Abstract:
:The effects of 5 and 10 mg of amlodipine and of placebo were compared in 21 patients with stable angina pectoris and multivessel coronary artery disease. The blind comparison was performed by means of bicycle ergometry and stress echocardiography using esophageal stimulation of the left heart atrium. All patients subsequently received placebo, amlodipine 5 mg and 10 mg for 2 weeks. In bicycle ergometry both doses of amlodipine in comparison with placebo significantly lowered the ST segment depression in lead V5 and prolonged the time to onset of angina. The exercise duration was significantly prolonged only after 10 mg of amlodipine. In stress echocardiography 10 mg of amlodipine significantly improved ejection fraction and reduced wall motion score during stimulation and increased peak velocity of relaxation of left ventricular posterior wall at rest and immediately after stimulation. In the patients with left ventricular end-diastolic pressure < or = 20 mmHg, amlodipine reduced the ratio of peak transmitral flow velocity in atrial contraction to that in early diastole (A/E) at rest and shortened deceleration time at rest and immediately after stimulation. Amlodipine in patients with stable angina pectoris significantly improved the exercise tolerance and the function of the left ventricle in a dose-dependent way. Amlodipine was well tolerated.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Meluzín J,Stejfa M,Novák M,Zeman K,Spinarová L,Julínek J,Toman J,Simek Pdoi
10.1016/0167-5273(92)90137-rsubject
Has Abstractpub_date
1992-10-01 00:00:00pages
101-9issue
1eissn
0167-5273issn
1874-1754pii
0167-5273(92)90137-Rjournal_volume
37pub_type
临床试验,杂志文章abstract::In our study we tried to evaluate systolic and diastolic function in patients with chronic heart failure (CHF) by using some echocardiographic parameters and invasively measured pulmonary capillary wedge pressure (PCWP). We studied 19 patients with CHF NYHA II-III at rest, at the end of isometric exercise (handgrip) a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(97)02924-0
更新日期:1997-05-23 00:00:00
abstract::Aberrant origin of the main stem of the left coronary artery from the right sinus of Valsalva caused angina of effort in a 40 year-old patient. Diagnosis was revealed by transoesophageal echocardiography and confirmed by selective coronary angiography. Aorto-coronary bypass was performed in order to prevent the recurr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90050-y
更新日期:1991-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.04.007
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.010
更新日期:2016-09-15 00:00:00
abstract:BACKGROUND:Handgrip strength (HGS) and gait speed (GS) are objective components of the frailty syndrome in the elderly, and are associated with increased all-cause mortality. However, their association with cardiovascular (CVD) mortality is less lucid. The present systematic review aims to summarize the available liter...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.04.068
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND:Increased risk of death in patients with primary hyperparathyroidism (PHPT) is referred to cardiovascular complications induced by hypercalcemia. At the moment the role of bioelectrical risk and of enhanced sympathetic activity, not related to cardiovascular complications, is unknown in PHPT patients. METHO...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.08.072
更新日期:2007-10-01 00:00:00
abstract::We report the case of a 64 year old man with two vessel coronary artery disease and a left main coronary artery to pulmonary artery fistula. He underwent coronary artery bypass grafting, but the coronary artery fistula was not closed. He developed recurrent angina due to coronary steal from the distal left anterior de...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.04.003
更新日期:2009-11-12 00:00:00
abstract:BACKGROUND:The involvement of iron in anthracycline cardiotoxicity is supported by extensive experimental data, and by the preventive efficacy of dexrazoxane, an iron chelator. However, no clinical evidence of anthracycline-induced cardiac iron accumulation is available and the influence of previous iron overload or of...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.09.046
更新日期:2012-02-09 00:00:00
abstract::A 54-year-old woman without organic heart disease presented with presyncopal symptoms during work. A decreased cardiac output was demonstrated by haemodynamic measurements during exercise. Treatment with fludrocortisone and ephedrine was initiated with a good haemodynamic and symptomatic result. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90255-4
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:It is known that coronary heart surgery leads to varying degrees of cardiac autonomic derangement, clinically detectable as depression of heart rate variability (HRV) parameters. Few studies report that also surgical replacement of the aortic valve (SAVR) may lead to HRV abnormalities, while very little is k...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.06.004
更新日期:2015-10-15 00:00:00
abstract::We report three young Chinese male patients who underwent aortic valve replacement for severe aortic regurgitation of subacute onset, complicated by recurrent dehiscence of the aortic valve prosthesis, due to aortitis. One of the three patients underwent aortic valve replacement three times and progression of the pros...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/0167-5273(96)02754-4
更新日期:1996-10-11 00:00:00
abstract::Two patients referred for heart transplantation for dilated cardiomyopathy on chronic tricyclic antidepressant treatment are described. Echocardiographic normalization of left ventricular diameters and function were evidenced after drug withdrawal, suggesting drug-induced toxic myocardial disease. The possibility of f...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)02231-7
更新日期:1995-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.129
更新日期:2010-06-11 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen. It promotes re-endothelialisation of the damaged vessel surface seen after stenting. Stent thrombosis and in-stent restenosis are partly related to endothelial denudation caused by stent implantation. We propose using hydrocarb...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(03)00102-5
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Patients with small ventricular septal defects (VSDs) are thought to have excellent long-term survival, although complications may not be uncommon. METHODS:We identified all patients aged ≥ 16 years with native isolated VSD between January 2000 and September 2013. Clinical outcomes were retrospectively revi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.01.208
更新日期:2016-04-01 00:00:00
abstract::A 72-year-old man with a large mass in the right atrium and the pulmonary embolism by chest computed tomography was diagnosed as the primary cardiac B-cell lymphoma (PCL) with pulmonary tumor embolism and pericardial effusion. Upon completion of initial chemotherapy, the mass was markedly reduced, and the pulmonary em...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.06.054
更新日期:2006-07-28 00:00:00
abstract::Cardiac hypertrophic program is a chronic, complex process, and occurs in response to long-term increases of hemodynamic load related to a variety of pathophysiological conditions. Mitochondria, known as "the cellular power plants", occupy about one-third of cardiomyocyte volume and supply roughly 90% of the adenosine...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.09.082
更新日期:2013-08-20 00:00:00
abstract::We describe a series of five patients who had cardiac tamponade at the time of initial presentation as a result of extracardiac malignancy. Three cases had adenocarcinoma and two had squamous cell carcinoma. The diagnosis of bronchogenic carcinoma was established after appropriate investigations in three cases. One pa...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90063-6
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Inflammation plays a major role in the pathogenesis of coronary artery disease (CAD). METHODS:We hypothesized, that quantifying inflammation by measuring circulating interleukin-6 concentrations help in the diagnosis and/or prediction of functionally relevant CAD. Among consecutive patients with symptoms su...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.10.029
更新日期:2019-01-15 00:00:00
abstract::Implanted defibrillators have become a mainstream therapy for the prevention of sudden cardiac death (SCD) from ventricular tachyarrhythmias in patients with chronic coronary artery disease. A decade of studies has confirmed the superiority of ICDs over antiarrhythmic drug therapy in prolonging the life of patients wi...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2003.10.032
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Meta-analysis of trial data suggests that in primary cardiovascular disease (CVD) prevention bodyweight modifies low-dose aspirin's effects on colorectal cancer (CRC) and major bleeding risk. We sought to investigate whether these effects are seen in patients with or without CVD in routine clinical practice ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.08.001
更新日期:2019-12-15 00:00:00
abstract::Rhythm control of atrial fibrillation (AF) remains challenging, with modest long-term success rates. Atrial fibrosis has been associated with AF, but the clinical utility of assessment of this fibrosis has yet to be fully elucidated. In this paper we review the current state of understanding of the pathophysiology of ...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.06.144
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Periodontitis (PD) and type 2 diabetes (T2D) are characterized by increased mitochondrial oxidative stress production (mtROS), which has been associated with a greater risk of cardiovascular diseases (CVD). Intensive PD treatment (IPT) can significantly improve endothelial function and metabolic control, alt...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2018.05.019
更新日期:2018-11-15 00:00:00
abstract::We have previously reported that serum and/or urinary human heart-type cytoplasmic fatty acid-binding protein (HH-FABPc) can be used as an early indicator of myocardial injury (Clin Biochem 1991; 24: 195-201). To confirm the usefulness of HH-FABPc as an early diagnostic indicator of acute myocardial infarction (AMI), ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90117-y
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Exercise intolerance is a widespread and serious problem in chronic heart failure (CHF) patients. However, the impact of a supervised exercise and rehabilitation program on exercise tolerance and cardiac performance in severe CHF patients has not yet been fully investigated. METHODS:Of 56 consecutive patien...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.021
更新日期:2007-04-04 00:00:00
abstract:BACKGROUND:The relative importance of focal drivers, multiple wavelets, rotors and endocardial-epicardial circuits in the maintenance of persistent AF remains unclear. Our objective was to characterize AF wavefront (WF) dynamics during persistent AF. METHODS:The Ensite 3000 (St Jude Medical) non-contact mapping system...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.085
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Women with cardiac disease and their infants are at a greater risk of mortality and morbidity during pregnancy. Expert groups recommend preconception counseling (PCC) for all women with cardiac disease so they are made aware of these risks. We have run a specialist maternal cardiac clinic since 1996. The aim...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.03.092
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). The role of the NADPH oxidase (NOX) signaling in the setting of DM and the potential benefits of apocynin on diabetic atrial remodeling remain unknown. METHODS:Sixty Japanese rabbits were randomized into 3 groups as follows: ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.132
更新日期:2016-10-15 00:00:00
abstract::When writing a review manuscript, choosing among potentially citable references is an arduous task. Decisions are commonly based on several aspects, ranging from obvious content relevance, passing through impact factor of the journal in which a prospective citable article was written, and reaching to sovereign persona...
journal_title:International journal of cardiology
pub_type: 评论,历史文章,信件
doi:10.1016/j.ijcard.2008.04.053
更新日期:2009-08-14 00:00:00
abstract:BACKGROUND:Inflammation is a major contributor to atherosclerotic vascular disease. Inflammatory parameters such as C-reactive protein (CRP) and Interleukin-6 (IL-6) have been shown to be strong predictors of cardiovascular events. The association between preoperative inflammatory parameters and early graft occlusion a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.09.004
更新日期:2007-08-09 00:00:00