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Does Googling lead to statin intolerance?

Abstract：

BACKGROUND:The nocebo effect, where patients with expectations of adverse effects are more likely to experience them, may contribute to the high rate of statin intolerance found in observational studies. Information that patients read on the internet may be a precipitant of this effect. The objective of the study was to establish whether the number of websites about statin side effects found using Google is associated with the prevalence of statin intolerance. METHODS:The prevalence of statin intolerance in 13 countries across 5 continents was established in a recent study via a web-based survey of primary care physicians and specialists. Using the Google search engine for each country, the number of websites about statin side effects was determined, and standardized to the number of websites about statins overall. Searches were restricted to pages in the native language, and were conducted after connecting to each country using a virtual private network (VPN). RESULTS:English-speaking countries (Australia, Canada, UK, USA) had the highest prevalence of statin intolerance and also had the largest standardized number of websites about statin side effects. The sample Pearson correlation coefficient between these two variables was 0.868. CONCLUSIONS:Countries where patients using Google are more likely to find websites about statin side effects have greater levels of statin intolerance. The nocebo effect driven by online information may be contributing to statin intolerance.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Khan S,Holbrook A,Shah BR

doi

10.1016/j.ijcard.2018.02.085

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

25-27

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)36599-3

journal_volume

262

pub_type

杂志文章,多中心研究

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