Abstract:
BACKGROUND:Results from previous studies support the association of lipoprotein(a) [Lp(a)] levels and coronary artery disease risk. In this study, we analyzed the association between baseline Lp(a) levels and future progression of coronary artery calcification (CAC) in apparently healthy Korean adults. METHODS:A total of 2611 participants (mean age: 41years, 92% mend) who underwent a routine health check-up in 2010 and 2014 were enrolled. Coronary artery calcium score (CACS) were measured by multi-detector computed tomography. Baseline Lp(a) was measured by high-sensitivity immunoturbidimetric assay. Progression of CAC was defined as a change in CACS >0 over four years. RESULTS:Bivariate correlation analyses with baseline Lp(a) and other metabolic parameters revealed age, total cholesterol, HDL-C, LDL-C and CACS to have a significant positive correlation, while body weight, fasting glucose level, blood pressure and triglyceride level were negatively correlated with baseline Lp(a) level. After four years of follow-up, 635 subjects (24.3%) had CAC progression. The participants who had CAC progression were older, composed of more men, more obese, and had higher fasting glucose levels and worse baseline lipid profiles compared to those who did not have CAC progression. The mean serum Lp(a) level was significantly higher in subjects who had CAC progression compared to those who did not (32.5 vs. 28.9mg/dL, p<0.01). When the risk for CAC progression according to baseline Lp(a) was calculated, those with Lp(a) level≥50mg/dL had an odds ratio of 1.333 (95% CI 1.027-1.730) for CAC progression compared to those with Lp(a)<50mg/dL after adjusting for confounding factors. CONCLUSIONS:In this study, the subjects who had higher Lp(a) were at significantly higher risk for CAC progression after four years of follow-up, suggesting the role of high Lp(a) in CAC progression.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Cho JH,Lee DY,Lee ES,Kim J,Park SE,Park CY,Lee WY,Oh KW,Park SW,Rhee EJdoi
10.1016/j.ijcard.2016.07.219subject
Has Abstractpub_date
2016-11-01 00:00:00pages
233-237eissn
0167-5273issn
1874-1754pii
S0167-5273(16)31610-2journal_volume
222pub_type
杂志文章abstract:AIMS:Pressure-controlled Intermittent Coronary Sinus Occlusion (PICSO) intermittently increases the pressure in the cardiac venous outflow tract using a balloon-tipped catheter introduced percutaneously into the coronary sinus. It aims to improve microvascular perfusion in STEMI patients during PCI, thus improving infa...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:BACKGROUND:To investigate alterations in left ventricular (LV) diastolic function using traditional and novel echocardiographic parameters, following radiation therapy (RT) in breast cancer patients in the acute setting. METHODS:40 chemotherapy-naïve women with left-sided breast cancer undergoing RT were prospectively...
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abstract::Streptokinase is an effective thrombolytic agent which, with early restoration of coronary blood flow, has the potential for limiting infarct size. Distinct from thrombolysis, we studied the effects of streptokinase on reperfusion coronary blood flow and infarct size. Open-chest anesthetized canines underwent a 90 min...
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 评论,信件
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doi:10.1016/j.ijcard.2012.09.097
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2015.04.164
更新日期:2015-01-01 00:00:00
abstract::There is a high prevalence of coronary artery disease (CAD) in patients with left bundle branch block (LBBB); however there are many other causes for this electrocardiographic abnormality. Non-invasive assessment of these patients remains difficult, and all commonly used modalities exhibit several drawbacks. This ofte...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/0167-5273(92)90105-c
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Heart rate variability and baroreceptor sensitivity are measures of autonomic control. While progestagen-containing replacement therapy in postmenopausal women adversely affects autonomic balance, the impact of hormonal contraceptives with synthetic progestagens on autonomic activity, neurohormones and C-rea...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.06.052
更新日期:2006-07-28 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2010.11.014
更新日期:2011-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.03.082
更新日期:2009-08-14 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-10-29 00:00:00
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journal_title:International journal of cardiology
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更新日期:2017-03-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
abstract::The in-stent thrombosis is considered as a serious complication of percutaneous coronary intervention. The impaired response to the antiplatelet therapy may play an important role in this crucial problem. Recurrent thrombosis can be explained by genetic background. Because the phenomenon of clopidogrel resistance is a...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.11.048
更新日期:2006-08-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2007-02-14 00:00:00
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pub_type: 杂志文章
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