yun Z,Fuchun Z

    更新日期：2009-07-24 00:00:00

  • Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction.

    abstract：OBJECTIVE:To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. METHODS:After a 1-week washout period, the patients were ra...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2004.03.040

    authors： Zaliūnas R,Brazdzionyte J,Zabiela V,Jurkevicius R

    更新日期：2005-06-08 00:00:00

  • An assessment of the reporting quality of randomised controlled trials relating to anti-arrhythmic agents (2002-2011).

    abstract：BACKGROUND:Despite being the gold-standard for investigations, randomised controlled trials can deliver biased results if methodology is flawed. The CONSORT statements are intended to guide the reporting of trials. We assessed the reporting quality of anti-arrhythmic drug trials over the last decade. METHODS:Medline a...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2012.12.020

    authors： Camm CF,Chen Y,Sunderland N,Nagendran M,Maruthappu M,Camm AJ

    更新日期：2013-09-30 00:00:00

  • Sex and age differences and outcomes in acute coronary syndromes.

    abstract：BACKGROUND:There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with AC...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijcard.2016.06.217

    authors： Vasiljevic-Pokrajcic Z,Mickovski N,Davidovic G,Asanin M,Stefanovic B,Krljanac G,Radosavljevic-Radovanovic M,Radovanovic N,Lasica R,Milanović S,Bjekić J,Majstorovic-Stakic M,Trifunovic D,Karadzic A,Rajic D,Milosevic A,Zdra

    更新日期：2016-08-01 00:00:00

  • Calcium antagonists and atherosclerosis.

    abstract：:Calcium channel blockers (CCBs) have several properties which may have beneficial effects on the development of atherosclerosis. These include inhibition of vascular smooth muscle cell (SMC) proliferation and migration; inhibition of calcium influx into the vascular wall; reduction of extracellular matrix synthesis; p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0167-5273(97)00236-2

    authors： Schachter M

    更新日期：1997-12-31 00:00:00

  • Electromechanical delay by speckle-tracking echocardiography: A novel tool to distinguish between Brugada syndrome and isolated right bundle branch block.

    abstract：BACKGROUND:The electrocardiographic (ECG) definition of Brugada syndrome (BS) can be challenging because benign ECG abnormalities, such as right bundle branch block (RBBB), may mimic pathological ECG characteristics of BrS. However, although myocardial delay and deformation can be quantified by advanced imaging, it has...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.06.029

    authors： D'Ascenzi F,Sanz-De La Garza M,Anselmi F,Nunno L,Arbelo E,Jordà P,Marzotti T,Aprile F,Piu P,Natali BM,Brugada J,Sitges M,Mondillo S

    更新日期：2020-12-01 00:00:00

  • Both levosimendan and dobutamine treatments result in significant reduction of NT-proBNP levels, but levosimendan has better and prolonged neurohormonal effects than dobutamine.

    abstract：:Levosimendan and dobutamine are comparable inotropic drugs as regards their hemodynamic effects and clinical outcomes in decompensated heart failure (HF). The aim of this study was to compare the effects of levosimendan and dobutamine treatment on NT-proBNP levels in patients with decompensated HF. Forty-four patients...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.06.136

    authors： Cavusoglu Y,Tek M,Birdane A,Ata N,Demirustu C,Gorenek B,Unalir A,Timuralp B

    更新日期：2008-07-21 00:00:00

  • PARP inhibition and postinfarction myocardial remodeling.

    abstract：:Coronary artery disease accounts for the greatest proportion of cardiovascular diseases therefore it is the major cause of death worldwide. Its therapeutic importance is indicated by still high mortality of myocardial infarction, which is one of the most severe forms of CVDs. Moreover, the risk of developing heart fai...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.06.223

    authors： Halmosi R,Deres L,Gal R,Eros K,Sumegi B,Toth K

    更新日期：2016-08-01 00:00:00

  • Differential prognosis of vasospastic angina according to presentation with sudden cardiac arrest or not: Analysis of the Korean Health Insurance Review and Assessment Service.

    abstract：BACKGROUND:The long-term prognosis of vasospastic angina (VSA) patients presenting with aborted sudden cardiac death (ASCD) is still unknown. We sought to compare the long-term clinical outcomes between VSA patients presenting with and without ASCD by retrospective analysis of a nationwide population-based database. M...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.09.082

    authors： Park TK,Gwag HB,Park SJ,Park H,Kang D,Park J,Cho J,Chung CR,Jeon K,Suh GY,Guallar E,Cho J,Yang JH

    更新日期：2018-12-15 00:00:00

  • Direction, location, and size of shunt flow in congenital heart disease evaluated by ECG-gated multislice computed tomography.

    abstract：OBJECTIVE:To demonstrate the utility of multislice computed tomography (MSCT) in the evaluation of direction, location, and size of shunt flow in congenital heart disease. BACKGROUND:Transthoracic and transesophageal echocardiography, magnetic resonance imaging, and conventional angiography has been used to evaluate c...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2005.07.078

    authors： Funabashi N,Asano M,Sekine T,Nakayama T,Komuro I

    更新日期：2006-10-10 00:00:00

  • Incidence of atrial fibrillation in an Italian population followed by their GPs through a telecardiology service.

    abstract：BACKGROUND:Atrial fibrillation (AF) is the most common sustained cardiac tachyarrhythmia and is often an occasional diagnosis in the absence of known cardiac disease. The aim of this study is to describe an Italian patient population with AF followed by their General Practitioners (GPs) using a telecardiology service. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2003.12.005

    authors： Scalvini S,Piepoli M,Zanelli E,Volterrani M,Giordano A,Glisenti F

    更新日期：2005-02-15 00:00:00

  • TGFβ1 contributes to cardiomyogenic-like differentiation of human bone marrow mesenchymal stem cells.

    abstract：BACKGROUND:The majority of the protocols for cardiomyocyte differentiation of MSC use 5-azacytidine as an inducer. As transforming growth factor β1 and 5-azacytidine share similar target signaling pathways, we examined whether transforming growth factor β1 can play a role in cardiac differentiation process in human mes...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2011.08.003

    authors： Mohanty S,Bose S,Jain KG,Bhargava B,Airan B

    更新日期：2013-02-10 00:00:00