当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease.

Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease.

Abstract：

BACKGROUND:Inflammation plays a major role in the pathogenesis of coronary artery disease (CAD). METHODS:We hypothesized, that quantifying inflammation by measuring circulating interleukin-6 concentrations help in the diagnosis and/or prediction of functionally relevant CAD. Among consecutive patients with symptoms suggestive of CAD, functionally relevant CAD was adjudicated in two domains: first, diagnosis according to myocardial perfusion single photon emission tomography (MPI-SPECT) and coronary angiography; second, cardiovascular death and all-cause death during 2-years follow-up. Adjudication was done blinded to the interleukin-6 concentrations. RESULTS:Among 1553 patients, symptoms were adjudicated to be causally related to CAD in 43% (665/1553). Interleukin-6 concentrations were higher in patients with functionally relevant CAD as compared to those without (1.56 pg/mL versus 1.30 pg/mL, p < 0.001), but overall had only low-to-modest diagnostic accuracy (area under the curve [AUC]: 0.57, 95%CI 0.55-0.61) and were no independent predictor of functionally relevant CAD after multivariable adjustment (p = 0.068). Interleukin-6 concentrations had moderate-to-high accuracy in the prediction of cardiovascular death (AUC 0.75, 95%CI 0.69-0.82) and all-cause death (AUC 0.72, 95%CI 0.66-0.78) at 2-years, and remained a significant predictor after multivariable adjustment (p < 0.001). Compared to patients with interleukin-6 concentrations below the median (1.41 pg/mL), patients with concentrations above the median had a significantly higher cumulative incidence of cardiovascular death (1% vs. 4%, log-rank p < 0.001) and all-cause death (2% vs. 8%, log-rank p < 0.001) at 2 years. CONCLUSION:Interleukin-6 concentrations are strong and independent predictors of cardiovascular death and all-cause death.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Walter J,Tanglay Y,du Fay de Lavallaz J,Strebel I,Boeddinghaus J,Twerenbold R,Doerflinger S,Puelacher C,Nestelberger T,Wussler D,Amrein M,Badertscher P,Todd J,Rentsch K,Fahrni G,Jeger R,Kaiser C,Reichlin T,Mueller C

doi

10.1016/j.ijcard.2018.10.029

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

20-25

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(18)33851-8

journal_volume

275

pub_type

杂志文章

在线工具

Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease.