当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.

The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.

Abstract：

BACKGROUND:Cachexia is a common complication of cancer and may be responsible for 22% of all cancer-related deaths. The exact cause of death in cancer cachexia patients is unknown. Recently, atrophy of the heart has been described in cancer cachexia animal models, which resulted in impaired cardiac function and is likely to contribute to mortality. In cancer patients hyperuricaemia independent of tumour lysis syndrome is often associated with a worse prognosis. Xanthine oxidase (XO) metabolizes purines to uric acid and its inhibition has been shown to improve clinical outcome in patients with chronic heart failure. METHODS:The rat Yoshida AH-130 hepatoma cancer cachexia model was used in this study. Rats were treated with 4 or 40 mg/kg/d oxypurinol or placebo starting one day after tumour-inoculation for maximal 15 days. Cardiac function was analyzed by echocardiography on day 11. RESULTS:Here we show that inhibition of XO by oxypurinol significantly reduces wasting of the heart and preserves cardiac function. LVEF was higher in tumour-bearing rats treated with 4 mg/kg/d (61±4%) or 40 mg/kg/d (64±5%) oxypurinol vs placebo (51±3%, both p<0.05). Fractional shortening was improved by 4 mg/kg/d (43±3%) oxypurinol vs placebo (30±2, p<0.05), while 40 mg/kg/d oxypurinol (41±5%) did not reach statistical significance. Cardiac output was increased in the 4 mg/kg/d dose only (71±11 mL/min vs placebo 38±4 mL/min, p<0.01). CONCLUSION:Inhibition of XO with oxypurinol has beneficial effects on cardiac mass and function in a rat model of severe cancer cachexia, suggesting that XO might be a viable drug target in cancer cachexia.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Springer J,Tschirner A,Hartman K,von Haehling S,Anker SD,Doehner W

doi

10.1016/j.ijcard.2013.05.063

subject

Has Abstract

pub_date

2013-10-09 00:00:00

pages

3527-31

issue

4

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(13)00991-1

journal_volume

168

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • External pacing for the termination of sustained supraventricular tachycardia in children.

    abstract：:Cardiac pacing from either endocardial or transesophageal sites has proven useful in termination of sustained supraventricular tachycardia in children. In two patients we demonstrated the efficacy of external pacing in the termination of sustained supraventricular tachycardia. The ease and apparent safety of the techn...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(90)90056-b

    authors： Grubb BP,Temesy-Armos P,Hahn H,Elliott L

    更新日期：1990-08-01 00:00:00

  • Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension.

    abstract：BACKGROUND/OBJECTIVES:Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.010

    authors： Sakao S,Daimon M,Voelkel NF,Miyauchi H,Jujo T,Sugiura T,Ishida K,Tanabe N,Kobayashi Y,Tatsumi K

    更新日期：2016-09-15 00:00:00

  • Gastrointestinal complications associated with catheter ablation for atrial fibrillation.

    abstract：:Atrial fibrillation is the most common arrhythmia in the United States. With the ageing population, the incidence and prevalence of atrial fibrillation are on the rise. Catheter ablation of atrial fibrillation is a widely accepted treatment modality in patients with drug refractory symptomatic paroxysmal or persistent...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.09.069

    authors： Garg L,Garg J,Gupta N,Shah N,Krishnamoorthy P,Palaniswamy C,Bozorgnia B,Natale A

    更新日期：2016-12-01 00:00:00

  • Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia.

    abstract：BACKGROUND:Experimental studies demonstrate that higher intake of omega-3 fatty acids (n-3 FA) improves insulin sensitivity, however, we reported that n-3 FA 2g therapy, most commonly used dosage did not significantly improve insulin sensitivity despite reducing triglycerides by 21% in patients. Therefore, we investiga...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2014.07.075

    authors： Oh PC,Koh KK,Sakuma I,Lim S,Lee Y,Lee S,Lee K,Han SH,Shin EK

    更新日期：2014-10-20 00:00:00

  • The unmeasured burden: Contribution of depression and psychological stress to patient-reported outcomes in atrial fibrillation.

    abstract：INTRODUCTION:Patient-reported outcomes are routinely assessed in atrial fibrillation (AF) to evaluate efficacy of treatment and as clinical trial outcomes. The relation of depression to such measures has had limited study in AF. METHODS:In a cohort receiving treatment for AF, we assessed depression with the Patient He...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.12.004

    authors： Gisi B,Althouse AD,Mathier AS,Pusateri A,Rollman BL,LaRosa A,Magnani JW

    更新日期：2020-03-01 00:00:00

  • Echocardiographic diagnosis of clinically silent congenital coronary artery anomalies.

    abstract：BACKGROUND:The incidence of congenital coronary anomalies is mainly derived from autopsy series and pre-participation exams in athletes. Limited data exist regarding the spectrum of coronary anomalies that can be detected in asymptomatic patients. We sought to describe echocardiographically detected congenital coronary...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2007.04.063

    authors： Lytrivi ID,Wong AH,Ko HH,Chandra S,Nielsen JC,Srivastava S,Lai WW,Parness IA

    更新日期：2008-06-06 00:00:00

  • Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy.

    abstract：BACKGROUND:Recurrent myocardial ischemia has been recognized as playing an important role in the pathophysiology of hypertrophic cardiomyopathy (HCM) and cardiovascular magnetic resonance (CMR), with or without gadolinium, is a promising method of evaluating fibrosis, edema and hypoperfusion. The aim of this study is t...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2007.06.023

    authors： Melacini P,Corbetti F,Calore C,Pescatore V,Smaniotto G,Pavei A,Bobbo F,Cacciavillani L,Iliceto S

    更新日期：2008-08-29 00:00:00

  • Acute systolic heart failure with normal admission BNP: clinical features and outcomes.

    abstract：INTRODUCTION:The characteristics and outcomes of patients hospitalized with acute systolic heart failure (HF) and normal admission B-type natriuretic peptide (BNP) has not been previously explored. METHODS:Using the ESCAPE trial data, we compared patients with acute HF and left ventricular ejection fraction (LVEF) ≤30...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijcard.2016.12.069

    authors： Omar HR,Guglin M

    更新日期：2017-04-01 00:00:00

  • Maximal spatial ST-vector patterns in patients with acute anteroseptal myocardial infarction.

    abstract：:Seventy patients with acute myocardial infarction were studied by serial vectorcardiography. Eleven out of 70 patients had acute myocardial infarction, which consistently met the vectorcardiographic QRS-loop criteria of anteroseptal myocardial infarction within the 21 days follow-up period. From the first vectorcardio...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)90005-1

    authors： Carson W,Tseng YZ

    更新日期：1994-02-01 00:00:00

  • Atorvastatin attenuates post-implant tissue degeneration of cardiac prosthetic valve bovine pericardial tissue in a subcutaneous animal model.

    abstract：AIMS:The aim of our study was to examine the effects of statin therapy (atorvastatin) on post-implant structural changes of bovine pericardial tissue in a subcutaneous animal model. METHODS AND RESULTS:Sixty male C57BL/6 mice underwent subcutaneous dorsal implantation of bovine pericardial fragments. Animals were rand...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2008.11.174

    authors： Lorusso R,Corradi D,Maestri R,Bosio S,Curulli A,Beghi C,Gerometta P,Russo C,Gelsomino S,Moreo A,De Cicco G,Rosano G,Volterrani M

    更新日期：2010-05-14 00:00:00

  • Idiopathic recurrent sustained parasystolic ventricular tachycardia responsive to verapamil in a 15-year-old patient.

    abstract：:A 15-year-old patient is presented with parasystolic ventricular tachycardia which was responsive to oral verapamil. We emphasize the value of verapamil in the treatment of this uncommon arrhythmia. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(87)90300-7

    authors： Maisuls E,Maor N,Lorber A

    更新日期：1987-04-01 00:00:00

  • Opening of calcium-activated potassium channels improves long-term left-ventricular function after coronary artery occlusion in mice.

    abstract：BACKGROUND:Opening of mitochondrial calcium-activated potassium channels (BKCa) reduces infarct size after myocardial ischemia/reperfusion injury (I/R). It is unknown if targeting BKCa-channels improves cardiac performance in the long-term after I/R. METHODS:Experiments were conducted in compliance with institutional ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.04.084

    authors： Behmenburg F,Hölscher N,Flögel U,Hollmann MW,Heinen A,Huhn R

    更新日期：2017-08-15 00:00:00

  • Is off-pump coronary artery bypass grafting superior to drug-eluting stents for the treatment of coronary artery disease? A meta-analysis of randomized and nonrandomized studies.

    abstract：BACKGROUND:As drug-eluting stent (DES) has almost overcome the disadvantage of frequent restenosis, off-pump coronary artery bypass grafting (OPCAB) has been introduced to avoid complications of cardiopulmonary bypass. However, which approach may promise better outcomes for patients with coronary artery disease remains...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2014.04.182

    authors： Lu D,Nie X,Wan J,He S,Du S,Zhang Z,Wang Z,Wang W

    更新日期：2014-07-01 00:00:00

  • Usefulness of basal B-type natriuretic peptide levels for the diagnosis of diastolic heart failure in young patients: an echocardiographic-catheterization study.

    abstract：:The aim of the present study was to address the diagnostic relevance of B-type natriuretic peptide (BNP) for the diagnosis of diastolic heart failure (DHF) in young patients presenting with chronic, isolated dyspnea. We prospectively included 26 consecutive patients with a left ventricular ejection fraction >50% refer...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2009.03.127

    authors： Arques S,Jaubert MP,Bonello L,Roux E,Armero S,Sbragia P,Nicoud A,Paganelli F

    更新日期：2010-11-05 00:00:00

  • Is 10-second electrocardiogram recording enough for accurately estimating heart rate in atrial fibrillation.

    abstract：BACKGROUND:At present, the estimation of rest heart rate (HR) in atrial fibrillation (AF) is obtained by apical auscultation for 1min or on the surface electrocardiogram (ECG) by multiplying the number of RR intervals on the 10second recording by six. But the reasonability of 10second ECG recording is controversial. M...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.04.139

    authors： Shuai W,Wang XX,Hong K,Peng Q,Li JX,Li P,Chen J,Cheng XS,Su H

    更新日期：2016-07-15 00:00:00

  • Vasculoprotective properties of enhanced external counterpulsation for coronary artery disease: beyond the hemodynamics.

    abstract：:A growing pool of evidence has shown that enhanced external counterpulsation (EECP) is a non-invasive, safe, low-cost, and highly beneficial therapy for patients with coronary artery disease. However, the exact mechanisms of benefit exerted by EECP therapy remain only partially understood. The favorable hemodynamic ef...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2012.04.003

    authors： Yang DY,Wu GF

    更新日期：2013-06-05 00:00:00

  • Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration.

    abstract：BACKGROUND:Abnormal prolongation of QRS duration is a common finding in patients with chronic heart failure, and is associated with an impaired prognosis. The optimum QRS duration for separating chronic heart failure patients with respect to prognosis has not been determined. Whilst resynchronisation of ventricular con...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(02)00270-x

    authors： Kalra PR,Sharma R,Shamim W,Doehner W,Wensel R,Bolger AP,Genth-Zotz S,Cicoira M,Coats AJ,Anker SD

    更新日期：2002-12-01 00:00:00

  • Significance of plasma fibrinogen in coronary arterial disease: marker or causative risk factor for arterial thrombosis?

    abstract：:The relationship between fibrinogen and severity of disease was measured in patients with coronary arterial disease (n = 301) prior to surgical coronary revascularisation. Platelet reactivity (shear-induced haemostasis) was measured from non-anticoagulated blood, in vitro. Coagulation was assessed by the clotting time...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(92)90055-8

    authors： Kovacs IB,Ratnatunga CP,Ridler CD,Görög P,Edmondson SJ,Rees GM

    更新日期：1992-04-01 00:00:00

  • Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan.

    abstract：:The molecular background of the Ca(2+)-sensitizing effect of levosimendan relates to its specific interaction with the Ca(2+)-sensor troponin C molecule in the cardiac myofilaments. Over the years, significant preclinical and clinical evidence has accumulated and revealed a variety of beneficial pleiotropic effects of...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2011.07.022

    authors： Papp Z,Édes I,Fruhwald S,De Hert SG,Salmenperä M,Leppikangas H,Mebazaa A,Landoni G,Grossini E,Caimmi P,Morelli A,Guarracino F,Schwinger RH,Meyer S,Algotsson L,Wikström BG,Jörgensen K,Filippatos G,Parissis JT,Gonzále

    更新日期：2012-08-23 00:00:00

  • Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study.

    abstract：BACKGROUND:The effect of gout on the risk of developing coronary artery disease (CAD) is uncertain. Some studies have found that gout is a risk factor for acute myocardial infarction. This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2017.02.013

    authors： Lin HC,Daimon M,Wang CH,Ho Y,Uang YS,Chiang SJ,Wang LH

    更新日期：2017-04-15 00:00:00

  • Giant P waves and focal atrial tachycardia in a patient with ventricular noncompaction.

    abstract：:A case of ventricular noncompaction with Giant P waves and focal atrial tachycardia is presented. A 36-year-old man was admitted to our hospital because of palpitations and a progressive worsening of heart failure. A 12 lead rest electrocardiogram showed large positive waves followed by smaller negative waves in limb ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.11.149

    authors： Zhou Y,Zhang P,Zhou Q,Guo J,Xu Y,Li X

    更新日期：2008-01-11 00:00:00

  • Predictors of high Killip class after ST segment elevation myocardial infarction in the era of primary reperfusion.

    abstract：BACKGROUND/INTRODUCTION:Outcome after ST segment elevation myocardial infarction (STEMI), has improved but patients with high Killip class still have a poor prognosis, and those ≥II need a closer monitoring in a specialized cardiac care unit. PURPOSE:We aimed to determine the predictors of Killip class in a group of p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.07.038

    authors： Vicent L,Velásquez-Rodríguez J,Valero-Masa MJ,Díez-Delhoyo F,González-Saldívar H,Bruña V,Devesa C,Juárez M,Sousa-Casasnovas I,Fernández-Avilés F,Martínez-Sellés M

    更新日期：2017-12-01 00:00:00

  • The impact of a 21-day ultra-endurance ride on the heart in young, adult and older adult recreational cyclists.

    abstract：BACKGROUND:This study assessed the acute effect of 21 days of challenging exercise on heart structure and function in recreationally active people across a range of age categories. METHODS:15 recreationally active people completed a 21-day fundraising cycling ride (MADRIDE) over a distance of 3515 km. Twenty-four hour...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.03.016

    authors： Wundersitz D,Williamson J,Nadurata V,Nolan K,Lavie C,Kingsley M

    更新日期：2019-07-01 00:00:00

  • Coordinated proteomic signature changes in immune response and complement proteins in acute myocardial infarction: the implication of serum amyloid P-component.

    abstract：BACKGROUND:Patient outcomes after acute myocardial infarction (AMI) are influenced by the combined activation of several distinct interrelated signaling pathways. Specifically acute-phase response proteins can neutralize inflammatory agents, minimize the extent of tissue damage, and participate in tissue repair and reg...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.07.181

    authors： Cubedo J,Padró T,Badimon L

    更新日期：2013-10-15 00:00:00

  • Lack of evidence of association between MTHFR C677T polymorphism and congenital heart disease in a TDT study design.

    abstract：INTRODUCTION:Hyperhomocysteinemia is frequently associated with congenital defects of the heart and neural tube. A common missense mutation in the MTHFR gene (C to T substitution at position 677 changing valine to alanine) produces a variant with reduced enzymatic action, resulting in higher plasma levels of homocystei...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2004.10.049

    authors： Pereira AC,Xavier-Neto J,Mesquita SM,Mota GF,Lopes AA,Krieger JE

    更新日期：2005-10-20 00:00:00

  • Left main stem rupture caused by methicillin resistant Staphylococcus aureus infection of left main stent treated by covered stenting.

    abstract：:Coronary artery infection after angioplasty or stent implantation is a rare and dreaded complication of percutaneous coronary intervention. 80% of the cases are due to Staphylococcus aureus. About half the cases lead to rupture or perforation of the coronary artery while the other half presents as abscesses or aneurys...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2008.12.106

    authors： Wu EB,Chan WW,Yu CM

    更新日期：2010-10-08 00:00:00

  • Congestive heart failure due to aortic incompetence with intestinal infarction due to endarteritis obliterans.

    abstract：:A 27-year-old man with congestive heart failure due to aortic incompetence and subsequent intestinal infarction was found at laparotomy to have extensive necrosis of the bowel due to proliferative endarteritis. Symptoms resolved following treatment with prednisolone and cyclophosphamide, and replacement of the aortic ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90017-j

    authors： Purvis JA,Adgey AA,O'Hara MD

    更新日期：1991-03-01 00:00:00

  • Reduction in Filamin C transcript is associated with arrhythmogenic cardiomyopathy in Ashkenazi Jews.

    abstract：BACKGROUND:Filamin C is a cytoskeletal protein expressed in cardiac cells. Nonsense variations in the filamin C gene (FLNC) were associated with dilated and arrhythmogenic cardiomyopathies. METHODS AND RESULTS:We identified an intronic variation in FLNC gene (c.3791-1G > C) in three unrelated Ashkenazi Jewish families...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.04.005

    authors： Oz S,Yonath H,Visochyk L,Ofek E,Landa N,Reznik-Wolf H,Ortiz-Genga M,Monserrat L,Ben-Gal T,Goitein O,Beinart R,Glikson M,Freimark D,Pras E,Arad M,Nof E

    更新日期：2020-10-15 00:00:00

  • Ventriculo-atrial shunt causing tricuspid endocarditis: its percutaneous removal.

    abstract：:A 21-year-old patient developed tricuspid endocarditis with the distal sections of two redundant ventriculo-atrial shunts remaining in the right atrium. We report their percutaneous removal using a Dotter basket. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(90)90071-c

    authors： Bellamy CM,Roberts DH,Ramsdale DR

    更新日期：1990-08-01 00:00:00

  • Objective measures of the frailty syndrome (hand grip strength and gait speed) and cardiovascular mortality: A systematic review.

    abstract：BACKGROUND:Handgrip strength (HGS) and gait speed (GS) are objective components of the frailty syndrome in the elderly, and are associated with increased all-cause mortality. However, their association with cardiovascular (CVD) mortality is less lucid. The present systematic review aims to summarize the available liter...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.04.068

    authors： Chainani V,Shaharyar S,Dave K,Choksi V,Ravindranathan S,Hanno R,Jamal O,Abdo A,Abi Rafeh N

    更新日期：2016-07-15 00:00:00