Abstract:
BACKGROUND:Current clinical guidelines recommend that risk stratification for ischaemic stroke in patients with nonvalvular AF (NVAF) should be performed using the CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age≥ 75years [double], Diabetes mellitus, previous thromboembolism [double], Vascular disease, Age 65-74years, and female gender) to aid decision making for antithrombotic treatment, with a preference for Non-Vitamin K Oral Anticoagulants (NOACs) in those with CHA2DS2-VASc score ≥1. However, CHA2DS2-VASc score is not recommended in the 2014 Japanese Circulation Society (JCS) guidelines for patients with NVAF. METHODS:To assess the impact of the JCS approach to stroke prevention in AF, and model the impact of using a CHA2DS2-VASc based 2-step decision making strategy, we calculated the incidence of ischaemic stroke in NVAF patients without OAC on basis of the CHADS2 and CHA2DS2-VASc scores using published Japanese data, and estimated the preventable number of stroke events. RESULTS:Using a CHA2DS2-VASc-based approach, the potential annual stroke events based on the estimated total number of NVAF patients in Japan was 889,000, as follows: 4369 for dabigatran 150 mg, 6049 for dabigatran 110mg, 5918 for rivaroxaban (intention-to-treat; ITT), 5302 for apixaban, 5843 for edoxaban 60mg (ITT), and 7598 for edoxaban 30 mg (ITT), respectively. Using a CHADS2 score-based approach, the number of potential stroke events was much greater for each agent. CONCLUSION:Our modelling analysis has shown that when considering antithrombotic treatment for Japanese NVAF patients, using a CHA2DS2-VASc-based approach would allow greater opportunities for stroke prevention.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Senoo K,Lane DA,Lip GYdoi
10.1016/j.ijcard.2014.11.196subject
Has Abstractpub_date
2015-02-15 00:00:00pages
247-54eissn
0167-5273issn
1874-1754pii
S0167-5273(14)02377-8journal_volume
181pub_type
杂志文章abstract:AIMS:The association between aortic valve sclerosis (AVSc) and cardiovascular (CV) events is not consistent among different studies. We have performed a meta-analysis evaluating the association between AVSc and fatal and/or non-fatal CV and cerebrovascular events. METHODS AND RESULTS:A systematic search was performed ...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2018.01.054
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:In the magnetic resonance T1-weighted imaging, some investigators have shown that coronary artery high-intensity signals (HISs) are associated with vulnerable plaque morphology and an increased risk of future cardiac events. Although previous studies used different PMR (the ratio between the signal intensiti...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.12.028
更新日期:2017-03-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2017-12-01 00:00:00
abstract::Myocardial infarct size is one of the most important predictors of prognosis in patients suffering an acute myocardial infarction. It can be assessed by enzymatic and electrocardiographic methods. The present report compares dynamic vectorcardiographic monitoring, serial plasma enzyme activity measurements and QRS sco...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:Hypertension induces cardiac dysfunction, calcium (Ca(2+)) dysregulation, and arrhythmogenesis. Dipeptidyl peptidase (DPP)-4 inhibitors, an antidiabetic agent with anti-inflammation and anti-hypertension potential, may regulate peroxisome proliferator-activated receptors (PPARs)-α, -γ, and -δ and Ca(2+) home...
journal_title:International journal of cardiology
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abstract:BACKGROUND:The rapid adoption of percutaneous transluminal coronary angioplasty (PTCA) in Korea is provoking a widespread concern about possible overuse of this procedure with inappropriate indications. This study aimed to assess the rate of appropriate application of PTCA in Korea and investigate factors affecting thi...
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pub_type: 杂志文章
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abstract:BACKGROUND:Human obesity has been associated with alterations of vascular structure, especially in large and medium arteries, but the effects of insulin-sensitizers are not well known. METHODS:Twenty-five male Wistar rats received subcutaneous injections of monosodium glutamate (MSG) or an equivalent volume of vehicle...
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pub_type: 杂志文章
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更新日期:2013-05-25 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00002-9
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journal_title:International journal of cardiology
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abstract:BACKGROUND:In addition to standard therapy with ACE-inhibitors, digitalis and diuretics, beta-adrenergic receptor blockers have become a widely accepted strategy in the treatment of chronic heart failure. The role of calcium antagonists in CHF however remains controversial. To evaluate if a combination therapy of metop...
journal_title:International journal of cardiology
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doi:10.1016/j.ijcard.2008.02.022
更新日期:2009-02-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2009-02-06 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0167-5273(95)02441-x
更新日期:1995-11-10 00:00:00
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pub_type: 杂志文章
doi:10.1016/0167-5273(84)90091-3
更新日期:1984-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.11.184
更新日期:2008-02-29 00:00:00
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journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2008.04.005
更新日期:2009-05-29 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.08.011
更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0167-5273(89)90252-0
更新日期:1989-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2014.06.051
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-15 00:00:00
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pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 历史文章,杂志文章
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2009-11-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-01-15 00:00:00
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pub_type: 信件
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更新日期:2010-12-03 00:00:00