Abstract:
:Cardiovascular morbidity and mortality in patients with type 2 diabetes are a major problem in clinical practice. Thiazolidinediones (TZDs) are agonists of the peroxisome proliferator-activated receptor gamma which improve glycaemic control by reducing insulin resistance. TZDs also seem to have beneficial effects on various cardiovascular risk factors and consequently may have the potential to reduce the risk of cardiovascular disease (CVD). Although the first large-scale clinical trial evaluating the effect of a TZD on secondary prevention of major adverse cardiovascular outcomes supported this hypothesis, a recently published meta-analysis raised substantial uncertainty about the cardiovascular safety of rosiglitazone. This article summarises the evidence from completed and ongoing outcome trials with TZDs, as well as the recent meta-analytic data on their cardiovascular safety, aiming to provide an up-to-date and balanced view of a very important field. Data from clinical trials consistently indicate that treatment with glitazones significantly increase the risk of heart failure. Despite the fact that rosiglitazone and pioglitazone have much more similarities than differences with regards to their effects on cardiovascular risk factors, pioglitazone seems to have more favourable effects on major cardiovascular outcomes. This issue also highlights the potential hazards involved in using surrogate end-points for drug approval.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Stafylas PC,Sarafidis PA,Lasaridis ANdoi
10.1016/j.ijcard.2008.06.005subject
Has Abstractpub_date
2009-01-24 00:00:00pages
298-304issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(08)00799-7journal_volume
131pub_type
杂志文章,评审abstract::A 42-year-old man was hospitalized for investigation of repeated episodes of ventricular fibrillation (Vf). Electrocardiogram (ECG) showed typical features of Brugada syndrome. Echocardiography, coronary angiography and endomyocardial biopsy specimen were normal. 123I-MIBG scintigraphy showed homogeneous reduction of ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00014-x
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:The interaction of left ventricular outflow tract (LVOT) and transcatheter heart valve (THV) is complex and may be device design specific. We sought to study LVOT characteristics and its relation with permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR). METHODS:We stud...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.04.023
更新日期:2016-08-01 00:00:00
abstract::Despite the advances in imaging modalities and surgical techniques, the management of adults with congenital heart disease (ACHD) over the years has remained largely empirical rather than evidence-based. Animal models have been difficult to develop and very costly, while clinical trials are difficult to design and per...
journal_title:International journal of cardiology
pub_type: 社论
doi:10.1016/j.ijcard.2008.10.039
更新日期:2009-04-03 00:00:00
abstract:PURPOSE:To determine the long-term mortality of patients with non-ST-segment elevation acute coronary syndromes (NSTEACS) that are eligible versus those not eligible in randomized controlled trials (RCT), and how each exclusion criteria is associated with outcome. METHODS:Common causes of exclusion in six published RC...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.12.027
更新日期:2008-02-20 00:00:00
abstract:BACKGROUND:The R820W mutation in the MYBPC3 gene has been associated with the development of hypertrophic cardiomyopathy (HCM) in rag-doll cats, but had not been described in humans. AIMS:To describe the phenotype associated with the R820W mutation identified in a human family. METHODS:The R820W was identified by dir...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2010.04.032
更新日期:2010-11-19 00:00:00
abstract:BACKGROUND:The association of soluble interleukin-1 receptor-like 1 (ST2) with left ventricular (LV) remodeling is unclear in patients with a first ST-segment elevation myocardial infarction (STEMI). The objective of this work was to assess the relationship between ST2, a marker of inflammation, and cardiac magnetic re...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.06.073
更新日期:2018-11-01 00:00:00
abstract::Annuloaortic ectasia (AAE) associated with aortic regurgitation (AR) is a rare involvement in Takayasu arteritis. There are many difficult problems in surgical treatment of this lesion because of its inflammatory nature. We developed a composite graft repair technique to avoid complications associated with Bentall typ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00169-7
更新日期:1998-10-01 00:00:00
abstract:UNLABELLED:Plasma levels of PIIINP a marker of extracellular matrix metabolism activity have been linked to abdominal aortic aneurysm growth rate, but its relationship with thoracic aortic aneurysm (TAA) growth has never previously been studied. OBJECTIVE:To demonstrate the value of assay of "aminoterminal propeptide ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2010.02.051
更新日期:2010-11-19 00:00:00
abstract::We sought to investigate the relative clinical significance of target and nontarget lesions repeated percutaneous coronary intervention (re-PCI) in patients implanted with drug-eluting stents (DES). Out of 2626 consecutive DES patients, we retrospectively selected 166 (6.3%; 123 males, aged 65±10 years) who had a clin...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.11.049
更新日期:2010-11-19 00:00:00
abstract::The human serum HDL-linked paraoxonase enzyme limits the LDL peroxidation by preventing transformation of LDL into biologically active atherogenic particles. Paraoxonase serum activity varies among individuals due to an Gln/Arg polymorphism with low (A phenotype) and high activity (B phenotype). The present study corr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00209-5
更新日期:1998-09-30 00:00:00
abstract:INTRODUCTION:Whether in patients with acute central sub-massive or non-massive pulmonary embolism, mild troponin I increase (>0.03 mug/L) predicts in-hospital occurrence of hemodynamic instability and death independent to prognostically relevant clinical, laboratory and echocardiographic information is not fully establ...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2006.03.096
更新日期:2008-03-14 00:00:00
abstract::The present study investigated the genetic variation of 3' flanking region of ApoA-I (PstI), 3' untranslated region of ApoC-III (SstI) and intron 2 of ApoA-IV (XbaI) in 193 angiographically diagnosed CHD patients and 150 CHD negative controls of Punjab, Northwest India. Haplotype analysis reveals that P2-S2-X1 is a su...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.07.029
更新日期:2008-11-28 00:00:00
abstract:BACKGROUND:Oestrogen alters megakaryocyte number in humans and mice. In mice, high-dose oestrogen stimulates an initial increase in megakaryocyte number followed by a decrease. However, the cellular action, effect of physiologically circulating and smaller supra-physiological oestrogen doses and whether changes in mega...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.06.037
更新日期:2006-05-24 00:00:00
abstract:BACKGROUND:Dendritic cells (DCs) are the most potent antigen-presenting cells and play a central role in initiating the primary immune response. Although increasing evidence supports immune-mediated inflammation plays an important role in the pathophysiology of heart failure, little is known regarding the source and me...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.09.524
更新日期:2011-03-03 00:00:00
abstract::This report describes the usefulness of transesophageal atrial pacing in the treatment of five patients with hyperkalemia-induced bradycardias. Three patients had marked sinus bradycardia while the other two had a regular rhythm with QRS of left bundle branch block morphology, with no P waves visible on the surface el...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90110-1
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:The role of type 2 diabetes (T2DM) on composition of thrombus has not been fully characterized in patients with ST-elevation myocardial infarction (STEMI). AIMS:To elucidate the differences between diabetic and non-diabetic patients with STEMI in relation to the composition of coronary thrombus, and the pot...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.04.089
更新日期:2017-09-15 00:00:00
abstract::A 13-year-old black male who died suddenly as a result of atresia of the left coronary ostium and left main coronary artery is presented. An association between this anomaly and supravalvar aortic stenosis is observed. The literature is reviewed and 14 similar cases are compared. Presentation of this anomaly is variab...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/0167-5273(89)90284-2
更新日期:1989-03-01 00:00:00
abstract::Cross-sectional and Doppler echocardiographic characteristics of infective endocarditis are described in six cases following patch closure of a ventricular septal defect. The patients presented to us with fever one to five months after surgery. Five of them also had congestive cardiac failure. Cross-sectional echocard...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90158-7
更新日期:1989-10-01 00:00:00
abstract::Isolated noncompaction of the ventricular myocardium is an unclassified cardiomyopathy and is thought to be due to arrest of myocardial morphogenesis. Fetal arrhythmias may occur in approximately half of the patients and account for the death in this disorder. We describe a patient with isolated noncompaction of the r...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.07.037
更新日期:2008-12-17 00:00:00
abstract:BACKGROUND:18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a feasible method to investigate the inflammatory activity of the myocardium in cardiac sarcoidosis. However, PET is costly and not as widely available as standard electrocardiogram (ECG). Current ECG findings related to cardiac sarcoidosis a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.07.027
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to investigate the potential ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.08.006
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Coronary artery spasm (CAS) is known to be a risk factor of acute coronary syndrome and angina pectoris. However, there is no currently available data with larger study population regarding long-term clinical outcomes of CAS in real world clinical practice. OBJECTIVES:We evaluated the prevalence of CAS and ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.02.021
更新日期:2015-04-01 00:00:00
abstract::A 61-year-old man was referred at our hospital for a cardiac evaluation after an episode of oppressive chest pain at rest. He was discharged with a MRI diagnosis of non-compaction cardiomyopathy presented with typical angina, left ventricle dysfunction and ischemic EKG findings without atherosclerotic narrowing and al...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.097
更新日期:2010-04-30 00:00:00
abstract:BACKGROUND:Acute heart failure (HF) is a frequently encountered cardiac condition. Its prevalence increases exponentially with age. In spite of this, elderly patients are underrepresented in clinical trials and the implementation of guideline-based medical therapy (GBMT) in them is not well established. We investigated...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.070
更新日期:2017-05-15 00:00:00
abstract::We report a rare case of torsade de pointes, a polymorphic ventricular tachycardia associated with QT interval prolongation, caused by intravenous ciprofloxacin given for pneumonia in a 22-year-old healthy Marine. Although the risk for quinolone-associated torsade de pointes appears to be low, caution is still warrant...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.08.048
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND:Cardiac magnetic resonance (CMR) imaging with velocity encoding along all three directions of flow, known as 4DFlow CMR, provides both anatomical and functional information. Few data are available on the usefulness of 4DFlow CMR in everyday practice. Here, our objective was to investigate the usefulness of 4...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.07.021
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Cachexia is a common complication of cancer and may be responsible for 22% of all cancer-related deaths. The exact cause of death in cancer cachexia patients is unknown. Recently, atrophy of the heart has been described in cancer cachexia animal models, which resulted in impaired cardiac function and is like...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.05.063
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:Patient outcomes after acute myocardial infarction (AMI) are influenced by the combined activation of several distinct interrelated signaling pathways. Specifically acute-phase response proteins can neutralize inflammatory agents, minimize the extent of tissue damage, and participate in tissue repair and reg...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.07.181
更新日期:2013-10-15 00:00:00
abstract::With the advent of transesophageal echocardiography (TEE), thrombi of the aorta are becoming increasingly recognized as possible sources of systemic emboli. This report describes a 58-year-old woman with multiple unexplained peripheral emboli. A giant thrombus of the descending aorta has been identified as the source ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/s0167-5273(02)00509-0
更新日期:2003-06-01 00:00:00
abstract::The optimal degree of revascularization for patients with chronic multivessel coronary artery disease remains an unsolved issue. Intuitively, complete revascularization decreases cardiovascular events and improves outcomes compared to incomplete procedures, but in recent years the concept of incomplete revascularizati...
journal_title:International journal of cardiology
pub_type: 社论
doi:10.1016/j.ijcard.2016.09.055
更新日期:2016-12-01 00:00:00