Abstract:
BACKGROUND:Only a few studies have investigated the prospective relationship between insulin-like growth factor binding protein-1 (IGFBP-1) and cardiovascular events and the results are conflicting. METHODS:In this prospective cohort study, we followed both cases, i.e. survivors of a first acute myocardial infarction (AMI) and their age, sex and hospital catchment area matched controls of a large population-based case-control study for 8 years for total and cardiac mortality, AMI, stroke and hospitalization for heart failure (HF). Levels of IGFBP-1 were measured three months after AMI in a stable metabolic phase in 853 patients. For 1106 control subjects, the time of measurement was as close as possible to that of 'his/her' case. Established cardiovascular risk and prognostic factors were also determined. RESULTS:Higher IGFBP-1 values predicted hospitalization for HF during follow-up both in the patient and the control cohort. Control subjects with higher IGFBP-1 values had elevated mortality when compared to those with the lowest quartile. The associations between IGFBP-1 and other outcomes investigated in this study, i.e. mortality among patients, AMI or stroke among patients and controls were weak and statistically not significant. CONCLUSIONS:Levels of IGFBP-1 consistently predicted HF both among survivors of a first AMI and their matched controls. Our results suggest that IGFBP-1 levels might also predict mortality in a population free of previous AMI.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Janszky I,Hallqvist J,Ljung R,Hammar Ndoi
10.1016/j.ijcard.2008.08.003subject
Has Abstractpub_date
2010-01-07 00:00:00pages
50-5issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(08)00947-9journal_volume
138pub_type
杂志文章abstract:BACKGROUND:The lack of an accurate noninvasive method for assessing right ventricular (RV) volume and function has been a major deficiency of two-dimensional (2D) echocardiography. The aim of our study was to test the feasibility of single-beat full-volume capture with real-time three-dimensional echo (3DE) imaging sys...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 信件
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pub_type: 杂志文章
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pub_type: 信件
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pub_type: 信件
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