Abstract:
BACKGROUND/OBJECTIVES:Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension. The aims of this study are to assess right ventricular glucose and fatty acid in chronic thromboembolic pulmonary hypertension (CTEPH) patients before and after pulmonary thromboendarterectomy and to examine whether there is a correlation between right ventricular glucose and fatty acid uptake. METHODS:To assess glucose and fatty acid accumulation in the RV, [(18)F] fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) and (123)I-β-methyl iodophenyl pentadecanoic acid (BMIPP) imaging were performed in CTEPH patients before (FDG: n=20, BMIPP: n=13) and after (FDG: n=12, BMIPP: n=8) thromboendarterectomy. RESULTS:Both [(18)F] FDG uptake and (123)I-BMIPP uptake in RV of post-PEA patients obviously decreased after this operation procedure (p<0.01). The right ventricle [(18)F] FDG uptake was also significantly correlated with (123)I-BMIPP uptake (r=0.45, p=0.04). CONCLUSIONS:In this study, we observed that both glucose and fatty acid accumulated in the RV of patients with CTEPH. Although the exact details of the altered energy metabolism in the stressed RV remain unknown, this is the first study to evaluate both glucose and fatty acid uptake before and after thromboendarterectomy in patients with CTEPH, even though the number of the patient is limited.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Sakao S,Daimon M,Voelkel NF,Miyauchi H,Jujo T,Sugiura T,Ishida K,Tanabe N,Kobayashi Y,Tatsumi Kdoi
10.1016/j.ijcard.2016.06.010subject
Has Abstractpub_date
2016-09-15 00:00:00pages
143-9eissn
0167-5273issn
1874-1754pii
S0167-5273(16)31019-1journal_volume
219pub_type
杂志文章abstract::Recently, cardiovascular outcome trials with glucose-lowering drugs used in type 2 diabetes mellitus, namely glucagon-like peptide-1 receptor agonists (GLP-1RA), liraglutide and semaglutide, showed a reduction in cardiovascular events, which had not been observed in trials with other incretin-based drugs, such as lixi...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2017.02.126
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus (T2DM) and hypertension are independently related to increasing risk of subsequent incident heart failure with preserved ejection fraction (HFpEF). This study was designed to evaluate the influences of long-term metformin prescription in these patients. METHODS:Using a propensity sc...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.11.087
更新日期:2020-05-01 00:00:00
abstract::Gossypiboma, a term used to describe a mass within the body composed of a cotton matrix which usually refers to a retained surgical sponge, is a rare complication of cardiac surgery. We report one case revealed by the recurrence of the anginal symptoms after successful myocardial revascularisation surgery. The preoper...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00003-0
更新日期:1999-07-31 00:00:00
abstract:BACKGROUND:Stent fractures after drug-eluting stent (DES) implantation have not been evaluated sufficiently in patients with long coronary artery disease. METHODS:This study comprised of 415 patients, who were enrolled in the Long-DES-II study and had a complete serial angiography both before and after procedure and a...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2008.01.005
更新日期:2009-04-17 00:00:00
abstract::Brain natriuretic peptide (BNP) modulates several biological processes by activating the natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases natriuresis, diuresis and vasodilatation, thus resulting in a decreased cardiac workload. BNP and NT-proBNP, which is the biologically inactiv...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.07.109
更新日期:2016-10-15 00:00:00
abstract:BACKGROUND:Chagas' cardiomyopathy (CC) is a rising etiology for heart failure (HF) that previously was restricted to some countries of Latin America. The chronic CC cases cause now a profound socio-economic impact. However this issue has not been well studied if compared to other causes of HF. The objective of this stu...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.01.262
更新日期:2013-10-03 00:00:00
abstract:BACKGROUND:Our goal was to study associations between childhood socioeconomic position (SEP), adulthood SEP, adulthood risk factors and cardiovascular disease (CVD) mortality, by investigating the critical period and pathway models. METHODS:The prospective GLOBE study in the Netherlands, with baseline data from 1991, ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.01.219
更新日期:2013-10-03 00:00:00
abstract::Time-frequency maps of signal-averaged electrocardiogram based on a short time Fourier transform (STFT) technique analysis was employed to assess the presence of high frequency electrical transients (turbulence) and arrhythmia risk assessment. The optimal configuration set of STFT variables aiming at risk stratificati...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.04.013
更新日期:2010-11-05 00:00:00
abstract:OBJECTIVE:To study the joint prevalence of elevated blood pressure and raised total cholesterol in adult individuals and to estimate the multifactorial cardiovascular risk associated with this clustering. MATERIAL AND METHODS:Data were obtained through pooling of databases from large cross-sectional representative pop...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.08.037
更新日期:2006-06-16 00:00:00
abstract:BACKGROUND:Risk stratification of patients following acute myocardial infarction (AMI), in order to identify patients whose clinical outcomes can be improved through specific medical interventions, is needed. OBJECTIVES:Development and validation of a prognostic tool comprising a variety of non-cardiovascular co-morbi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.09.014
更新日期:2012-01-26 00:00:00
abstract:BACKGROUND:Traditional risk factors for cardiovascular disease (CVD) have been thoroughly investigated. We aimed to investigate the impact of comorbid cardiovascular risk factors and diseases on length of stay (LOS) and mortality in patients presenting with acute coronary syndromes (ACS). METHODS:We examined prevalenc...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.06.188
更新日期:2016-10-01 00:00:00
abstract::Tissue valve dystrophic calcification, resulting in hemodynamic regurgitation and/or stenosis, is the most serious complication when bioprosthetic heart valves are concerned. The objective of this investigation was to define morphologically the sequential development of calcific deposits in pericardial tissue cusps of...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90269-x
更新日期:1986-09-01 00:00:00
abstract::Fistulas between coronary arteries and cardiac cavities or other vascular structures are uncommon findings usually detected early in life. We describe two cases of late transcatheter occlusion of a double coronary artery fistula in adults complaining of incremental dyspnoea. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.069
更新日期:2007-11-30 00:00:00
abstract:BACKGROUND:Patients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac struct...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.03.108
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The platelet chemokine CXCL4 induces monocyte differentiation resulting in a macrophage phenotype called "M4", which co-expresses CD68, MMP7, and S100A8. We hypothesized that M4 macrophages are associated with plaque destabilization. METHODS:Atherosclerotic arteries were obtained from explanted hearts of pa...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.03.151
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The risk of ischemic stroke, systemic thromboembolism, and all-cause death among heart failure patients previously diagnosed with diabetes mellitus is poorly described. We evaluated the risk of these endpoints among heart failure patients without diagnosed atrial fibrillation according to the presence of diab...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.02.004
更新日期:2016-04-15 00:00:00
abstract::Ischemic heart disease is the major cause of death, disability and lost productivity in the developed countries of the world. The evolution of cardiac care units has improved patient survival from myocardial infarctions, but requires a high-tech, very expensive treatment facility. Chest pain centers, located in emerge...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00160-6
更新日期:2000-01-15 00:00:00
abstract::We report a female case of variant form of tako-tsubo cardiomyopathy in which wall motion of the distal segment was preserved. In the current case, left ventriculography showed akinesia of the mid portion and normokinesia of the distal and basal portions of the left ventricular chamber. ST-segment elevation was obviou...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.121
更新日期:2007-07-10 00:00:00
abstract::During acute myocardial infarction and in the reperfused heart, loss of cardiomyocytes is mostly caused by apoptosis and necrosis. As apoptosis was considered as the only form of regulated cell death for many years, initial studies investigating cardiomyocyte cell death mainly focused on direct inhibition of apoptosis...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.03.055
更新日期:2013-05-25 00:00:00
abstract:BACKGROUND:Approximately 40% of patients with heart failure have preserved left ventricular systolic function with latent diastolic dysfunction associated with left ventricular hypertrophy, suggesting that diastolic dysfunction participates in the pathophysiology of heart failure. However, the cause or prerequisite sta...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.07.004
更新日期:2007-05-16 00:00:00
abstract::We reviewed the reports of 27 patients who had an aortic valve replacement after previous coronary artery bypass grafting. The aortic valve disease -- mainly aortic stenosis -- showed a rapid rate of progression. In the time interval between coronary artery bypass grafting and aortic valve replacement of 4.6+/-2.2 yea...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00018-7
更新日期:1998-04-01 00:00:00
abstract::Congestive heart failure due to thyrotoxicosis without preexisting heart disease is rare. Indeed, the very existence of a thyrotoxic heart disease has been much discussed. We describe a 44-year-old woman in whom thyrotoxicosis was found to be the sole cause of congestive heart failure. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90065-4
更新日期:1988-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the association between antidepressant use and incident coronary heart disease (CHD) events in a sample of individuals without known baseline heart disease. PARTICIPANTS AND METHODS:We studied a group of 970 randomly selected community-dwelling adults in the 1995 Nova Sc...
journal_title:International journal of cardiology
pub_type: 信件,随机对照试验
doi:10.1016/j.ijcard.2009.06.036
更新日期:2010-11-05 00:00:00
abstract::We report a patient with Takayasu arteritis (TA) who initially received stent placement (SP) following percutaneous transluminal balloon angioplasty for stenotic lesion of the left subclavian artery and subsequently had recurrent in-stent restenosis three times. Every time restenosis occurred, percutaneous translumina...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2003.04.019
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is associated with an increased risk of cognitive impairment and functional decline, and may contribute to development of dementia. OBJECTIVES:Data from a nationwide large-scale population-based cohort study are lacking. Besides, how best to predict the occurrence of incident dement...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2015.06.170
更新日期:2015-11-15 00:00:00
abstract:BACKGROUND:Perioperative administration of Enoximone has been shown to improve hemodynamics, organ function, and inflammatory response. Aim of the present study was to evaluate the effects of Enoximone after on-pump cardiac surgery. METHODS:A protocol for a multicenter observational study was reviewed and approved by ...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2018.07.071
更新日期:2018-10-15 00:00:00
abstract::We report documenting the "Fatigue" phenomenon in the accessory pathway of a patient with Wolff-Parkinson-White syndrome. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90290-6
更新日期:1985-06-01 00:00:00
abstract::This case report describes a female patient with a cluster of four supraventricular tachycardias during the third trimester of pregnancy. The patient was surgically corrected with a Senning operation at the age of 15. Due to numerous monomorphic atrial tachycardias at the age of 28 an ablation using the noncontact map...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.124
更新日期:2008-01-24 00:00:00
abstract::Right ventricular (RV) infarction or dysfunction is commonly complicated with acute inferior myocardial infarction. In this report, we describe a patient with unstable angina pectoris who showed a temporary isolated RV dysfunction. The patient had total occlusion of proximal right coronary artery, including RV branch,...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.095
更新日期:2008-02-20 00:00:00
abstract::The relationship between transoesophageal Doppler pulmonary venous flow pattern and spontaneous left atrial contrast was studied in 23 patients with isolated severe mitral stenosis (mitral valve area = 0.8 +/- 0.2 cm2). The patients with none or minimal (1+) spontaneous contrast (n = 15, group I) were compared with th...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90307-o
更新日期:1992-09-01 00:00:00