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Increased levels of C-reactive protein and fibrinogen influence the risk of vascular events in patients with NIDDM.

Abstract：

AIM:To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS:We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death. RESULTS:During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events. CONCLUSION:Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Coppola G,Corrado E,Muratori I,Tantillo R,Vitale G,Lo Coco L,Novo S

doi

10.1016/j.ijcard.2004.12.051

subject

Has Abstract

pub_date

2006-01-04 00:00:00

pages

16-20

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(05)00302-5

journal_volume

106

pub_type

杂志文章

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