Increased levels of C-reactive protein and fibrinogen influence the risk of vascular events in patients with NIDDM.


AIM:To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS:We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death. RESULTS:During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events. CONCLUSION:Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.


Int J Cardiol


Coppola G,Corrado E,Muratori I,Tantillo R,Vitale G,Lo Coco L,Novo S




Has Abstract


2006-01-04 00:00:00














  • Extracranial carotid artery stenosis and outcomes of patients undergoing transcatheter aortic valve replacement.

    abstract:BACKGROUND:Transcatheter aortic valve replacement (TAVR) is an alternative to open cardiac surgery in selected patients with severe aortic stenosis (AS). Carotid artery stenosis (CAS) has been associated with an increased risk of stroke following cardiac surgery, although the association between CAS and outcomes follow...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ben-Shoshan J,Zahler D,Steinvil A,Banai S,Keren G,Bornstein NM,Finkelstein A,Halkin A

    更新日期:2017-01-15 00:00:00

  • Comparison of prognostic variables in children and adults with Fontan circulation.

    abstract:BACKGROUND:Non-cardiac complications, such as hepato-renal and metabolic problems, are emerging late after the Fontan operation due to its unique hemodynamics. Consequently, associations between clinical variables and postoperative outcome may change during the prolonged postoperative course. METHODS AND RESULTS:To de...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ohuchi H,Yasuda K,Miyazaki A,Iwasa T,Sakaguchi H,Shin O,Mizuno M,Negishi J,Noritake K,Yamada O

    更新日期:2014-05-01 00:00:00

  • Macroscopic assessment of porcine coronary vessel wall trauma after percutaneous cardiac catheterization and intervention.

    abstract::A macroscopic pathological assessment of the coronary arteries of a pig's heart, in which stent implantation and intra-vascular ultrasound and thermography pullbacks were performed, shows that during percutaneous coronary catheterization and intervention, one of the major vessel traumas occurs in the very proximal par...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Agostoni P,Borenstein N,Verheye S,Van Langenhove G

    更新日期:2006-11-18 00:00:00

  • Cost-utility analysis of add-on dapagliflozin treatment in heart failure with reduced ejection fraction.

    abstract:BACKGROUND:Dapagliflozin is an antidiabetic medication that has been shown to reduce the risk of heart failure hospitalization and cardiovascular death in patients with heart failure with reduced ejection fraction (HFrEF). This study aimed to determine the cost-utility of add-on dapagliflozin treatment for HFrEF. METH...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Krittayaphong R,Permsuwan U

    更新日期:2021-01-01 00:00:00

  • Impact of race on morbidity and mortality in patients with congestive heart failure: a study of the multiracial population in Singapore.

    abstract:AIM:We assessed the impact of race on clinical outcome in the multiracial Singapore congestive heart failure (CHF) population. METHODS:668 CHF patients (Age 66+/-12 years, Ejection fraction 29+/-13%), consisting of Chinese (72%), Malays (17.1%) and Indians (10.9%) were prospectively followed up for 24+/-12 months. Pri...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Lee R,Chan SP,Chan YH,Wong J,Lau D,Ng K

    更新日期:2009-05-29 00:00:00

  • The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease.

    abstract:OBJECTIVES:Our objective was to investigate the actual incidence and clinical determinants of cough leading to discontinuation of ACE-inhibitors. Cough is the most frequent reason to stop ACE-inhibitor treatment. METHODS:We studied 27,492 ACE-inhibitor naïve patients randomized to the ACE-inhibitor perindopril or plac...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Brugts JJ,Arima H,Remme W,Bertrand M,Ferrari R,Fox K,DiNicolantonio J,MacMahon S,Chalmers J,Zijlstra F,Caliskan K,Simoons ML,Mourad JJ,Boersma E,Akkerhuis KM

    更新日期:2014-10-20 00:00:00

  • Relevance of simultaneous ST segment elevation and depression in an exercise treadmill test.

    abstract::Simultaneous ST segment elevation and depression recorded during an exercise treadmill test and its correlation with coronary angiogram is a new finding that does not find a place in medical literature. We conclude that in the presence of simultaneous ST segment elevation and ST segment depression during exercise trea...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Prabhakar D,Vaidiyanathan D

    更新日期:2001-08-01 00:00:00

  • Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction.

    abstract:BACKGROUNDS:Nitroglycerine-induced vasodilation (NID) is usually assessed as a control test for flow-mediated vasodilation (FMD). However, NID per se is impaired in patients with high cardiovascular risk. The purpose of this study was to investigate the associations of chronic kidney disease (CKD) with NID and FMD. ME...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Iwamoto Y,Maruhashi T,Kajikawa M,Oda N,Kishimoto S,Matsui S,Hashimoto H,Aibara Y,Yusoff FM,Hidaka T,Kihara Y,Chayama K,Noma K,Nakashima A,Goto C,Higashi Y

    更新日期:2018-03-01 00:00:00

  • Feasibility and safety of Reveal LINQ insertion in a sterile procedure room versus electrophysiology laboratory.

    abstract:BACKGROUND:Insertable cardiac monitors (ICMs) are increasingly utilized for diagnosis of unexplained syncope and arrhythmia monitoring. The Reveal LINQ is a novel miniaturized ICM with improved algorithms. The feasibility and safety of insertion outside the traditional electrophysiology laboratory is unknown. Here we c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Wong GR,Lau DH,Middeldorp ME,Harrington JA,Stolcman S,Wilson L,Twomey DJ,Kumar S,Munawar DA,Khokhar KB,Mahajan R,Sanders P

    更新日期:2016-11-15 00:00:00

  • Sudden cardiac death associated with a coronary artery anomaly considered benign.

    abstract::Separate origin of the left anterior descending and circumflex coronary artery from the left sinus of Valsalva is one of the most frequent benign coronary artery anomalies. We hereby report, for the first time, a case of sudden death in a young man with this anomaly. The clinicopathologic findings and the possible pat...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Cittadini F,Oliva A,Arena V,Senati M,Pascali VL

    更新日期:2009-03-20 00:00:00

  • Diagnostic performance of stress perfusion cardiac magnetic resonance for the detection of coronary artery disease: A systematic review and meta-analysis.

    abstract:INTRODUCTION:The purpose of this study was to investigate the accuracy of qualitative stress perfusion cardiac magnetic resonance (CMR) to diagnose ischemia-causing lesions according to different definitions of significant coronary artery disease (CAD), and magnetic field strength. METHODS:We searched PubMed, Web of S...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Kiaos A,Tziatzios I,Hadjimiltiades S,Karvounis C,Karamitsos TD

    更新日期:2018-02-01 00:00:00

  • Cell therapy prevents structural, functional and molecular remodeling of remote non-infarcted myocardium.

    abstract:BACKGROUND/OBJECTIVES:Therapy using bone marrow (BM) cells has been tested experimentally and clinically due to the potential ability to restore cardiac function by regenerating lost myocytes or increasing the survival of tissues at risk after myocardial infarction (MI). In this study we aimed to evaluate whether BM-de...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: dos Santos L,Gonçalves GA,Davel AP,Santos AA,Krieger JE,Rossoni LV,Tucci PJ

    更新日期:2013-10-09 00:00:00

  • Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers reduced dementia risk in patients with diabetes mellitus and hypertension.

    abstract:OBJECTIVE:The effects of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) on dementia risk in patients with type 2 diabetes mellitus (DM) and hypertension remain unknown. We investigated the effects of ACEIs and ARBs on dementia risk in patients with type 2 DM and hypertension....

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Kuan YC,Huang KW,Yen DJ,Hu CJ,Lin CL,Kao CH

    更新日期:2016-10-01 00:00:00

  • Raised leptin concentrations among South Asian patients with chronic heart failure.

    abstract:BACKGROUND:The disease presentation of chronic heart failure (CHF) is considered to progress with metabolic deterioration, underlined by changes in adipose associated hormones (adipocytokines). However, little is known about ethnic variations of adipocytokines amongst CHF patients, in particular South Asians, who are a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Patel JV,Sosin M,Lim HS,Chung I,Panja N,Davis RC,Hughes EA,Lip GY

    更新日期:2007-10-31 00:00:00

  • The role of red blood cells in the progression and instability of atherosclerotic plaque.

    abstract::This review attempts to present a focused summary of selected areas of the rapidly growing knowledge regarding the red blood cells role in atherosclerotic plaque progression and instability. A summary of the characteristics of the erythrocyte membranes is provided, followed by a brief review of the in vitro and in viv...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Tziakas DN,Chalikias GK,Stakos D,Boudoulas H

    更新日期:2010-06-25 00:00:00

  • Clinical and invasive 7-month follow-up of a patient with a synthetic coronary graft.

    abstract::The PossisR polytetrafluoroethylene Permaflow is a synthetic coronary graft which incorporates a Venturi resistor and which is anastomosed to the superior vena cava. Multiple anastomoses to the coronary vessels can be established in sequence until the graft is finally connected to the aorta. This aortocaval fistula en...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Kerber S,Baumbach M,Rahmel A,Weyand M,Scheld HH,Breithardt G

    更新日期:1995-09-01 00:00:00

  • A new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points.

    abstract:BACKGROUND:Modern randomised controlled trials typically use composite endpoints. This is only valid if each endpoint is equally important to patients but few trials document patient preference and seek the relative importance of components of combined endpoints. If patients weigh endpoints differentially, our interpre...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析


    authors: Ahmad Y,Nijjer S,Cook CM,El-Harasis M,Graby J,Petraco R,Kotecha T,Baker CS,Malik IS,Bellamy MF,Sethi A,Mikhail GW,Al-Bustami M,Khan M,Kaprielian R,Foale RA,Mayet J,Davies JE,Francis DP,Sen S

    更新日期:2015-09-15 00:00:00

  • Myocardial ischemia: From disease to syndrome.

    abstract::Although current guidelines on the management of stable coronary artery disease acknowledge that multiple mechanisms may precipitate myocardial ischemia, recommended diagnostic, prognostic and therapeutic algorithms are still focused on obstructive epicardial atherosclerotic lesions, and little progress has been made ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Marzilli M,Crea F,Morrone D,Bonow RO,Brown DL,Camici PG,Chilian WM,DeMaria A,Guarini G,Huqi A,Merz CNB,Pepine C,Scali MC,Weintraub WS,Boden WE

    更新日期:2020-09-01 00:00:00

  • Left ventricular function response to exercise in normotensive obese subjects: influence of degree and duration of obesity.

    abstract::This study has been designed to evaluate whether duration and severity of obesity can influence left ventricular function response to exercise in obese subjects without other known cardiovascular risk factors such as hypertension, diabetes or hyperlipoproteinemia. A total of 29 obese subjects were included and they we...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Licata G,Scaglione R,Paterna S,Parrinello G,Indovina A,Dichiara MA,Alaimo G,Merlino G

    更新日期:1992-11-01 00:00:00

  • Heart rate as a prognostic marker and therapeutic target in acute and chronic heart failure.

    abstract::Since increased heart rate (HR) is associated with higher mortality in several cardiac disorders, HR is considered not only a physiological indicator but also a prognostic and biological marker. In heart failure (HF), it represents a therapeutic target in chronic phase. The use or up-titration of beta-blockers, a mile...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Oliva F,Sormani P,Contri R,Campana C,Carubelli V,Cirò A,Morandi F,Di Tano G,Mortara A,Senni M,Metra M,Ammirati E

    更新日期:2018-02-15 00:00:00

  • The influence of early intervention in acute myocardial infarction on long-term mortality and morbidity as assessed in the Göteborg metoprolol trial.

    abstract::The mortality and morbidity were assessed during a 2-year follow-up in an acute intervention trial in suspected acute myocardial infarction with metoprolol (a selective beta 1-blocker). On admission to the trial, the 1395 participating patients were randomly allocated to metoprolol or placebo for 3 months. Thereafter,...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Herlitz J,Hjalmarson A,Swedberg K,Vedin A,Waagstein F,Waldenström A,Wilhelmsson C

    更新日期:1986-03-01 00:00:00

  • SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy.

    abstract:BACKGROUND:Doxorubicin (DOXO) is an effective anti-neoplastic drug but its clinical benefits are hampered by cardiotoxicity. Oxidative stress, apoptosis and myocardial fibrosis mediate the anthracycline cardiomyopathy. ROS trigger TGF-β pathway that activates cardiac fibroblasts promoting fibrosis. Myocardial stiffness...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Cappetta D,Esposito G,Piegari E,Russo R,Ciuffreda LP,Rivellino A,Berrino L,Rossi F,De Angelis A,Urbanek K

    更新日期:2016-02-15 00:00:00

  • Multimodal assessment of vascular and ventricular function in children and adults with repaired aortic coarctation.

    abstract:BACKGROUND:Coarctation of the Aorta (CoA) is associated with increased aortic stiffness and diastolic left ventricular dysfunction. The mechanisms involved and impact of age remain unclear. It was the aim of this study to characterize arterial and cardiac function, their correlation, and the effect of age in children a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Weismann CG,Maretic A,Grell BS,Åkesson A,Hlebowicz J,Liuba P

    更新日期:2021-01-15 00:00:00

  • Is off-pump coronary artery bypass grafting superior to drug-eluting stents for the treatment of coronary artery disease? A meta-analysis of randomized and nonrandomized studies.

    abstract:BACKGROUND:As drug-eluting stent (DES) has almost overcome the disadvantage of frequent restenosis, off-pump coronary artery bypass grafting (OPCAB) has been introduced to avoid complications of cardiopulmonary bypass. However, which approach may promise better outcomes for patients with coronary artery disease remains...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析


    authors: Lu D,Nie X,Wan J,He S,Du S,Zhang Z,Wang Z,Wang W

    更新日期:2014-07-01 00:00:00

  • High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation.

    abstract:BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to compare the atrial proteome of subjects with AF versus controls with sinus rhythm (SR). Our aim was to identify novel...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: García A,Eiras S,Parguiña AF,Alonso J,Rosa I,Salgado-Somoza A,Rico TY,Teijeira-Fernández E,González-Juanatey JR

    更新日期:2011-08-04 00:00:00

  • Implications for single phase prospective CT coronary angiography for the diagnosis of significant coronary stenoses in clinical practice.

    abstract:BACKGROUND:CT coronary angiography (CTA) with 64 slice multi-detector CT (64-MDCT) has assumed an increasing role in clinical practice; however the high radiation dose associated with retrospective ECG-gated CTA has led to suggestions that a low dose prospectively gated strategy may be more appropriate. This study aims...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Sá MI,Nicol ED,Stirrup J,Crean A,Roughton M,Padley SP,Rubens MB

    更新日期:2011-03-17 00:00:00

  • Depression of lymphocyte reactivity by serum from patients with dilated cardiomyopathy.

    abstract::We have investigated the presence of serum factors (serum inhibitory factor and rosette inhibitory factor) which inhibit the blastogenic response to phytohemagglutinin and E-rosette function of normal lymphocytes in patients affected with dilated cardiomyopathy. We found them to be present in significantly higher leve...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Franceschini R,Petillo A,Corazza M,Azzolini A,Nizzo MC,Gianrossi R

    更新日期:1984-10-01 00:00:00

  • Influence of atenolol on coronary artery spasm after acute myocardial infarction in a Japanese population.

    abstract:BACKGROUND:Japanese patients with acute myocardial infarction (MI) have a greater incidence of coronary artery spasm than Caucasians. Some beta-blockers have been reported to aggravate coronary spasm. This study sought to assess the effects of beta-adrenoceptor blockade on coronary vasospasm in Japanese patients with a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Shirotani M,Yokota R,Kouchi I,Hirai T,Uemori N,Haba K,Hattori R

    更新日期:2010-03-04 00:00:00

  • Glycative and oxidative stress are associated with altered thrombus composition in diabetic patients with ST-elevation myocardial infarction.

    abstract:BACKGROUND:The role of type 2 diabetes (T2DM) on composition of thrombus has not been fully characterized in patients with ST-elevation myocardial infarction (STEMI). AIMS:To elucidate the differences between diabetic and non-diabetic patients with STEMI in relation to the composition of coronary thrombus, and the pot...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Sambola A,Ruiz-Meana M,Barba I,Del Blanco BG,Barrabés JA,Lip GY,Vilardosa Ú,Sansaloni S,Rello P,García-Dorado D

    更新日期:2017-09-15 00:00:00

  • The effects of exercise modality on maximal and submaximal exercise parameters obtained by graded maximal exercise testing.

    abstract:BACKGROUND:Cardiopulmonary exercise testing (CPET) has become part of screening and evaluation in cardiology. The exercise modalities most often used in CPET are the treadmill (TM) and upright bicycle (UB). Nowadays, also the supine bicycle (SB) is becoming more often used, especially when combined with cardiac imaging...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Cornelis N,Buys R

    更新日期:2016-11-01 00:00:00