Abstract：
:Despite the advances in imaging modalities and surgical techniques, the management of adults with congenital heart disease (ACHD) over the years has remained largely empirical rather than evidence-based. Animal models have been difficult to develop and very costly, while clinical trials are difficult to design and perform in ACHD, leaving gaps in our understanding of the pathophysiology and treatment of congenital heart disease. Disease modelling, both hypothetical and patient-specific, provides an alternative solution to many of these problems. Advances in cardiovascular imaging and diagnostics have led to the easy acquisition of large quantities of structural and functional information, which cannot be handled "intuitively". Computational modelling introduces mathematical rigour in the analysis and utilisation of these data by quantitative simulation and testing of clinically relevant hypotheses through experimentally validated models. Close multidisciplinary collaboration between bioengineers and clinicians is essential for transforming data and images derived from models of disease into clinically useful information.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Giannakoulas G,Dimopoulos K,Xu XYdoi
10.1016/j.ijcard.2008.10.039subject
Has Abstractpub_date
2009-04-03 00:00:00pages
141-4issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(08)01114-5journal_volume
133pub_type
社论abstract：AIMS:Congenital coronary artery fistulas are frequently identified in adult and pediatric populations and they have been associated with various clinical and morphological features. The purpose of this study was to define the clinical and coronary angiographic morphological characteristics of adult patients with congen...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2005.01.047
更新日期：2006-01-26 00:00:00
abstract：BACKGROUND:Aortic pressure waveforms are calculated non-invasively by applying generalized transfer functions (GTF) to tonometric radial pressure waveforms. Input errors mainly during acquisition and calibration of tonometric pressures are "transferred" to aortic pressure calculation. The present study aimed to quantif...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2005.07.014
更新日期：2006-06-07 00:00:00
abstract：BACKGROUND:The focus of the diagnostic process in chest pain patients at the emergency department is to identify both low and high risk patients for an acute coronary syndrome (ACS). The HEART score was designed to facilitate this process. This study is a prospective validation of the HEART score. METHODS:A total of 2...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2013.01.255
更新日期：2013-10-03 00:00:00
abstract：:Several trials have targeted neutral endopeptidase to demonstrate benefits for patients with heart failure. In the PARADIGM-HF trial, a combination of sacubitril and valsartan was superior to enalapril in reducing the risk of death and of hospitalization for heart failure. In this editorial we apply the trial to heart...
journal_title：International journal of cardiology
pub_type： 社论
doi：10.1016/j.ijcard.2016.02.130
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Ischemic coronary artery disease (CAD) is a major cause for morbidity and mortality resulting in a continuously increasing number of diagnostic interventions. We have validated a new hybrid imaging method using minimized radiation dose for rapid non-invasive prediction of invasive coronary angiography (CA) f...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2010.08.023
更新日期：2011-11-17 00:00:00
abstract：BACKGROUND:The rapid adoption of percutaneous transluminal coronary angioplasty (PTCA) in Korea is provoking a widespread concern about possible overuse of this procedure with inappropriate indications. This study aimed to assess the rate of appropriate application of PTCA in Korea and investigate factors affecting thi...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2003.03.028
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Untreated and preclinical heart failure patients with reduced ejection fraction (HFrEF) have an impaired ability to alleviate excess intravascular volume. OBJECTIVES:To investigate 1) the renal response to intravascular volume expansion in euvolemic and optimally treated HFrEF patients and 2) loop diuretic ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.05.041
更新日期：2017-09-15 00:00:00
abstract：:We compared the specificity of exercise electrocardiography in 1880 men and 1818 women with women grouped by menopausal and estrogen replacement status. Specificity for > or = 1 mm horizontal or downsloping ST-segment depression was determined using angiography in 781 patients and using two other nonangiography-based ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(97)02953-7
更新日期：1997-06-27 00:00:00
abstract：BACKGROUND:To quantify the decline in recurrent major cardiovascular events (MCVE) risk in patients with clinically manifest vascular disease between 1996 and 2014 and to assess whether the improvements in recurrent MCVE-risk can be explained by reduced prevalence of risk factors, more medication use and less subclinic...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.07.026
更新日期：2018-01-15 00:00:00
abstract：INTRODUCTION:Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.11.180
更新日期：2015-02-01 00:00:00
abstract：:The mortality and morbidity were assessed during a 2-year follow-up in an acute intervention trial in suspected acute myocardial infarction with metoprolol (a selective beta 1-blocker). On admission to the trial, the 1395 participating patients were randomly allocated to metoprolol or placebo for 3 months. Thereafter,...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-5273(86)90010-0
更新日期：1986-03-01 00:00:00
abstract：:We report a case of pacemaker endocarditis due to Stenotrophomonas maltophilia in a 22-year-old Caucasian man with d-transposition of the great arteries after atrial switch procedure. S.maltophilia isolated from blood cultures was susceptible to trimethoprim-sulfamethoxazole and amikacin, and resistant to ciprofloxaci...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.12.164
更新日期：2010-12-03 00:00:00
abstract：:The effects of 5 and 10 mg of amlodipine and of placebo were compared in 21 patients with stable angina pectoris and multivessel coronary artery disease. The blind comparison was performed by means of bicycle ergometry and stress echocardiography using esophageal stimulation of the left heart atrium. All patients subs...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0167-5273(92)90137-r
更新日期：1992-10-01 00:00:00
abstract：:We hypothesized that, within the normal range of resting heart rate, heart rate and left ventricular ejection fraction would be inversely correlated and heart rate and left ventricular filling would be correlated in patients with dilated cardiomyopathy and not correlated in patients with normal cardiac function. At re...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(99)00139-4
更新日期：1999-12-15 00:00:00
abstract：:This paper aims at examining whether there is an association between the circadian patterns of systolic blood pressure, heart rate and the incidence of ventricular ectopic beats, as well as to confirm that reducing the blood pressure by a diuretic may also reduce the ectopic frequency. Thirty-four ambulatory patients ...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0167-5273(92)90078-h
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunctio...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.07.028
更新日期：2013-09-10 00:00:00
abstract：OBJECTIVE:Show how lunar catecholamine cardiomyopathy alone, exemplified by Neil Armstrong's single space walk, prior to exposure to inhalation of fine particulate matter, can trigger " Neil Armstrong Syndrome" or by Irwin with coronary, possibly hypertensive heart disease, and catecholamine cardiomyopathy. With space ...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2016.10.052
更新日期：2017-03-15 00:00:00
abstract：BACKGROUND:The present study was conducted to investigate the relation between the accumulation of the risk factors of thromboembolism and the levels of hemostatic markers in patients with nonvalvular atrial fibrillation (NVAF). METHODS:Five hundred ninety-one NVAF patients and 129 control subjects were categorized in...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2007.06.020
更新日期：2008-06-06 00:00:00
abstract：OBJECTIVES:Recent data indicate that hypertension is not well controlled in many populations throughout the world. The factors that influence individual response to anti-hypertensive treatment need to be clarified. Pulse wave velocity (PWV), as a marker of arterial stiffness, has been demonstrated to have important rel...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ijcard.2014.10.049
更新日期：2015-01-15 00:00:00
abstract：:Only rarely have serious side effects been reported with the use of intravenous dipyridamole. We describe two cases of severe bradycardia, of which one led to asystole, in patients undergoing dipyridamole-thallium studies. The association between beta blocker therapy and the seven reported cases of asystole with dipyr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(93)90108-s
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:Hypobaric hypoxia (HH) during flight might be more detrimental to pulmonary circulation in Fontan patients compared healthy individuals. This study was designed to clarify whether exercise-induced hypoxia could predict HH during flight in Fontan patients. METHODS AND RESULTS:Percutaneous oxygen saturation (...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.09.069
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Cardiac myxomas (CMs) are a major primary heart tumor which often causes unexpected symptoms or sudden death. Among CMs, biatrial myxomas are even rare. This study was designed to investigate the clinical characteristics and surgical treatment of 5 cases with biatrial myxoma, to summarize the treatment exper...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.11.171
更新日期：2017-02-01 00:00:00
abstract：:We determined whether vaso-vagal syncope during sheath removal after percutaneous coronary intervention leads to a higher incidence of major adverse cardiac events including acute stent thrombosis, in 611 patients who participated in our previous trial assessing the impact of intravenous sedation and local anaesthesia...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.02.059
更新日期：2008-07-04 00:00:00
abstract：:Between July 1974 and May 1979, 19,153 non-randomized patients without prior cardiac surgery and with chest pain were studied angiographically and enrolled in the Coronary Artery Surgery Study (CASS). The primary question addressed by this paper is: for fixed levels of coronary artery disease, are the presence and sev...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(89)90011-9
更新日期：1989-09-01 00:00:00
abstract：:We present a patient with pericardial tamponade due to amyloid heart disease. A 64-yr-old man was admitted to the hospital because of fatigue and the abrupt development of chest pain and dyspnea. Echocardiography showed severe pericardial effusion and total pericardiectomy was necessary. Ten months later laboratory st...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90115-j
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) imposes both direct costs to healthcare systems and indirect costs to society through morbidity, unpaid care costs, premature mortality and lost productivity. The global economic burden of HF is not known. METHODS:We estimated the overall cost of heart failure in 2012, in both direct and ...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2013.12.028
更新日期：2014-02-15 00:00:00
abstract：BACKGROUND:Results from previous studies support the association of lipoprotein(a) [Lp(a)] levels and coronary artery disease risk. In this study, we analyzed the association between baseline Lp(a) levels and future progression of coronary artery calcification (CAC) in apparently healthy Korean adults. METHODS:A total...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.07.219
更新日期：2016-11-01 00:00:00
abstract：:Cardiac pacing from either endocardial or transesophageal sites has proven useful in termination of sustained supraventricular tachycardia in children. In two patients we demonstrated the efficacy of external pacing in the termination of sustained supraventricular tachycardia. The ease and apparent safety of the techn...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(90)90056-b
更新日期：1990-08-01 00:00:00
abstract：:A 13-year-old black male who died suddenly as a result of atresia of the left coronary ostium and left main coronary artery is presented. An association between this anomaly and supravalvar aortic stenosis is observed. The literature is reviewed and 14 similar cases are compared. Presentation of this anomaly is variab...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/0167-5273(89)90284-2
更新日期：1989-03-01 00:00:00
abstract：:Directional coronary atherectomy has been applied to aorto-ostial lesions with higher success and lower complication rates than conventional balloon angioplasty. Aortic injuries have been reported with this technique, most resulting from the tip of the catheter. In this report, an aortic dissection caused by the shaft...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(96)02671-x
更新日期：1996-08-01 00:00:00
