Abstract:
AIM:To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS:We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death. RESULTS:During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events. CONCLUSION:Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Coppola G,Corrado E,Muratori I,Tantillo R,Vitale G,Lo Coco L,Novo Sdoi
10.1016/j.ijcard.2004.12.051subject
Has Abstractpub_date
2006-01-04 00:00:00pages
16-20issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(05)00302-5journal_volume
106pub_type
杂志文章abstract:INTRODUCTION:A number of challenges can affect long-term performance of endocardial implanted systems in pediatric patients. Select Secure™ lead offers potential advantages for this population. This analysis aims to evaluate long-term performance of this lead in children, with and without congenital heart disease. MET...
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更新日期:2016-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 信件
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更新日期:2008-07-21 00:00:00
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更新日期:1988-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-11-15 00:00:00
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更新日期:2020-12-06 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-06-25 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-03-03 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2010-10-29 00:00:00
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