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Transmission of calibration errors (input) by generalized transfer functions to the aortic pressures (output) at different hemodynamic states.

Abstract：

BACKGROUND:Aortic pressure waveforms are calculated non-invasively by applying generalized transfer functions (GTF) to tonometric radial pressure waveforms. Input errors mainly during acquisition and calibration of tonometric pressures are "transferred" to aortic pressure calculation. The present study aimed to quantify the proportion of specific input errors which is "transferred" by the GTFs in a wide range of hemodynamic conditions and for different error combinations in brachial systolic (SBP) and diastolic (DBP) blood pressure measurements. METHODS:Aortic pulse wave analysis was performed in 103 subjects (52 normotensive and 51 untreated hypertensive) by the SphygmoCor System. Each pressure waveform was initially calibrated by sphygmomanometrical brachial pressures. Isolated, parallel and reverse errors in brachial SBP/DBP from -10 to +10 mmHg were simulated, by recalibration of the recorded radial pressure waveforms, inducing specific "errors" of GTF-input values. For every recalculated aortic SBP and DBP, the difference from the initial estimated value was considered to represent the "transferred error" to the aortic pressure estimation. RESULTS:Parallel errors by +/-5 mmHg in both SBP and DBP resulted to an identical change in GTF-derived aortic pressures, as expected. When an overestimation in SBP by 5 mmHg and an underestimation in DBP by -5 mmHg occurred (reverse errors), almost 56% of this error (approximately 2.8 mmHg) was transferred. An isolated error in brachial SBP by +/-5 mmHg was transmitted by 76% ( approximately 3.8 mmHg) to GTF-derived aortic SBP. In subjects with mean blood pressure>117 mmHg or with heart rates<74 bpm, a greater percent of the calibration error was transferred to GTF-derived blood pressures. CONCLUSIONS:Input errors in brachial pressure values result in a quantifiable effect on transfer function output (aortic pressures). The percent of the "error transfer" by the GTFs depends on heart rate and BP levels, which should be taken into account when applying GTFs at populations with different hemodynamic conditions.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Papaioannou TG,Lekakis JP,Karatzis EN,Papamichael CM,Stamatelopoulos KS,Protogerou AD,Mavrikakis M,Stefanadis C

doi

10.1016/j.ijcard.2005.07.014

subject

Has Abstract

pub_date

2006-06-07 00:00:00

pages

46-52

issue

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(05)01023-5

journal_volume

110

pub_type

杂志文章

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Transmission of calibration errors (input) by generalized transfer functions to the aortic pressures (output) at different hemodynamic states.