Abstract:
:We report a case of pacemaker endocarditis due to Stenotrophomonas maltophilia in a 22-year-old Caucasian man with d-transposition of the great arteries after atrial switch procedure. S.maltophilia isolated from blood cultures was susceptible to trimethoprim-sulfamethoxazole and amikacin, and resistant to ciprofloxacin and all tested β-lactam antibiotics. The infected pacemaker system was completely removed by thoracotomy. Simultaneously, a new DDD pacemaker and epicardial electrodes were successfully implanted and selective antibiotic therapy consisting of trimethoprim-sulfamethoxazole (480 mg i.v. q 6 h) and amikacin (250 mg i.v. twice daily) was continued. However, the post-operative course was complicated by septic shock and the patient died on 9th day after surgery. Importantly, S.maltophilia isolated from extracted pacemaker leads was multidrug-resistant including to trimethoprim-sulfamethoxazole, ciprofloxacin, all tested aminoglycosides, and β-lactams, with the exception of ticarcillin-clavulanate. In conclusion, pacemaker endocarditis due to Stenotrophomonas maltophilia is an extremely rare but serious complication of permanent pacing therapy. The susceptibility of S.maltophilia isolates to antimicrobial agents can change during the course of infection. Despite the inherent resistance of S.maltophilia to most β-lactam antibiotics, multidrug-resistant strains may be susceptible in vitro to ticarcillin-clavulanate. Further studies are needed to determine the optimal management of patients with pacemaker endocarditis caused by Stenotrophomonas maltophilia.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Rostoff P,Paradowski A,Gackowski A,Konduracka E,El Massri N,Gajos G,Pfitzner R,Drwila R,Sadowski J,Piwowarska Wdoi
10.1016/j.ijcard.2008.12.164subject
Has Abstractpub_date
2010-12-03 00:00:00pages
e92-5issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(08)01598-2journal_volume
145pub_type
信件abstract:BACKGROUND AND AIMS:Plasma aldosterone has been associated with all-cause and cardiovascular mortality in high-risk cardiovascular populations, including patients with heart failure, myocardial infarction and high-risk coronary artery disease (CAD) patients. In the present study, we evaluated the association of plasma ...
journal_title:International journal of cardiology
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2001-12-01 00:00:00
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pub_type: 信件
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更新日期:2010-11-05 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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更新日期:2010-06-11 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2005-05-25 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.12.042
更新日期:2010-06-11 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-08-15 00:00:00
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更新日期:2019-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
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更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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pub_type: 信件
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更新日期:2009-08-14 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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更新日期:2007-03-20 00:00:00
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更新日期:2017-08-15 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-10-10 00:00:00