Cycle-ergometry stress testing and use of chronotropic reserve adjustment of ST depression for identification of significant coronary artery disease in clinical practice.


:Diagnostic reliability of indexations of peak exercise ST segment depression (DeltaST) for heart rate reserve (HRi) or chronotropic reserve (CR) to identify significant coronary artery disease (CAD) by cycle-ergometer exercise testing has not been evaluated previously. Exercise testing by upright cycle-ergometer (25 W/3 min) were performed in consecutive patients in primary prevention with history of exercise-related chest discomfort and cardiovascular risk factors, or with overt peripheral artery disease, with or type-2 diabetes associated with two or more additional cardiovascular risk factors. Coronary angiography was performed after the test to assess significant CAD. Three different criteria for definition of inducible myocardial ischemia were tested versus significant CAD: peak DeltaST>or=100 microV, ST/HRi>1.69 microV/bpm or ST/CR>1.76 microV/%. Diagnostic accuracy vs. CAD of DeltaST>or=100 microV, of ST/HRi>1.69 microV/bpm, and of ST/CR>1.76 microV/% were 78%, 72%, and 89% respectively; sensitivity and specificity of the three criteria were 91% and 50%, 84% and 43%, 88% and 93%, respectively. Abnormal ST/CR predicted CAD independent of risk factors, pre-test probability, and more strongly than DeltaST. Combination of ST/HRi and ST/CR criteria did not improve CAD prediction. In conclusions, in clinical setting in patients in primary prevention but with moderate-to-high pre-test probability of CAD, exercise testing by cycle-ergometry and use of ST/CR>1.76 microV/% showed elevated sensitivity and specificity, and the best accuracy for diagnosis of significant CAD.


Int J Cardiol


Palmieri V,Pezzullo S,Arezzi E,D'Andrea C,Cassese S,Martino S,Celentano A




Has Abstract


2008-07-21 00:00:00














  • Exercise oscillatory ventilation in heart failure.

    abstract::Ventilation inefficiency has become a matter of interest for heart failure (HF) specialists, the most remarkable being exertional oscillatory ventilation (EOV). EOV is an abnormal ventilatory phenomenon, originally described as anecdotal, but now considered a marker of disease severity and worst prognosis in HF. EOV i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Corrà U

    更新日期:2016-03-01 00:00:00

  • Prolonged beneficial effect of bosentan treatment and 4-year survival rates in adult patients with pulmonary arterial hypertension associated with congenital heart disease.

    abstract::Pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) due to systemic to pulmonary shunting is associated with a high risk of morbidity and mortality. In this study we evaluated 4 years treatment effect of bosentan on exercise capacity and quality of life and survival rates in 64 adult p...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Vis JC,Duffels MG,Mulder P,de Bruin-Bon RH,Bouma BJ,Berger RM,Hoendermis ES,van Dijk AP,Mulder BJ

    更新日期:2013-03-20 00:00:00

  • The combined effect of physical activity and sedentary behaviors on a clustered cardio-metabolic risk score: The Helena study.

    abstract:BACKGROUND/OBJECTIVE:Increased physical activity (PA) and decreased sedentary behaviors (SBs) may have beneficial effects on cardio-metabolic risk in adolescents. The aim of this study was to examine the associations between independent/combined effects of PA and SB with individual/clustered cardio-metabolic risk facto...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Rendo-Urteaga T,de Moraes AC,Collese TS,Manios Y,Hagströmer M,Sjöström M,Kafatos A,Widhalm K,Vanhelst J,Marcos A,González-Gross M,De Henauw S,Ciarapica D,Ruiz JR,España-Romero V,Molnár D,Carvalho HB,Moreno LA,HELENA S

    更新日期:2015-01-01 00:00:00

  • Clinical use of transoesophageal atrial stimulation in terminating ventricular tachycardia.

    abstract::This study was performed to evaluate whether transoesophageal atrial pacing could also stop ventricular tachycardias with low rates and no haemodynamic impairment. Prior to resorting to ventricular endocardial pacing, seven male patients, aged between 15 and 73 years, were treated by transoesophageal atrial pacing for...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Favale S,Minafra F,Amodio G,Tritto M,Massari V,Rizzon P

    更新日期:1990-09-01 00:00:00

  • Is 3D echocardiography superior to 2D echocardiography in general practice? A systematic review of studies published between 2007 and 2012.

    abstract:BACKGROUND:Recent developments in 3-dimensional echocardiography (3DE) have resulted in smaller probes, faster data acquisition and wider applicability. In spite of this, there is still an ongoing debate as to its ability to provide additional information to 2DE in general hospital clinical practice. METHODS:A systema...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Ruddox V,Mathisen M,Bækkevar M,Aune E,Edvardsen T,Otterstad JE

    更新日期:2013-09-30 00:00:00

  • Effects of synthetic progestagens on autonomic tone, neurohormones and C-reactive protein levels in young healthy females in reproductive age.

    abstract:BACKGROUND:Heart rate variability and baroreceptor sensitivity are measures of autonomic control. While progestagen-containing replacement therapy in postmenopausal women adversely affects autonomic balance, the impact of hormonal contraceptives with synthetic progestagens on autonomic activity, neurohormones and C-rea...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Schueller PO,Feuring M,Sharkova Y,Grimm W,Christ M

    更新日期:2006-07-28 00:00:00

  • Inflammation versus mechanical stretch biomarkers over time in acutely decompensated heart failure with reduced ejection fraction.

    abstract::Heart failure can be associated with inflammation but it is unclear if inflammation is directly related to hemodynamic worsening or is an independent pathway. Our aim was to investigate inflammation and mechanical stress using serial measurements of biomarkers in acute and chronic heart failure with reduced ejection f...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章


    authors: Boulogne M,Sadoune M,Launay JM,Baudet M,Cohen-Solal A,Logeart D

    更新日期:2017-01-01 00:00:00

  • Electrocardiographic identification of prior myocardial infarction during right ventricular pacing--effect of septal versus apical pacing.

    abstract:BACKGROUND:Electrocardiographic (ECG) identification of prior myocardial infarction (MI) during right ventricular (RV) pacing is of clinical importance. Proposed ECG criteria have been evaluated only during apical pacing. We evaluated the effect of pacing site on the predictive performance of ECG signs of prior MI. ME...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tzeis S,Andrikopoulos G,Asbach S,Semmler V,Lennerz C,Solzbach U,Vrazic H,Kloppe A,Klein N,Pastromas S,Biermann J,Kolb C,SPICE study investigators.

    更新日期:2014-12-20 00:00:00

  • Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling.

    abstract:BACKGROUND:Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to investigate the potential ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Fuentes F,Alarcón M,Badimon L,Fuentes M,Klotz KN,Vilahur G,Kachler S,Padró T,Palomo I,Fuentes E

    更新日期:2017-12-01 00:00:00

  • Cardiac effects of acute exhaustive exercise in a rat model.

    abstract:BACKGROUND:The role of physical exercise in the prevention and treatment of cardiovascular diseases has been well described, however, elevations in cardionecrotic biomarkers after prolonged exercise (i.e. ultramarathon running) were observed. We aimed at understanding the biochemical, molecular biological, structural a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Oláh A,Németh BT,Mátyás C,Horváth EM,Hidi L,Birtalan E,Kellermayer D,Ruppert M,Merkely G,Szabó G,Merkely B,Radovits T

    更新日期:2015-03-01 00:00:00

  • Transient postoperative pericardial constriction in a child.

    abstract::Constrictive pericarditis has been defined classically as a progressive condition, characterized by pericardial fibrosis, with or without calcification, which results in chronic refractory congestive heart failure and for witch pericardiectomy is often required. In the last decades there have been reports describing a...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Betrián Blasco P,Comas JG,Ferrer JC,Menduña QF,García BM,Ipiña FG

    更新日期:2009-01-09 00:00:00

  • A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales.

    abstract:BACKGROUND:The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary cohort of PCI treated patients, which would: predict 30 day mortality; provid...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: McAllister KS,Ludman PF,Hulme W,de Belder MA,Stables R,Chowdhary S,Mamas MA,Sperrin M,Buchan IE,British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.

    更新日期:2016-05-01 00:00:00

  • Prevalence of, associations with, and prognostic role of anemia in heart failure across the ejection fraction spectrum.

    abstract:BACKGROUND:The role of anemia in heart failure with mid-range and preserved ejection fraction (HFmrEF, EF 40-49% and HFpEF, EF ≥50%) is unknown. We aimed to compare prevalence of, associations with, and prognostic role of anemia in HF across the EF spectrum. METHODS:In patients from the Swedish HF Registry, we assesse...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Savarese G,Jonsson Å,Hallberg AC,Dahlström U,Edner M,Lund LH

    更新日期:2020-01-01 00:00:00

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    abstract:BACKGROUND AND AIMS:Plasma aldosterone has been associated with all-cause and cardiovascular mortality in high-risk cardiovascular populations, including patients with heart failure, myocardial infarction and high-risk coronary artery disease (CAD) patients. In the present study, we evaluated the association of plasma ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Hillaert MA,Lentjes EG,Kemperman H,van der Graaf Y,Nathoe HM,Beygui F,Montalescot G,Doevendans PA,Wassink AM,van Belle E,SMART Study Group.

    更新日期:2013-09-01 00:00:00

  • Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis.

    abstract:BACKGROUND:Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ven...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Vives-Gilabert Y,Sanz-Sánchez J,Molina P,Cebrián A,Igual B,Calvillo-Batllés P,Domingo D,Millet J,Martínez-Dolz L,Castells F,Zorio E

    更新日期:2019-01-01 00:00:00

  • Use of aspirin in conjunction with angiotensin-converting enzyme inhibitors does not worsen long-term survival in heart failure.

    abstract:BACKGROUND:A negative interaction has been shown to exist between aspirin and angiotensin-converting enzyme inhibitors (ACE-I) in subjects with heart failure. We explored the effect of combined ACE-I and aspirin therapy compared to ACE-I without aspirin on clinical outcomes in patients with heart failure. METHODS:430 ...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章


    authors: Harjai KJ,Solis S,Prasad A,Loupe J

    更新日期:2003-04-01 00:00:00

  • Pacing in congenital heart disease - A four-decade experience in a single tertiary centre.

    abstract:BACKGROUND:The increased risk of brady- and tachy-arrhythmias in the congenital heart disease (CHD) population means that cardiac rhythm management devices are often required at an early age and expose patients to device-related complications. The present study drew upon four decades of experience at a tertiary adult c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Midha D,Chen Z,Jones DG,Williams HJ,Lascelles K,Jarman J,Clague J,Till J,Dimopoulos K,Babu-Narayan SV,Markides V,Gatzoulis MA,Wong T

    更新日期:2017-08-15 00:00:00

  • Release of cardiac troponin I after temporally graded acute coronary ischaemia with electrocardiographic ST depression.

    abstract:BACKGROUND:Elevation of cardiac biochemical markers and ST segment depression in the electrocardiogram have important roles in the risk stratification of unstable coronary syndromes. We assessed graded duration of acute coronary ischaemia with ST depression versus release of cardiac troponin I (cTnI) and conventional c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Vikenes K,Westby J,Matre K,Kuiper KK,Farstad M,Nordrehaug JE

    更新日期:2002-10-01 00:00:00

  • Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial.

    abstract:BACKGROUND:Platelet inhibition has been linked to improved endothelial function, a prognostic factor in coronary artery disease. Whether prasugrel, a potent platelet inhibitor, affects endothelial function remains unknown. METHODS:This was a double-blind, randomized, active-controlled, parallel trial. Patients with un...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Rudolph TK,Fuchs A,Klinke A,Schlichting A,Friedrichs K,Hellmich M,Mollenhauer M,Schwedhelm E,Baldus S,Rudolph V

    更新日期:2017-12-01 00:00:00

  • Atrial septal defect in adults > or =40 years old: negative impact of low arterial oxygen saturation.

    abstract:BACKGROUND:Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients. We studied unoperated patients aged over 40 years to define the patterns of present...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Rosas M,Attie F,Sandoval J,Castellano C,Buendía A,Zabal C,Granados N

    更新日期:2004-02-01 00:00:00

  • Long-term outcome of prosthesis-patient mismatch after transcatheter aortic valve replacement.

    abstract:BACKGROUND:Incidence and long-term clinical consequences of prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) are still unclear. METHODS:We enrolled 710 consecutive patients who underwent TAVR. PPM was defined as absent if the index orifice area (iEOA) was >0.85 cm2/m2, moderate if ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Compagnone M,Marchetti G,Taglieri N,Ghetti G,Bruno AG,Orzalkiewicz M,Marrozzini C,Bacchi Reggiani ML,Palmerini T,Galiè N,Saia F

    更新日期:2020-11-01 00:00:00

  • Malignant pheochromocytoma.

    abstract::We present an interesting case of paroxysmal hypertension in a young male caused by malignant pheochromocytoma. This patient, who had history of paroxysms of abdominal pain with severe hypertension, developed osseous metastasis in the first lumbar vertebra resulting in collapse of the vertebra and it caused paraplegia...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Pande AK

    更新日期:1992-03-01 00:00:00

  • Impact and influence of "omics" technology on hyper tension studies.

    abstract:BACKGROUND:Hypertension is an important risk factor for cardiovascular diseases. Pathophysiology and molecular mechanisms involved in hypertension regulation are not very well known. Recently, high-throughput Next-Generation Sequencing (NGS) technology has identified hundreds of gene loci associated with multiple cardi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Costa A,Franco OL

    更新日期:2017-02-01 00:00:00

  • Effect of part-time cardiac catheterization facilities in patients with acute myocardial infarction.

    abstract:BACKGROUND:Although the easy availability of invasive cardiac care facilities is associated with an increase in their use, their influence on outcomes is not clear. We sought to investigate whether a newly available cardiac catheterization laboratory (CCL) performing percutaneous coronary intervention (PCI) on a part-t...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Consuegra-Sánchez L,Jaulent-Huertas L,Vicente-Gilabert M,Díaz-Pastor Á,Escudero-García G,Alonso-Fernández N,Gil-Sánchez FJ,Martínez-Hernández J,Sanchis-Forés J,Galcerá-Tomás J,Melgarejo-Moreno A

    更新日期:2017-06-01 00:00:00

  • Results of the Women's Health Study of Accra: assessment of blood pressure in urban women.

    abstract:BACKGROUND:The Women's Health Study of Accra was conducted to determine the burden of illness in a representative sampling of adult urban women. METHODS:This community-based survey selected study participants by a 2-stage cluster probability sample stratified by socioeconomic status based on the 2000 Ghanaian census d...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Duda RB,Kim MP,Darko R,Adanu RM,Seffah J,Anarfi JK,Hill AG

    更新日期:2007-04-12 00:00:00

  • Aortic stenosis and non-cardiac surgery: A systematic review and meta-analysis.

    abstract:BACKGROUND:Aortic stenosis (AS) poses a perioperative management dilemma to physicians looking after patients who require non-cardiac surgery. The objective of this review is to investigate mortality and adverse cardiovascular events in patients with and without AS who underwent non-cardiac surgery. METHODS:We searche...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Kwok CS,Bagur R,Rashid M,Lavi R,Cibelli M,de Belder MA,Moat N,Hildick-Smith D,Ludman P,Mamas MA

    更新日期:2017-08-01 00:00:00

  • Chronic medication intake in patients with stable coronary heart disease across Europe: Evidence from the daily clinical practice. Results from the ESC EORP European Survey of Cardiovascular Disease Prevention and Diabetes (EUROASPIRE IV) Registry.

    abstract:BACKGROUND:As advised by the European guidelines on cardiovascular prevention, medication intake is a major component of secondary prevention. The aim of this study is to provide an in-depth overview of the medication intake in stable European coronary heart disease (CHD) patients. METHODS:Analyses are based on the EU...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: De Smedt D,De Backer T,Petrovic M,De Backer G,Wood D,Kotseva K,De Bacquer D

    更新日期:2020-02-01 00:00:00

  • Doxazosin GITS versus standard doxazosin in mild to moderate hypertension.

    abstract:BACKGROUND:The selective alpha 1-adrenoceptor antagonist doxazosin in both standard formulation and gastrointestinal therapeutic system (GITS) controlled-release formulation is effective for hypertension without having a negative impact on serum lipids. This study was designed to compare the relative efficacy of these ...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Calvo C,Gil-Extremera B,Gomez-Fernández P,Masramon X,Pueyo C,Armada B

    更新日期:2005-05-11 00:00:00

  • Novel techniques of mechanical circulatory support for the right heart and Fontan circulation.

    abstract:BACKGROUND:Currently available ventricular assist devices are designed primarily for use in patients with left sided heart failure. This study evaluated the efficacy of the Jarvik 2000 ventricular assist device (VAD) as a pulmonary pump to power a Fontan circuit in a large animal model. METHODS:Without the use of card...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Derk G,Laks H,Biniwale R,Patel S,De LaCruz K,Mazor E,Williams R,Valdovinos J,Levi DS,Reardon L,Aboulhosn J

    更新日期:2014-10-20 00:00:00

  • Anti-ischemic effects of celiprolol in patients with exercise-induced angina pectoris.

    abstract::The anti-ischemic properties of the new cardioselective beta-adrenoreceptor antagonist celiprolol were investigated in an open study of 12 men (mean age: 58 +/- 6.6 years) with exercise-induced angina pectoris. After all previous anti-anginal medication had been withdrawn for at least 5 half-lives, the patients receiv...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章


    authors: Douard H,Koch M,Laporte T,Abella ML,Provendier O,Broustet JP

    更新日期:1989-10-01 00:00:00